Ask about this productRelated genes to: NR5A1 Blocking Peptide
- Gene:
- NR5A1 NIH gene
- Name:
- nuclear receptor subfamily 5 group A member 1
- Previous symbol:
- FTZF1
- Synonyms:
- FTZ1, SF-1, ELP, AD4BP, hSF-1, SF1
- Chromosome:
- 9q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-06-07
- Date modifiied:
- 2018-02-14
Related products to: NR5A1 Blocking Peptide
Related articles to: NR5A1 Blocking Peptide
- The ovary contains two major somatic lineages, granulosa cells and interstitial cells, that arise from progenitors within the coelomic epithelium. However, how these two lineages diverge during ovarian development remains unclear. By analyzing joint single-nucleus transcriptomic and chromatin accessibility profiles of murine ovarian cells at the onset of ovary formation, we identified two somatic progenitor populations from the coelomic epithelium distinguished by expression of the nuclear receptors and . Based on their transcriptomic trajectories, the epithelial cells preferentially transitioned toward the granulosa lineage whereas the epithelial cells differentiated into mesenchymal populations. This lineage relationship was supported by lineage tracing experiments that fetal progenitors contribute to ovarian interstitial cells postnatally. To define the molecular features underlying this divergence, we performed differential gene expression and chromatin accessibility analyses and found that epithelial cells, but not cells, were enriched for Notch pathway components and Notch effector motifs. Consistently, lineage tracing of Notch-responsive cells marked interstitial cells in postnatal ovaries, whereas ectopic Notch activation in cells promoted expansion of the interstitial population accompanied by reduced granulosa cells. By integrating motif analysis with accessible chromatin-gene linkage, we also identified downstream targets regulated by Notch effectors in cells, which showed concordant changes upon ectopic Notch activation. These findings demonstrate that somatic cell fate is established early during ovarian development, with active Notch signaling specifying the interstitial lineage and a balanced Notch activity required for proper somatic lineage establishment. - Source: PubMed
Publication date: 2026/04/22
Chen Yu-YingRattan SaniyaLiu ChangXu XinYao Humphrey H-C - The clinical phenotype and pathogenic mechanism of 46,XY disorders of sex development (DSD) are complex, and several pathogenic variants are identified by next-generation sequencing. However, these variants currently require additional interpretation and validation prior to their application in 46,XY DSD diagnosis and clinical guidance. - Source: PubMed
Publication date: 2026/04/29
Li CuiYang BinyuLi XuZhen ShuaiLiu XiaogangLi PingpingChen WeiWang XiaoyanXue Mei - Lung cancer remains a leading cause of cancer-related mortality, largely due to its complex immune microenvironment and molecular heterogeneity. To address gaps in understanding tumor heterogeneity and the role of long non-coding RNA (lncRNA) macromolecules, we conducted an integrative single-cell RNA sequencing (scRNA-seq) analysis of non-small cell lung cancer (NSCLC). Unsupervised clustering identified distinct immune and malignant cell populations. Differential expression analysis identified robust cell-type markers, including novel lncRNA macromolecules, AC005842.1, AC009041.2, and AC007240.1 enriched in specific tumor and immune subsets. Functional enrichment linked these lncRNAs to key cancer pathways, including epithelial-mesenchymal transition (EMT), hypoxia, and immune modulation. Targeted experimental validation using quantitative real-time PCR (qRT-PCR) in NSCLC cell lines confirmed significant upregulation of the identified lncRNAs and supported activation of EMT-associated molecular programs. Pseudotime trajectory modeling uncovered dynamic activation of hallmark programs, notably TNFA-NFκB and IL2-STAT5 signaling, suggesting progressive immune suppression and metabolic reprogramming during tumor evolution. We further identified novel transcription factor-pathway associations, including NR5A1-OXPHOS (oxidative phosphorylation) and FOXA2-mTORC1, pointing to uncharacterized axes of macromolecular regulation. To ensure reproducibility and accessibility, we developed lncScape, a modular, open-source Shiny application for integrative lncRNA analysis in single-cell datasets. lncScape implements a pipeline for clustering, lncRNA detection, pseudotime modeling, and GSVA-based pathway enrichment. It also introduces two novel scoring strategies the lncRNA Dynamics Score (LDS) and TF-lncRNA Dynamics (TLD) to prioritize dynamic regulatory lncRNAs based on expression patterns and transcription factor associations. Our findings expand understanding of lncRNA macromolecules in lung cancer and provide a practical platform for lncRNA-centric research. - Source: PubMed
Publication date: 2026/04/15
Haider AliDin Rahman UdHabib BushraLi Chunhua - The differences in egg production performance among hens are closely linked to the efficiency of follicle selection, which is characterized by granulosa cell differentiation and progesterone production. In this study, by integrating ATAC-seq and mRNA-seq analyses on granulosa cells from pre-hierarchical (Pre-GCs) and hierarchical (Post-GCs) follicles, we set out to identify key regulatory factors involved in chicken follicle selection. - Source: PubMed
Publication date: 2026/04/17
Li DandanQi ChaoSun YiKang LiWei QingqingJiang Yunliang - NR5A1 encodes steroidogenic factor 1, a master regulator of adrenal and gonadal development. Pathogenic NR5A1 variants are among the most common genetic findings in 46,XY differences of sex development (DSD), yet the broad phenotypic spectrum remains incompletely defined. - Source: PubMed
Publication date: 2026/05/06
Dallago Renata TBatista Rafael LochDomenice SorahiaNunes-Nogueira Vania Dos SantosMendonca Berenice Bilharinho