Ask about this productRelated genes to: ADCY6 Blocking Peptide
- Gene:
- ADCY6 NIH gene
- Name:
- adenylate cyclase 6
- Previous symbol:
- -
- Synonyms:
- AC6
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-22
- Date modifiied:
- 2019-03-22
Related products to: ADCY6 Blocking Peptide
Related articles to: ADCY6 Blocking Peptide
- Neutralizing sclerostin antibodies (Scl-Ab) mitigate bone loss and promote bone formation to address fracture risk in postmenopausal osteoporosis. Clinically, this treatment is administered monthly for women at high risk of fragility fractures, who are often years into menopause. Preclinical studies have demonstrated that dampening of bone formation occurs with continuous dosing at supraphysiological doses. Osteoporotic bone loss occurs rapidly during early menopause, followed by longer-term changes in bone mineralization and osteocyte activity. Whether earlier administration of lower-exposure Scl-Ab can mitigate bone loss and osteocyte-mediated mineralization is unknown. The objective of this study was to evaluate the effects of early intermittent low-dose Scl-Ab on: (1) osteoclastogenesis and bone resorption, (2) perilacunar remodelling, (3) secondary mineralization, and (4) osteocyte mechanosensitivity. Female retired breeder Wistar rats underwent bilateral ovariectomy and received monthly low-dose Scl-Ab injections (2 mg/kg/month) from 3 to 14 weeks post-OVX, while a control group remained untreated. Early intermittent low-dose Scl-Ab treatment increased bone formation and reduced osteoclastogenesis and catabolic gene expression ((Sost, Ctsk, Mmp9) compared to untreated rats. Treatment also decreased the percentage of empty lacunae and the number of MMP14+ osteocytes, accompanied by lower perilacunar mineral density and smaller lacunar size, indicating improved osteocyte survival and reduced perilacunar remodelling. Conversely, expression of osteocyte-mediated mineralization genes (DMP1, PHEX, OPN, ALP) and mechanotransduction-related genes (Vcl, integrins α5, αV, β1, CX43, Axin2, IFT88, Adcy6, Pkd1, Cav1) were reduced. Together, these findings suggest that early intermittent low-dose Scl-Ab therapy promotes surface bone formation while attenuating osteocyte-mediated mineralization after initial bone loss. - Source: PubMed
Publication date: 2026/04/07
Naqvi Syeda MasoomaAli WahaajAllison HollieO'Sullivan Laura MHoldsworth GillPanadero-Perez Juan AlbertoSchiavi-Tritz JessicaMcNamara Laoise M - Giant pandas subsist almost exclusively on bamboo, a low-nutrient, high-fiber plant. However, the molecular mechanisms underlying their dietary adaptation remain unclear. Recent evidence suggests that dietary plant-derived microRNAs (miRNAs) may influence gene regulation across species boundaries. This study aims to investigate the presence and functional significance of bamboo-derived miRNAs in giant pandas, and to explore their potential regulatory roles through gene expression modulation. - Source: PubMed
Publication date: 2025/11/19
Yan ZhengXu QinHe XinYao YingLiu DingzhenWang Hairui - Fish reproduction requires suitable salinity and temperature, as well as sufficient energy. This study investigated temperature and salinity effects on ovarian development of and energy metabolism differences between reproduction and growth. Two salinities (4‱ and 30‱) and temperatures (18 ± 1 °C and 30 ± 1 °C) formed four treatments: SWNT (30‱, 30 ± 1 °C), SWLT (30‱, 18 ± 1 °C), FWLT (4‱, 18 ± 1 °C), and FWNT (4‱, 30 ± 1 °C). GSI and sex hormones (FSH, LH, E2, and 17α,20β-DHP) were measured. Transcriptome analysis explored how temperature and salinity regulate ovarian development in , while integrated transcriptomic and targeted energy metabolomic analyses revealed energy metabolism differences between ovary and muscle during this process. The results showed that low salinity (4‱) and low temperature (18 ± 1 °C) synergistically promoted ovarian development in the FWLT group, as indicated by a significant increase in GSI and elevated levels of key sex hormones (FSH, LH, E2, and 17α,20β-DHP). Transcriptome analysis showed that low temperature activated pathways involved in steroidogenesis, oocyte maturation, and meiosis, and genes such as , , , , and were significantly upregulated. Salinity changes mainly affected amino acid metabolism, cholesterol metabolism, and the insulin signaling pathway. Genes such as and may regulate ovarian development by regulating hormone synthesis and energy metabolism. Comprehensive transcriptome and metabolome analyses show that glycolysis is downregulated and oxidative phosphorylation is upregulated in the ovary, suggesting that ovarian oogenesis tends to be energized by aerobic metabolism. The TCA cycle may be used more for providing biosynthetic precursors and facilitating the transport of substrates between the mitochondrion and the cytoplasm rather than just as a source of ATP. Muscle tissue relies primarily on glycolysis for rapid energy production and may redistribute energy to the gonads, prioritizing the energy needs of the ovaries and contributing to the dynamic balance between reproduction and growth. This study provides insights into the molecular mechanisms of how environmental factors regulate fish reproduction, providing a theoretical basis and potential molecular targets for the regulation of reproduction and optimization of aquaculture environments. - Source: PubMed
Publication date: 2025/08/27
Peng YangtaoYan LuluZhao ChaoZhang BoZhang BoQiu Lihua - The molecular mechanism underlying abnormal follicular atresia remains to be elucidated. Research conducted to date has indicated that ovarian granulosa cell (GC) apoptosis is a significant contributor to follicular atresia. Abnormalities in follicular atresia can result in decreased reproductive efficiency in pigs. It is evident that comparative studies focusing on healthy, early atresia and progressively atresia follicles, particularly from the perspective of follicular atresia induced by ovarian GC apoptosis, have not yet been reported. Specifically, the use of RNA-seq technology to systematically analyse differentially expressed genes and associated signaling pathways in GCs at different stages of atresia remains unexplored. The research was divided into three distinct groups: control, early atresia, and progressively atresia. Key genes and signaling pathways were elucidated through RNA-seq. A Venn diagram revealed 86 overlapping genes that were upregulated during early atresia and downregulated during progressively atresia. Additionally, another 47 overlapping genes were found to be downregulated during early atresia and upregulated during progressively atresia. These 133 overlapping genes were significantly enriched in multiple KEGG pathways. Additionally, in conjunction with the key gene-related network diagram, 6 signaling pathways related to ovarian GC apoptosis were further screened out. These pathways include ovarian steroidogenesis, progesterone-mediated oocyte maturation, gonadotropin-releasing hormone signaling pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway, and chemokine signaling pathway. Altogether, 12 key genes were identified: SCARB1, IGF1, PRKACA, ADCY6, LDLR, PLD1, CXCL10, IRF7, ISG15, RNase L, OAS2, and STAT1. Six of these genes were randomly selected for qRT-PCR verification, and their expression levels were found to be consistent with the sequencing results. Consequently, the identification of key regulatory factors involved in the apoptotic process provides a theoretical foundation for investigating the mechanisms underlying abnormal follicular atresia in pigs. - Source: PubMed
Publication date: 2025/04/17
Jiang RongSu JingjingXu LinjieYang LilianSui Shiyan - Gestation length (GL) is a critical indicator of reproductive performance in sows and is closely associated with other reproductive traits, such as total number born (TNB) and number born alive (NBA). Despite its importance, the genetic mechanisms underlying GL and its impact on reproductive traits remain poorly understood. In this study, we investigated the relationship between GL and reproductive traits using 7013 farrowing records and conducted an imputed whole-genome sequence-based genome-wide association study (GWAS) for GL in first-parity sows, involving 3005 French Large White sows. Our findings revealed that the heritability of GL ranged from 0.22 to 0.26. Both excessively short and long GLs were associated with negative impacts on TNB, NBA, and other reproductive traits. A total of 64 SNPs exceeded the significance threshold, leading to the identification of two novel quantitative trait loci (QTLs) on chromosome 5 (QTL-1: 15.29-15.39 Mb and QTL-2: 12.86-12.94 Mb) and three promising candidate genes: , , and . Gene ontology and KEGG pathway enrichment analyses revealed that these candidate genes are enriched in key biological processes, including ovarian steroidogenesis, the GnRH signaling pathway, and the regulation of cAMP biosynthesis, all of which are crucial for gestation and pregnancy maintenance. These findings improve our understanding of the genetic architecture of GL in sows and offer valuable genetic markers for enhancing reproductive efficiency in breeding programs. - Source: PubMed
Publication date: 2025/02/06
Duan DongdongZhou ShenpingWang ZhenyuQiao ChuanminHan JinyiLi MengyuZhou HaoLi XinjianXin Wenshui