Ask about this productRelated genes to: SLC35F3 Blocking Peptide
- Gene:
- SLC35F3 NIH gene
- Name:
- solute carrier family 35 member F3
- Previous symbol:
- -
- Synonyms:
- FLJ37712
- Chromosome:
- 1q42.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-25
- Date modifiied:
- 2016-10-05
Related products to: SLC35F3 Blocking Peptide
Related articles to: SLC35F3 Blocking Peptide
- Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. - Source: PubMed
Publication date: 2026/01/20
Díaz-Muñoz CristianBozzarelli IsottaLopera-Maya Esteban AlexanderBelbasis LazarosLo Faro ValeriaCamargo Tavares LeticiaHeredia-Fernández FranciscoDi Lorenzo BiagioSinha TrishlaEsteban Blanco CristinaFavé Marie-JulieAwadalla PhilipWalters Robin GBonfiglio FerdinandoZhernakova AlexandraSanna SerenaD'Amato Mauro - Solute carriers (SLCs) mediate cell- and organelle-specific import and export of nutrients and metabolites required for every biochemical process that occurs in a cell. Functional studies have ascribed activities to many human genes annotated as SLCs, but more than 100 SLCs remain orphans. Here, we applied a set of computational tools to characterize the orphan carriers SLC35F4 and SLC35F5. Phylogenetic analysis grouped SLC35F4 sister to SLC35F3, a suspected thiamine transporter, in a clade with SLC35F5, and distinct from an SLC35F6/2/1 clade. Transcriptome datasets revealed a restricted function for SLC35F4 in the cerebellum, in contrast to the more widespread distribution of SLC35F5. Gene ontology identified the Golgi apparatus as the likely residence of both transporters. Conceptual docking of 71 candidate substrates predicted high affinities of SLC35F4 (10-40 nM) and SLC35F5 (0.1-0.4 nM) for flavin adenine dinucleotide (FAD), straddling that of the known FAD transporter SLC25A32 (2-4 nM), while returning much lower affinities (by 30-fold or more) for all other tested substrates. Docking to SLC35F3 returned low affinity for both FAD and thiamine as candidate substrates. Thus, SLC35F4 and SLC35F5 but not closely related SLC35F3 likely import FAD into the Golgi apparatus, where the cofactor serves as the oxidant for disulfide-bond formation during tissue-specific, post-translational modification of secretory proteins. These findings provide strong direction for the definitive experiments yet needed to confirm the carriers' subcellular localization, transport activities, and contributions to protein maturation and trafficking. - Source: PubMed
Publication date: 2026/01/04
Niu ZheyunJiang DongmingHardy Daniel M - Carrier-mediated uptake of choline is rate-limiting for acetylcholine biosynthesis and various other biological processes. To date, 16 solute carrier (SLC) proteins have been identified that may facilitate choline permeation across the outer cell membrane. However, their biochemical functions have not yet been experimentally compared. We overexpressed 16 SLC proteins with known choline-transporting capacity and compared their choline transport kinetics. Additionally, we evaluated their capacity to transport choline analogues as well as metabolites involved in its biosynthesis and degradation or modulators of cholinergic neurotransmission to gain insight into the biological functions of the SLCs. Furthermore, we investigated whether the transporters could be distinguished by their sensitivity to inhibition by hemicholinium-3 and other substances. Of the 16 SLCs tested, seven (SLC5A7, SLC35F2, SLC35F3, SLC35F4, SLC25F5, SLC35G4, and SLC44A5) exhibited K values for choline transport in the range of 12 to 50 µM, closely aligning with physiological plasma choline concentrations. Among them, SLC5A7 displayed over tenfold higher intrinsic clearance than any of the others. SLC22A1-3 were confirmed as choline transporters, albeit with low affinity. Hemicholinium-3 most strongly inhibited SLC5A7 and also significantly inhibited SLC35F2-5 and SLC35G4. Choline transport by these six transporters was inhibited by about 50 % at 100 µM decynium-22 and verapamil.. In humans, multiple SLCs may contribute to cellular choline uptake, depending on physiologic conditions and their yet incompletely characterized expression patterns. The present data may also enhance our understanding of inherited and environmental modulation of these transporters with possible consequence, for instance, on motor and cognitive functions. - Source: PubMed
Publication date: 2025/09/17
Redeker Kyra-Elisa MariaBrockmöller Jürgen - Molecular research for genetic variants underlying body weight (BW) provides crucial information for this important selected trait when developing productive poultry breeds, lines and crosses. We searched for molecular markers-single nucleotide polymorphisms (SNPs)-and candidate genes associated with this trait in 240 F resource population Japanese quails (). This population was produced by crossing two breeds with contrasting growth phenotypes, i.e., Japanese (with lower growth) and Texas White (with higher growth). The birds were genotyped using the genotyping-by-sequencing method followed by a genome-wide association study (GWAS). Using 74,387 SNPs, GWAS resulted in 142 significant SNPs and 42 candidate genes associated with BW at the age of 1, 14, 28, 35, 42, 49 and 56 days. Hereby, 25 SNPs simultaneously associated with BW at more than one age were established that colocalized with nine prioritized candidate genes (PCGs), including , , , , , , , , and . Twelve PCGs were identified in the regions of two or more significant SNPs, including , , , , , , , , , , , and . These SNPs and PCGs can serve as molecular genetic markers for the genomic selection of quails with desirable BW phenotypes to enhance growth rates and meat productivity. - Source: PubMed
Publication date: 2025/08/25
Volkova Natalia ARomanov Michael NGerman Nadezhda YuLarionova Polina VVetokh Anastasia NVolkova Ludmila ASermyagin Alexander AShakhin Alexey VGriffin Darren KSölkner JohannMcEwan JohnBrauning RudigerZinovieva Natalia A - Racing without protective shoes is common in the Swedish harness racing industry, as it can enhance horses' performance on the track. Trainers typically decide whether a horse will race barefoot based on practical experience rather than objective measures. However, this practice can sometimes lead to excessive hoof wear, posing potential welfare concerns for racing horses. Gene expression differences may help reveal the underlying genetic mechanisms associated with different phenotypic traits. To explore an objective measure for assessing which horses are best suited for barefoot racing, we conducted a polyA-selected RNA-seq experiment on tissue from the growth zone at the coronary band of the hoof. This experiment compared tissues from Standardbred trotters capable of repeatedly racing barefoot without injury (n = 11) to those that could not (n = 7). By combining stringent phenotyping with racing records and trainer interviews, we aimed to elucidate the biological factors related to hoof strength in barefoot racing, focusing on differential abundant genes. - Source: PubMed
Publication date: 2025/08/18
Schwochow DoreenAlameddine AsmaaSpörndly-Nees EllinorMontigny MathildeNaboulsi RakanJansson AnnaNiazi AdnanLindgren Gabriella