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GRAMD2 Blocking Peptide product offer - Gentaur Molecular Products

GRAMD2 Blocking Peptide

Price:

216.14 €

Known as:: GRAMD2 Blocking Peptide
Catalog number:: 33r-5276
Product Quantity:: USD
Category:: -
Supplier:: Fitzgerald industries international
Gene target:: GRAMD2 Blocking Peptide

Ask about this product

Related genes to: GRAMD2 Blocking Peptide

Gene:: GRAMD2A ^{NIH gene}
Name:: GRAM domain containing 2A
Previous symbol:: GRAMD2
Synonyms:: -
Chromosome:: 15q23
Locus Type:: gene with protein product
Date approved:: 2005-11-02
Date modifiied:: 2019-02-21

Related products to: GRAMD2 Blocking Peptide

α - Calcitonin Gene Related Peptide, α - CGRP, rat&_945;2&_946;1 Integrin Ligand Peptide&_946;_catenin peptide(Ala92)-Peptide 6 98% C93H155N31O26 CAS:(Arg)9 Peptide (Arg8)-Vasopressin Biotin peptide This is (Arg8)-Vasopressin Biotin peptide. For research use only.(Asn5)-Delta-Sleep Inducing Peptide (Asn5)-Delta-Sleep Inducing Peptide (rabbit), (Asn5)-DSIP (rabbit) 98% C35H49N11O14 CAS: 80064-67-1(Asn5)_Delta_Sleep Inducing Peptide Salt _ Binding _ Synonym (Asn5)_Delta_Sleep Inducing Peptide (rabbit), (Asn5)_DSIP (rabbit) SumFormula C35H49N11O14(Asn5)_Delta_Sleep Inducing Peptide Salt _ Binding _ Synonym (Asn5)_Delta_Sleep Inducing Peptide (rabbit), (Asn5)_DSIP (rabbit) SumFormula C35H49N11O14(Biotin Conjugates) Dopamine D2 Receptor Immunogen: peptide Host: Rabbit(Biotin Conjugates) Glucose Transporter 1 Immunogen: peptide Host: Rabbit(Biotin Conjugates) PDE3A(goat) Immunogen: peptide Host: Rabbit(Biotin Conjugates) PDE7A(Goat) Immunogen: peptide (23mer) Host: Rabbit(Biotin Conjugates) Phospho-calcium channel 2A subunit Immunogen: peptide Host: Rabbit(Biotin Conjugates) Phospho-cyclic 5'-nucleotidase Immunogen: peptide Host: Rabbit

Related articles to: GRAMD2 Blocking Peptide

GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells".
GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS. - Source: PubMed
Publication date: 2018/04/18
Nunes PaulaDemaurex Nicolas
GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells.
Endoplasmic reticulum (ER) membrane contact sites (MCSs) are crucial regulatory hubs in cells, playing roles in signaling, organelle dynamics, and ion and lipid homeostasis. Previous work demonstrated that the highly conserved yeast Ltc/Lam sterol transporters localize and function at ER MCSs. Our analysis of the human family members, GRAMD1a and GRAMD2a, demonstrates that they are ER-PM MCS proteins, which mark separate regions of the plasma membrane (PM) and perform distinct functions in vivo. GRAMD2a, but not GRAMD1a, co-localizes with the E-Syt2/3 tethers at ER-PM contacts in a PIP lipid-dependent manner and pre-marks the subset of PI(4,5)P2-enriched ER-PM MCSs utilized for STIM1 recruitment. Data from an analysis of cells lacking GRAMD2a suggest that it is an organizer of ER-PM MCSs with pleiotropic functions including calcium homeostasis. Thus, our data demonstrate the existence of multiple ER-PM domains in human cells that are functionally specialized by GRAM-domain containing proteins. - Source: PubMed
Publication date: 2018/02/22
Besprozvannaya MarinaDickson EamonnLi HaoGinburg Kenneth SBers Donald MAuwerx JohanNunnari Jodi