TMEM16K Blocking Peptide
- Known as:
- TMEM16K Blocking Peptide
- Catalog number:
- 33r-5070
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- TMEM16K Blocking Peptide
Related genes to: TMEM16K Blocking Peptide
- Gene:
- ANO10 NIH gene
- Name:
- anoctamin 10
- Previous symbol:
- TMEM16K
- Synonyms:
- FLJ10375, MGC47890, SCAR10
- Chromosome:
- 3p22.1-p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-21
- Date modifiied:
- 2018-02-13
Related products to: TMEM16K Blocking Peptide
Related articles to: TMEM16K Blocking Peptide
- Membrane channels are central to bladder function, yet current understanding is shaped disproportionately by a few well-studied families such as TRPA1 and TRPV1. To provide a more balanced view, this review analyzed emerging human transcriptomic datasets to identify the channels most highly expressed in the urinary bladder and examined how they remodel in bladder outlet obstruction and denervation. Sixty-seven channels were prominently expressed at the mRNA level in GTEx bladder tissue, with correlation analyses and protein expression data assigning many to smooth muscle, urothelial, endothelial, or neuronal compartments. Several abundant channels remain largely unstudied in urological contexts, including , , and . Disease-associated remodeling revealed shared and model-specific patterns. Outlet obstruction produced marked upregulation of L-type Ca channel auxiliary subunits and robust changes in CLIC-family channels, whereas denervation induced broader channel downregulation not explained by nerve loss alone. Three channels, , and , were concordantly altered in both conditions, suggesting coordinated changes within interstitial cell networks and mechanotransductive pathways. These findings highlight a diverse and incompletely explored bladder "channel-ome." Expanding research beyond traditional targets may uncover new mechanisms underlying storage and voiding dysfunction and provide opportunities for therapeutic innovation in lower urinary tract disease. - Source: PubMed
Publication date: 2026/04/07
Swärd KarlAndersson Karl-ErikUvelius Bengt - Hereditary cerebellar ataxia (HCA) and hereditary spastic paraplegia (HSP) are rare neurologic disorders that often represent opposite ends of a shared clinical spectrum. Spastic ataxia, defined by the co-occurrence of cerebellar syndrome and overt spasticity, remains comparatively underexplored and is associated with relatively few genetic causes. The aim of this study was to characterize the clinical and genetic features of spastic ataxia in a large HCA cohort and compare them with those of nonspastic HCA. - Source: PubMed
Publication date: 2025/12/04
Damásio JoanaSantos MarianaCosta SaraMoura JoãoSardoeira AnaLemos CarolinaOliveira JorgeBarros JoséSequeiros Jorge - In diploid organisms, deleterious recessive alleles represent a significant component of genetic mutations and often result in lethal effects when in a homozygous state. Large yellow croaker (Larimichthys crocea), a critical marine aquaculture species in China, has shown signs of inbreeding depression due to its limited natural distribution along the coasts of Fujian, Guangdong, and Zhejiang provinces, combined with intensive artificial propagation practices. Identifying loci with deleterious recessive homozygous genotypes is therefore crucial for sustainable industry development. In this study, 1844 large yellow croaker across three consecutive generations were analyzed, resulting in the preliminary identification of 131 loci with missing recessive homozygous genotypes. After excluding false positives through parentage analysis, large-scale validation was conducted using genotype data from 4663 individuals from the MinDong population and 830 individuals from the Daqu population. Ultimately, 22 loci with complete absence of homozygous recessive genotypes were identified across 7337 individuals. The average minor allele frequency (MAF) of these loci was 0.16. Except for LG17_2296176 and LG17_4414232, which exhibited moderate linkage disequilibrium, the remaining 20 loci were largely independent with no observed linkage disequilibrium. Annotation of the 22 loci identified 12 associated genes, including vegfa, sntg2, tcf7, kif2a, lage3, ano10, mpdu1, and others. These genes are involved in key biological processes such as signal transduction regulation, cytoskeletal organization, neural function, and glycan synthesis. To further verify the reliability of the loci with missing recessive homozygous genotypes, heterozygous parental fish carrying 6 randomly selected loci were paired to establish independent families. None of the offspring exhibited recessive homozygous genotypes at these loci, supporting the accuracy of the prior identification. By analyzing genotype data from large yellow croaker populations, this study identifies key loci with missing recessive homozygous genotypes. These findings may offer guidance for selective breeding strategies aimed at minimizing lethal mutations, thereby enhancing population fitness and supporting the sustainable development of the aquaculture industry. - Source: PubMed
Publication date: 2025/06/26
Jiang ZhouZhao JiLi NingWang JiayingPu FeiChi HongshuXu PengZhou Tao - Hereditary spastic paraplegias (HSP) are rare disorders sharing common features of leg spasticity with gait impairment. Simple and complex forms are recognized; over 50% of cases remain unsolved genetically. Little is known about the genetics of HSP among Indigenous Peoples. - Source: PubMed
Publication date: 2025/05/05
Assaedi EkhlasAshtiani SetarehEstiar Mehrdad AGan-Or ZivMcKenzie Erica DShetty AakashRouleau GuySuchowersky Oksana - ANO10-related ataxia is characterized by cerebellar and pyramidal signs, with prominent oculomotor abnormalities, including saccadic abnormalities, strabismus, and ptosis. While nystagmus is frequently observed, the specific subtype of horizontal pendular nystagmus has not been emphasized. This report describes two siblings with early-onset spastic-ataxia with horizontal pendular nystagmus, ultimately diagnosed with SCAR10. This report details the ocular abnormalities spectrum of ANO10-related ataxia by highlighting horizontal pendular nystagmus as a significant clinical feature in early-onset presentations. We also restate the importance of neurological examination, including detailed assessment of ocular movements, for accurate diagnosis and management of hereditary ataxias. - Source: PubMed
Publication date: 2025/03/25
Silva Thiago Yoshinaga TonholoBraga Vinícius LopesProcaci Victor RebeloGouvêa Luane AbdallaFreitas Leonardo FurtadoVillela Darine Christina MaiaMigliavacca Michele PatriciaCeroni José Ricardo MaglioccoSilva André Macedo SerafimOliveira João BoscoSobreira Cláudia Ferreira da RosaBarsottini Orlando Graziani PovoasPedroso José Luiz