Ask about this productRelated genes to: BTN1A1 Blocking Peptide
- Gene:
- BTN1A1 NIH gene
- Name:
- butyrophilin subfamily 1 member A1
- Previous symbol:
- BTN
- Synonyms:
- BT, BTN1
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-07-11
- Date modifiied:
- 2016-10-05
Related products to: BTN1A1 Blocking Peptide
Related articles to: BTN1A1 Blocking Peptide
- Temporomandibular disorders (TMD) show substantial clinical and genetic overlap with anxiety, yet it remains unclear whether TMD risk reflects shared anxiety-related liability or distinct anxiety-independent genetic mechanisms. Disentangling these components is essential for understanding TMD heterogeneity beyond symptom-based classifications. - Source: PubMed
Publication date: 2026/03/09
Cao YuYang XinSvensson PeterChung Wen Raymond WongHan Sng Timothy JieIslam IntekhabHan WeiFeng XingmeiHou BozhiLi YuehuaZheng Lei - Milk fat globule membrane (MFGM) proteins, naturally present in mammary secretions, possess unique structural and functional properties that make them promising ingredients for infant formula. Therefore, this study systematically reviews MFGM protein isolation/extraction methodologies, characterization techniques, functional properties, and food applications. Key findings indicate that combining nanofiltration and HPLC with conventional techniques (e.g., centrifugation, drying) enhances MFGM protein recovery. However, the mechanistic impacts of pH and temperature on extraction efficiency, as well as the synergistic effects of combined techniques, require further investigation. MFGM proteins (e.g., BTN, BTN1A1, MUC1, XOR) exhibit significant effects on immune function, metabolic regulation, neuroprotection, nutritional improvement, and antioxidant activity. Future research should address the low efficiency of MFGM protein extraction/separation and the challenge of balancing cost and precision in characterization methods. This article provides specific guidelines for the development and application of MFGM proteins. - Source: PubMed
Publication date: 2025/08/31
Xie MengtingYuan WenyingTian ZhuhuiTan LiangZhou HuiYang QiaoZhou LeiShan WuLuo JieFan Xiankang - There are no effective drugs for the treatment of low back pain (LBP), intervertebral disk degeneration (IVDD), or sciatica. We aimed to identify potential therapeutic targets through druggable genome-wide Mendelian randomization (MR) analysis. - Source: PubMed
Publication date: 2025/11/04
Sun AochuanLi ZhuangzhuangDu YikeLiu HaoZhan QiuzhongLiu Zhengtang - : This study characterized the endogenous peptide profile of human milk from a Chinese multicenter cohort ( = 200 mothers) using the Orbitrap Fusion Lumos LC-MS/MS. : Samples were collected across different lactation stages (2 and 6 months postpartum) and seven geographic regions (Beijing, Chengdu, Guangzhou, Jinhua, Lanzhou, Weihai, and Zhengzhou). : In total, 6960 peptides derived from 621 proteins were identified. Peptides from the polymeric immunoglobulin receptor (PIGR) were more abundant in the 2nd month than the 6th month, providing a high antimicrobial activity and immune functions for the infants. Moreover, region-specific variations were observed, with milk from Lanzhou exhibiting significantly higher levels of β-casein (CASB) and butyrophilin subfamily 1 member A1 (BTN1A1) peptides compared to other cities. : Furthermore, maternal dietary intake of oils and total fat correlated positively with the intensity of specific antimicrobial peptides, including CASB_199-216, CASB_200-226, and CASB_201-226. Infant growth parameters were inversely correlated with several antimicrobial peptides, although CASB_200-225 demonstrated positive associations. These findings offer novel insights into the dynamics of endogenous peptides in human milk and may guide breastfeeding recommendations and infant formula design. - Source: PubMed
Publication date: 2025/09/30
Chen BaorongLi KaifengWang XiaodanZhang WenyuanHan SunZhang YumengWang YunnaPang XiaoyangXie QinggangLu JingJiang ShilongZhang ShuwenLv Jiaping - TARDBP mediates milk fat secretion in mice by binding to UG-rich sequences in the 3' untranslated region (UTR) of and mRNA and enhancing their mRNA stability. However, its role in bovine milk lipid metabolism remains unclear. To investigate this, we generated knockout (KO) MAC-T cells using CRISPR/Cas9 technology, quantified triacylglycerol (TAG) levels in both cells and culture supernatant, and examined the impact of on mRNA levels in MAC-T cells through transcriptome sequencing. We found that deletion of reduced TAG content in both MAC-T cells and the supernatant, as well as decreased mRNA levels of , , , , and . However, the expression of and was unaffected in bovine MAC-T cells. Sequence analysis further revealed TG-rich sequences within bovine and but not in , , , or and . These findings suggest that may regulate bovine lipid metabolism through a mechanism distinct from that described in mice. This study provides new insights into the molecular role of in bovine milk fat metabolism and establishes a foundation for understanding its contribution to dairy cattle breeding and milk quality improvement. - Source: PubMed
Publication date: 2025/09/05
Zhang YaranZhang QinglanGao YapingXiao YaoWang JinpengYang ChunhongJu ZhihuaWei XiaochaoWang XiugeJiang QiangHuang Jinming