Ask about this productRelated genes to: STX4 Blocking Peptide
- Gene:
- STX4 NIH gene
- Name:
- syntaxin 4
- Previous symbol:
- STX4A
- Synonyms:
- p35-2
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-23
- Date modifiied:
- 2014-11-18
Related products to: STX4 Blocking Peptide
Related articles to: STX4 Blocking Peptide
- Bovine tuberculosis (bTB), caused by (), remains an ongoing global issue for human and animal health. The Bacille Calmette Guerin (BCG) vaccine offers immunity against bTB, however, the mechanisms underlying the heterogenous protective response, including variations across species and age groups requires further investigation. In this study, we focused on dendritic cells (DCs), which are crucial for adaptive immune stimulation following BCG vaccination. By capturing afferent lymph DCs (ALDCs) migrating from the skin, we investigated shifts in DC profiles and potential subset-specific functions in response to BCG vaccination. Single-cell RNA sequencing (scRNA-seq) was performed on samples from calves (n=3) before and after BCG vaccination, capturing the transcriptome of 20,761 individual cells expressing on average 3,036 genes, which were clustered into ALDCs, monocytes, T-cells, B-cells and NK cells. The ALDC subsets were further identified as cDC1 and cDC2. In homeostasis, ALDCs expressing potential subset-specific genes for cDC1, including ENSBTAG00000056208, , , , , and cDC2; , , , , and were identified. Following BCG vaccination, while both DC subsets exhibited gene expression signatures indicative of antigen-presenting function, migration, and DC maturation, cDC1 showed upregulation of genes consistent with metabolic alterations and lymphocyte recruitment, whereas cDC2 upregulated genes consistent with inflammatory responses. Overall, this study comprehensively describes the transcriptomic landscape of bovine ALDC subsets, providing evidence for the importance of subset-specific genes to BCG vaccination responses, while advancing knowledge on how ALDCs contribute to protective immunity against bTB. - Source: PubMed
Publication date: 2026/04/07
Sukmak RachrapeeMathie Heather ATaylor Richard SSun JianxuanShih BarbaraBell Charlotte RGray MarkMacqueen Daniel JHope Jayne C - Type 1 diabetes (T1D) is characterized by progressive loss of pancreatic b-cell function, which is accelerated by cytokine-induced senescence and the accompanying senescence-associated secretory phenotype (SASP). We investigated whether Syntaxin 4 (STX4), a t-SNARE protein previously recognized for its cytoprotective properties, can mitigate b-cell senescence under diabetogenic stress. - Source: PubMed
Publication date: 2026/03/09
Ahn MiwonOh EunjinVarghese Sneha SMcCown Erika MBhattacharya SupriyoDabrowska KatarzynaLovell Brooke LHansen NathanielPirrotte PatrickThurmond Debbie CDhawan Sangeeta - Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk, but the underlying cell type-specific mechanisms remain unclear. - Source: PubMed
Lindbohm Joni VStražar MartinLee Hang-MaoAshenberg OrrMars NinaSipilä Pyry NRipatti SamuliGraham DanKivimäki MikaXavier Ramnik J - Psoriasis (PsO) demonstrates frequent co-occurrence with metabolic syndrome (MetS). Nevertheless, the shared genetic architecture underlying both pathological conditions remains incompletely characterized. This investigation sought to examine genetic correlations between PsO and multiple MetS-associated traits, and to identify shared genetic risk loci and genes contributing to their coexistence. - Source: PubMed
Publication date: 2026/03/14
Jiang XinZhou PingZhang QiWang WanChunWang Dan - The ATP-binding cassette subfamily C member 1 (ABCC1) is a key efflux pump that contributes to multidrug resistance in cancer by exporting chemotherapeutic agents and xenobiotics. Although ABCC1 is clinically important, the phosphorylation-dependent regulatory mechanisms governing its activity remain poorly understood, representing a major knowledge gap. To address this gap, we performed a large-scale integrative analysis of publicly available phosphoproteomic datasets curated from over 3800 PubMed-indexed studies. From 688 high-confidence datasets, we mapped Class I phosphosites on ABCC1 and focused on two predominant sites, S919 and S930, located within the cytoplasmic linker domain. Using phosphosite co-occurrence and co-regulation strategies, we identified phosphorylation events that consistently co-regulate with these key ABCC1 sites across diverse experimental conditions. Through multilevel statistical filtering (Fisher's exact test, < 0.05), recurrence analysis, and experimental context diversity, we defined a high-confidence co-regulatory network comprising 1266 phosphosites across diverse proteins. Mechanistically, this network reveals coordinated phosphorylation of ABCC1 with its known interacting partners, including PTGES3, FASN, and STX4, as well as functionally associated drug transport proteins such as ABCC4, SLC16A1, and SLC20A2. Functional enrichment analysis further linked the ABCC1-centred phospho-network to carcinogenesis, cell-cycle regulation, and drug resistance pathways, highlighting its systems-level role in cancer biology. From a translational perspective, our findings identify phosphosites within the ABCC1 linker domain as actionable regulatory nodes that may be exploited to modulate transporter function, offering potential strategies to overcome chemoresistance. - Source: PubMed
Publication date: 2026/02/16
Nandakumar RevathyMahin AlthafGopalakrishnan Athira PerunellySubair SuhailKrishnan DeepakRaju Rajesh