MGC27016 Blocking Peptide
- Known as:
- MGC27016 Blocking Peptide
- Catalog number:
- 33r-5233
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- MGC27016 Blocking Peptide
Related genes to: MGC27016 Blocking Peptide
- Gene:
- RBM46 NIH gene
- Name:
- RNA binding motif protein 46
- Previous symbol:
- -
- Synonyms:
- MGC27016, CT68
- Chromosome:
- 4q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-24
- Date modifiied:
- 2019-03-19
Related products to: MGC27016 Blocking Peptide
Related articles to: MGC27016 Blocking Peptide
- MEIOC and its two partners, RBM46 and YTHDC2, function as posttranscriptional regulators to promote mitotic-to-meiotic transition in mammalian germ cells. However, the molecular mechanism underlying target mRNA selection and degradation by MEIOC complex is largely unknown. Here, we demonstrate that exogenously expressed RBM46/MEIOC/YTHDC2 binds to and 3'UTR and targets these transcripts for degradation in cultured somatic cells. YTHDC2 stabilizes MEIOC through inhibiting its ubiquitination, and the coiled-coil domain of MEIOC mediates its association with YTHDC2 and RBM46. The target mRNA is required for the interaction of RBM46 with YTHDC2. Moreover, MEIOC recruits XRN2 in the cytoplasm as the likely ribonuclease. We propose that MEIOC is a critical component that recruits RNA binding proteins for target mRNA selection and XRN2 for RNA degradation, and regulates the complex activity by modulating its mRNA and protein stability. - Source: PubMed
Publication date: 2026/06/03
Liang RuixinChen QiziLi JiaweiLiu HanMa YanqiuHan ShenglinLi YunxinGao JingyuYe LanZhou Jian - Do variants in YTH N6-methyladenosine RNA binding protein C2 (YTHDC2) cause male infertility in humans, and what is the underlying pathogenic mechanism? - Source: PubMed
Publication date: 2026/06/05
Zhi AoranLi MingZubair MuhammadAbbas MusavirShah WasimMansoor AbuRahim FazalAli ImtiazRaza YousafMurtaza GhulamAhmad NisarAbideen ZainJiang HanweiShi BaoluZhang HuanShi Qinghua - RNA binding protein RBM46, as an integral component of MEIOC-YTHDC2 complex, governs the RNA binding specificity in posttranscriptional regulation of male meiotic initiation. RBM46 is also indispensable for embryonic oocyte development in mice. However, the precise phenotypic consequences and underlying regulatory mechanisms of RBM46 in female germ cells remain largely uncharacterized. Here, we demonstrate that RBM46 deficiency leads to derepression of CCNA2, meiotic arrest at leptotene stage and widespread germ cell apoptosis in embryonic ovaries. Transcriptomic profiling of RBM46-deficient ovaries at embryonic day 16.5 revealed significant upregulation of Stra8 and Lin28a, alongside downregulation of multiple meiotic genes. In HEK293T cells, ectopic co-expression of RBM46, MEIOC and YTHDC2 promoted degradation of reporter mRNAs bearing either Lin28a or Mga 3'UTR. Notably, Deletion of the RBM46-binding motif "AAUCAU" within Lin28a 3'UTR reduced this repressive effect. Collectively, these findings establish an essential role of RBM46 for meiotic initiation in female germ cells and identify Lin28a and Mga transcripts as direct targets subject to RBM46-mediated decay. - Source: PubMed
Publication date: 2026/05/28
Li JiaweiShen JunMa YanqiuZhou Jian - Bladder cancer is a prevalent malignancy, with high recurrence rates for non-muscle invasive cases and significant progression risks. Traditional diagnostic methods, such as cystoscopy and urine cytology, are limited by their invasiveness and low sensitivity for detecting low-grade tumors, respectively. Advances in non-invasive diagnostics focus on biomarkers such as cfDNA and DNA methylation, offering promising tools for early detection. - Source: PubMed
Publication date: 2026/01/06
Mahdipour ShadiModarressi Mohammad HosseinNoruzinia Mehrdad - Histone lysine-specific demethylase 4A (KDM4A) plays a critical role in the embryonic development of mammals such as mouse and goat, however its function in zebrafish () embryogenesis remains poorly understood, due to the existence of two paralogs ( and ) in zebrafish. The current study revealed that embryos exhibited dramatically increased mortality during gastrulation. RT-qPCR showed that RNA-binding motif protein 46 () was downregulated after knockout. CUT&Tag-qPCR revealed that knockout significantly decreased H3K4me3, while increasing H3K9me3 and H3K36me3 at promoter. embryos displayed elevated reactive oxygen species (ROS) and reduced adenosine triphosphate (ATP). And mRNA injection alleviated ROS accumulation and increased ATP level, thereby rescuing the lethal phenotype in embryos. Our findings demonstrate that knockout disturbs zebrafish embryogenesis by suppressing mRNA expression. - Source: PubMed
Publication date: 2026/03/09
Jiang HuiCai XinqingDeng RuiWang JiaminSong HongkuanChai WeiranHan BingsheZhang Junfang