Ask about this productRelated genes to: Anxa6 Blocking Peptide
- Gene:
- ANXA6 NIH gene
- Name:
- annexin A6
- Previous symbol:
- ANX6
- Synonyms:
- -
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1990-02-01
- Date modifiied:
- 2014-11-19
Related products to: Anxa6 Blocking Peptide
Related articles to: Anxa6 Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/22
Ouyang SiXiong KaixinChen PeijieLiu XiufengLi AnzhouLi JiangWang Yao - Triple-negative breast cancer (TNBC) tumors are typically heterogeneous, predominantly epithelial tissues with discrete patches of mesenchymal-like TNBC cells that differ in their invasiveness, proliferation potential and response to treatment. However, the impact of mesenchymal-like and epithelial TNBC cells on the persistence of chemotherapy-resistant disease remains poorly understood. Mesenchymal-like and epithelial TNBC cell types were detected by multiplex fluorescent immunohistochemistry using antibodies against vimentin, Ki67, and Annexin A6 (AnxA6). Chemotherapy drug-resistant mesenchymal-like and epithelial TNBC cell populations were established by pulse exposure and stepwise dose escalation and validated by 3D cultures and unbiased antibody arrays. Analysis of the response of TNBC tumors treated with six common chemotherapy regimens resulted in 36% complete response and 64% partial response with residual tumor sizes ranging from 0.5 to 37.0 mm. Treatment of TNBC cells with chemotherapy agents led to distinct resistance signatures including downregulation of survivin and upregulation of M-CSF and CXCL8/IL-8 in the model mesenchymal-like TNBC cells, and upregulation of CCL2/MCP-1, CTSS and DKK-1 in model epithelial TNBC cells. The inhibitory phosphorylation of GSK-3β (p-S9) increased in paclitaxel-resistant epithelial cells but decreased in resistant mesenchymal-like TNBC cells. Finally, chemotherapy resistance also activated p90 ribosomal S6 kinases (RSK1/2) in both cell types, while activation of mitogen- and stress-activated kinases (MSK1/2) was only observed in chemotherapy-resistant epithelial TNBC cells. These data reveal that chemotherapy resistance of epithelial and mesenchymal-like TNBC cellular subsets led to distinct profiles of proinflammatory and immune cell chemotactic cytokines and modulated the activities of GSK-3β, p90 RSK1/2 and the related MSK1/2. Targeting these factors and/or the associated signaling pathways may help overcome chemotherapy resistance in TNBC. - Source: PubMed
Publication date: 2026/03/31
Vuong Ngoc BKorolkova Olga YIzban Michael GSakwe Nobelle IMcIntosh Antonisha RBall Destiny DBlack Perrin JEdwards Alayjha DBallard Billy RAdunyah Samuel ESakwe Amos M - Calf health is becoming an increasingly important consideration for genetic selection in modern dairy cattle. However, the impact of calf diseases on other economically important traits and the genetic architecture underlying these traits remain poorly understood. This study aimed to (1) determine the impact of including calf disease traits into Canadian national genetic evaluation by estimating genetic and phenotypic correlations with other economically important traits, and (2) conduct a genome-wide association study and functional analysis to identify and understand genomic regions associated with calf disease traits in Holstein breed. The majority of genetic correlation estimates between calf diseases and other economically important traits were close to zero. However, notable correlations were found between respiratory problems and both fertility traits and clinical mastitis, which showed a favorable relationship. Similarly, estimated phenotypic correlations were generally small, suggesting limited phenotypic impact of calf disease on later life performance. These results highlight the importance of including calf disease traits within national evaluations to ensure improvements can be made on the genetic level. From the genome-wide association study, 17 single nucleotide polymorphisms (SNP) across 5 chromosomes were significantly associated with diarrhea, and 20 SNP across 5 chromosomes were significantly associated with respiratory problems. The enrichment analysis revealed 7 candidate genes that were co-localized with the SNP significantly associated with diarrhea (ACER3, CAPN5, ILK, LIPT2, PGM2L1, and PPME1). For respiratory problems, the enrichment analysis revealed 4 candidate genes that were co-localized with the significant SNP (SYNPO, DCTN4, ANXA6, and MYOZ3). Several potential candidate genes were identified, although further work is required to determine the exact association between identified genes and calf disease traits. - Source: PubMed
Publication date: 2026/04/03
Lynch CMakanjuola B OSchenkel F SMiglior FKelton DBaes C F - Periodontitis (PD) and metabolic dysfunction-associated steatotic liver disease (MASLD) were highly prevalent inflammatory disorders that frequently coexisted, yet the molecular basis of their comorbidity remained poorly defined. Here, we applied an integrative multi-omics strategy that combined bulk RNA sequencing, weighted gene co-expression network analysis, spatial transcriptomics, single-cell profiling, and machine learning. This approach identified 11 hub genes bridging immune activation and metabolic remodeling, among which Annexin A6 (ANXA6) emerged as a key cross-disease candidate. Spatial transcriptomics supported tissue-specific localization of the hub-gene signature, while single-cell analysis revealed selective enrichment of ANXA6 expression in γδ T cells. Notably, ANXA6-high γδ T cells exhibited enhanced signaling interactions with endothelial cells, suggesting immune-vascular crosstalk in PD-MASLD comorbidity. Upstream regulatory analysis further highlighted transcription factors associated with ANXA6 expression, and Connectivity Map-based prediction suggested candidate compounds with the potential to reverse ANXA6-associated transcriptional programs. Collectively, these findings support the hypothesis that ANXA6-high γδ T cell-endothelial communication represents a shared immunological feature of PD-MASLD comorbidity, offering novel insights into common immune programs and potential therapeutic opportunities. - Source: PubMed
Publication date: 2026/03/25
Zhang ZhongxuanMa ZihanZhang RuidongYe MinShi ZhongyuYu MiaoOu Lingling - Endoplasmic reticulum (ER) stress and oxidative stress are closely linked in driving the TGF-β1-mediated proliferation and myofibroblast differentiation of lung fibroblasts during pulmonary fibrosis. Silibinin (SIL), a bioactive compound derived from Silybum marianum l., has been proven to suppress inflammatory responses in a bleomycin (BLM) mouse model, but the protective mechanisms and specific molecular target through which SIL acts in pulmonary fibrosis remain unclear. - Source: PubMed
Publication date: 2026/03/05
Guan RuijuanZhang YingliWang ZhengyangHuang DanxiaBai YakunDeng MeifangLi KailinHu XiaoHuang FeiDai YingTian FangXu ZhiyuanYang TaoPeng GuilinXu Xin