Ask about this productRelated genes to: SH3GL1 Blocking Peptide
- Gene:
- SH3GL1 NIH gene
- Name:
- SH3 domain containing GRB2 like 1, endophilin A2
- Previous symbol:
- -
- Synonyms:
- SH3P8, SH3D2B, CNSA1, EEN, MGC111371
- Chromosome:
- 19p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-26
- Date modifiied:
- 2016-05-18
Related products to: SH3GL1 Blocking Peptide
Related articles to: SH3GL1 Blocking Peptide
- The cuproptosis-related gene (CRG) is identified as a pivotal regulator in breast cancer (BRCA) progression and immune regulation in this study. Through gene expression profiling and meta-analysis of public datasets, was found to be overexpressed in BRCA tumor tissues and correlated with poor prognosis. Single-cell RNA sequencing pinpointed 's expression in epithelial cells and its critical interactions with immune cells, particularly T cells and monocytes. Functional experiments confirmed 's role in promoting immune cell migration and modulating drug sensitivity. Moreover, high expression was linked to reduced immunotherapy response, as revealed by TIDE scoring, suggesting its contribution to the immune microenvironment complexity in high-risk BRCA groups. These results emphasize 's dual role as a prognostic biomarker and a target for therapeutic intervention in BRCA, providing new insights into personalized cancer treatment approaches. - Source: PubMed
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Sheng JindongLuan JingZhao YujieXing YiwenCao WenfengLiu ChunyanLiu RuoyanSun LuLiu Wenxin - Endophilin A, a family of Bin-Amphoterisin-Rvs (BAR) domain-conserved proteins, is found in several tissues and is associated with disease pathogenesis. In patients with breast cancer, endophilin A expression pertains to boosted tumour cell endocytosis, migration, and invadopodia formation, potentially linked to a poor prognosis. - Source: PubMed
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