Ask about this productRelated genes to: TIPARP Blocking Peptide
- Gene:
- TIPARP NIH gene
- Name:
- TCDD inducible poly(ADP-ribose) polymerase
- Previous symbol:
- -
- Synonyms:
- DKFZP434J214, DKFZp686N0351, DDF1, PARP7, PARP-7, PARP-1, pART14, RM1
- Chromosome:
- 3q25.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-02
- Date modifiied:
- 2016-04-04
Related products to: TIPARP Blocking Peptide
Related articles to: TIPARP Blocking Peptide
- There are few studies on the genomics of heat stress response and the molecular mechanisms of thermoregulation. In this experimental model, Sprague-Dawley rats were subjected to temperatures of 22 ± 1 °C (control group; CT) and 42 °C for varying durations (30, 60, and 120 min, H30, H60, and H120, respectively). Significantly high rectal body temperatures were recorded post-heat stress across all treatment groups. Adrenal corticosterone levels increased significantly, especially in H120 group. Heat stress predictive accuracies of adrenal corticosterone at H60 and H120 were higher with relatively high sensitivity and AUC greater than 0.85. RNA-sequencing of adrenal gland tissue from CT vs. H30, CT vs. H60, and CT vs. H120 identified 4, 8 and 8 known; and 72, 305 and 160 de novo differentially expressed lncRNA (DElncRNAs), respectively. A total of 61, 208, and 124 genes were found to interact with DElncRNAs in the three comparisons, of which 1, 24, and 20 were differentially expressed transcripts (DETs), respectively. Among these known DElncRNAs, Gng 2-202, MAFK-203, Rab32-201, AABR07048992.1-201 were enriched in all three comparisons. Functional enrichment and interaction network analysis of DETs interacting with DElncRNAs indicated their enrichment in pathways related to inflammation-metabolism nexus determined by DETs like Jun, Map3k5, Cyp1b1, Tiparp, Ezh2, and Cbx4. This study will supplement our understanding of the transcriptome level response mechanism of rat adrenal tissue under heat stress and provide theoretical reference for the study of mammalian body response to heat stress stimulation. - Source: PubMed
Publication date: 2026/05/16
Gu JingyiSammad AbdulGuo RenyunKang ShuaiMuniz Maria Malane MagalhãesXu YaxiSheng XihuiDou Jinhuan - BackgroundAxillary lymph node metastasis (ALNM) serves as a critical prognostic determinant in breast cancer, yet the molecular drivers governing lymphatic dissemination remain poorly characterized. Integrating single-cell transcriptomic profiling with Mendelian-randomization (MR)-based genetic prioritization may help reveal cell type-specific mechanisms underlying metastatic progression.MethodsWe analyzed the GSE195861 single-cell RNA sequencing dataset encompassing six invasive ductal carcinoma (IDC) samples and paired ALNM specimens. t-distributed Stochastic Neighbor Embedding-based clustering and SingleR annotation delineated cellular heterogeneity, while differential expression analysis identified metastasis-associated genes in epithelial compartments. MR analysis employing five robust methods (inverse variance-weighted, weighted median, MR-Egger, simple/weighted mode) integrated genome-wide association study data (GCST90018799) to establish causal gene-breast cancer associations. CellChat reconstructed ligand-receptor networks across nine annotated cell types.ResultsUnsupervised clustering resolved 27 cell clusters into nine lineages, revealing ALNM-specific expansion of monocytes, pre-B cells, and CD34+ hematopoietic stem cells (HSCs). Epithelial cells exhibited 2421 differentially expressed genes (DEGs) between IDC and ALNM, including 12 genes whose genetically predicted expression showed significant associations with breast cancer risk in MR analysis (P < 0.05). CD53 (odds ratio (OR) = 1.110, 95% confidence interval (CI) = 1.019-1.209, P = 0.017) and TCDD-inducible poly-ADP-ribose polymerase (TIPARP) (OR = 1.153, 95% CI = 1.032-1.288, P = 0.012) were prioritized as candidate genes, as their genetically predicted expression was associated with increased breast cancer risk in weighted median MR. Cell-cell communication analysis implicated macrophage-derived midkine-nucleolin signaling and B-cell-orchestrated macrophage migration inhibitory factor-(CD74 + CXCR4) axis in metastatic crosstalk. Functional enrichment linked DEGs to extracellular matrix remodeling and MAPK/PI3K-Akt activation.ConclusionThis multi-omics integration prioritizes CD53 and TIPARP as ALNM-associated candidate genes with genetically supported associations with breast cancer risk, with macrophage-epithelial and B-cell-HSC interactions serving as potential therapeutic targets. Our findings provide a roadmap for developing metastasis-interceptive strategies through precision targeting of the ALNM-associated tumor microenvironment. - Source: PubMed
Publication date: 2026/05/12
Qu LimengLi JinyangDing ShirongLong QianYi Wenjun - Bisphenol A (BPA) is an endocrine-disrupting chemical, and long-term low-level exposure is closely associated with ovarian cancer (OC). However, the underlying molecular mechanisms remain unclear. Utilizing the Comparative Toxicogenomics Database (CTD) and the Gene Expression Profiling Interactive Analysis (GEPIA) database, combined with LASSO Cox regression, we constructed a BPA exposure-associated OC risk prognosis model composed of , , , , and . Functional analysis indicated that the risk model and its constituent genes are associated with humoral immune activation and cellular immunosuppression. Furthermore, the activation of neuroactive ligand-receptor interaction signaling appears to be a common molecular mechanism through which these risk genes contribute to OC. Molecular docking, molecular dynamics simulations, and cellular experiments confirmed a stable binding interaction between BPA and the CDKN1B protein. These findings provide scientific data for a deeper understanding of the molecular mechanisms linking BPA to OC, aiding risk prediction and personalized prevention for exposed individuals. - Source: PubMed
Publication date: 2026/04/15
Geng HaiyanZhu JianjunZhang WentaoLiu Ming - Are bioactive human-equivalent doses (HEDs) of perfluorooctane sulfonate (PFOS), derived from long-term low-level exposure of human granulosa cells comparable to HEDs inferred from follicular fluid PFOS concentrations in women undergoing ART and in occupationally exposed women? - Source: PubMed
Publication date: 2026/04/07
Tomanic TamaraSamardzija Nenadov DraganaRadovic Pletikosic SavaStanic BojanaObradovic DarijaLazovic SasaAndric Nebojsa - Ischemic stroke leads to severe cerebral ischemia/reperfusion (I/R) injury, resulting in neuronal death and neurological deficits. The N-methyladenosine (mA) methyltransferase METTL16 has emerged as a key regulator of RNA metabolism, but its specific role and mechanism in ischemic stroke remain unclear. - Source: PubMed
Publication date: 2026/04/12
Xiang MeilingHan JiemiYe ZaiChen BimengWang Hongbo