Ask about this productRelated genes to: MNAT1 Blocking Peptide
- Gene:
- MNAT1 NIH gene
- Name:
- MNAT1 component of CDK activating kinase
- Previous symbol:
- -
- Synonyms:
- MAT1, RNF66
- Chromosome:
- 14q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-09
- Date modifiied:
- 2019-01-25
Related products to: MNAT1 Blocking Peptide
Related articles to: MNAT1 Blocking Peptide
- Neoadjuvant chemoradiation (nCRT) is a standard treatment for rectal carcinoma that reduces tumor size and local recurrence while improving the rate of sphincter preservation. However, many patients remain insensitive to nCRT, with some exhibiting tumor progression. To date, there is still a lack of clinically available prognostic models to differentiate the sensitivity of patients with rectal carcinoma to nCRT. This study aimed to develop a genetic predictive model that predicts the effectiveness of nCRT in patients with rectal carcinoma, offering guidance for future treatments and studies on the underlying mechanisms. - Source: PubMed
Publication date: 2026/03/21
Gao ZhanhuaQiu MinghanYang ZhenFang XinyueYin GuoxingZhang QiaonanLiu JinpuLiu RuxueWang YayunLiu YuyaZhang MengZhang HaiyangZheng XiangqianWang HuiHao JieGao Ming - Decades of artificial selection have left distinct genomic signatures in Pekin duck. Here, we used whole-genome resequencing data from six Pekin duck populations, including two conservation populations and four breeding populations, to explore the genomic footprints left by decades of artificial selection in Pekin ducks. Through allele frequency analyses, we identified specific selective regions among the breeding populations. Compared with the conservation populations, the strongest selection signals in Maple Leaf ducks were found in genomic regions encompassing FAM184B and LAP3, with two missense mutations in FAM184B showing marked allele frequency differences between Maple Leaf and conservation populations, while in Cherry Valley ducks, the top signals were located within or near XRCC3, MNAT1, and SLC34A2. In comparisons between the Nankou Pekin duck breeding populations and the conservation population, NUDT6 and INPP4A were identified as the candidate genes under selection in PK4 and PK3, respectively. Analysis of the shared selective regions revealed 214 candidate genes, which were mainly enriched in pathways related to lipid metabolism and organ development. These results suggest that different breeding programs have imposed distinct selection pressures on the Pekin duck genome. Overall, this study provides valuable insights for the conservation and genetic improvement of Pekin ducks. - Source: PubMed
Publication date: 2026/01/18
Zhang XinyeZhao XiurongYang FangxiWang GangRen XufangChen AnqiJiang XiaoyuLi XianyaoQu Lujiang - Oral squamous cell carcinoma, with high global incidence and mortality, requires improved early intervention strategies. Ubiquitination - a critical post-translational modification - has been strongly implicated in tumorigenesis, with particularly significant roles in T-cell regulation. We developed a T Cell-Related ubiquitination risk model that enhances prognostic prediction and immunotherapy response assessment, offering a framework for personalized OSCC manageme. - Source: PubMed
Publication date: 2025/10/29
Gao HanLiu LehuaQian WeixiangWu YanfeiWang JiayaoYang WeipingShi Yinfang - Understanding the role of transcript isoforms is essential for elucidating disease mechanisms. TDP-43 regulates RNA splicing, and its dysfunction in neurons is a hallmark of some neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). While an association between TDP-43-dependent cryptic exons and disease pathogenesis has been suggested, an approach to investigate how cryptic exons disrupt transcript isoforms has yet to be established. In this study, we developed IsoRefiner, a novel method for identifying full-length transcript structures using long-read RNA-seq. Leveraging this method, we performed long-read RNA-seq, guided by prior short-read RNA-seq, to comprehensively determine the full-length structures of aberrant transcripts due to TDP-43 dysregulation in human iPSC-derived motor neurons. We identified a novel TDP-43-dependent cryptic exon in the MNAT1 gene, along with its full-length transcript structure. Furthermore, we confirmed the presence of the MNAT1 cryptic exon in patients with ALS and FTD. Our findings deepen understanding of TDP-43 proteinopathy and advance splicing research. - Source: PubMed
Publication date: 2025/07/16
Tanaka YoshihisaSunamura NaohiroKajitani ReiIkeguchi MarieKunimoto Ryo - Laryngeal squamous cell carcinoma (LSCC), the predominant histological subtype of laryngeal cancer with a poor diagnosis, requires further exploration of its molecular mechanisms and potential therapeutic targets. - Source: PubMed
Publication date: 2025/07/11
An RanYang FanTeng YujianGuo YanZhao RuiCao JingLiu YaohuiWang YueLiu PengyanLiu MingTian Linli