Ask about this productRelated genes to: NCKAP1L Blocking Peptide
- Gene:
- NCKAP1L NIH gene
- Name:
- NCK associated protein 1 like
- Previous symbol:
- HEM1
- Synonyms:
- -
- Chromosome:
- 12q13.13-q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-27
- Date modifiied:
- 2018-02-13
Related products to: NCKAP1L Blocking Peptide
Related articles to: NCKAP1L Blocking Peptide
- Status epilepticus (SE) is a severe type of epileptic seizure and induces molecular and cellular changes in the brain tissues which contribute to neuron injury. Here we used RNA sequencing to determine changes in hippocampal gene expression in pilocarpine-induced SE mice at 3-hour (SE-3h) and 24-hour (SE-24h) time points, a crucial stage of SE-induced brain acute damage. A total of 366 differentially expressed genes (DEGs) were identified from the SE-3h hippocampus and 570 DEGs from the SE-24h hippocampus, and most of them were up-regulated upon SE induction. Bioinformatical analyses showed that, compared to SE-3h up-regulated genes with poor scores in functional and pathway enrichment, the SE-24h up-regulated genes were predominantly enriched in inflammatory and immune response, positive regulation of response to external stimuli and inflammatory response (GO function), and Microglia pathogen phagocytosis pathway and Tyrobp causal network in microglia (WikiPathway). Specifically, a subset of DEGs such as Tyrobp, C1qc, Itgb2, Ncf2, and Nckap1l involved in the two pathways are present in the inflammatory and immune cascades. Therefore, this study delineates early altered transcriptional profiles in the hippocampus after SE, and highlights up-regulation of a subset of genes might be involved in the activation of microglia-mediated inflammatory and immune responses linked to the early pathogenesis of SE-induced brain injury. - Source: PubMed
Publication date: 2026/03/20
Tang Hui-LingMin YuLong Yue-Sheng - Schizophrenia (SCZ) is a significant and widespread mental illness, where metabolism and inflammation-related genes (MIRGs) are crucial to understanding its underlying biology. This study aimed to identify peripheral biomarkers linked to metabolism and inflammation, validate these through the creation of a diagnostic model, investigate their connections with miRNA and transcription factors (TFs), and find potential drugs for targeting. - Source: PubMed
Publication date: 2026/03/04
Chen YanfangZhang MinQiao LingLu FengJi Shaoping - Lung adenocarcinoma (LUAD) exhibits high genetic heterogeneity and an immunosuppressive tumor microenvironment (TME), often characterized by reduced immune cell infiltration. Tumor-intrinsic regulators of cell cycle and genomic stability, such as MAD2L1, may also influence immune evasion, but their mechanistic role in LUAD remains unclear. - Source: PubMed
Publication date: 2026/01/14
Saini ChainseeVats PrernaBaweja BhavikaNema Rajeev - - Source: PubMed
Publication date: 2025/11/04
Pan WeiyuCui JunliTu SuQian BinLiu XiaoxiaZhu Xingping - Landiolol is a beta-blocker used in the treatment of Sepsis. However, how this drug influences key genes and pathways involved in disease remains unknown. This study aimed to explore potential biomarkers involved in the mechanism of Landiolol's action in sepsis. - Source: PubMed
Publication date: 2025/09/27
Pan WeiyuCui JunliTu SuQian BinLiu XiaoxiaZhu Xingping