Ask about this productRelated genes to: OR2C3 Blocking Peptide
- Gene:
- OR2C3 NIH gene
- Name:
- olfactory receptor family 2 subfamily C member 3
- Previous symbol:
- OR2C4, OR2C5P
- Synonyms:
- OST742
- Chromosome:
- 1q44
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-28
- Date modifiied:
- 2015-12-09
Related products to: OR2C3 Blocking Peptide
Related articles to: OR2C3 Blocking Peptide
- Autism spectrum disorder (ASD) has a strong genetic basis, yet its genetic complexities remain elusive. Current research highlights environmental factors and epigenetic processes, such as DNA methylation, as crucial in ASD development. This exploratory study addresses a gap in understanding epigenetic regulation in the dorsal raphe (DR)-a region regulating multiple neurotransmitters and implicated in ASD-by examining DNA methylation profiles in postmortem ASD and control brains. - Source: PubMed
Publication date: 2025/04/24
Iwata KeikoNakabayashi KazuhikoIshiwata KeisukeNakamura KazuhikoKameno YosukeHata KenichiroMatsuzaki Hideo - Disruption of circadian rhythm was found to be associated with immune infiltration and thyroid cancer. However, the role of clock circadian regulator (CLOCK) in the progression of thyroid cancer and its immune microenvironment remains largely unexplored. Therefore, our aim was to explore the role and potential mechanism of CLOCK in thyroid cancer. - Source: PubMed
Publication date: 2025/01/31
Shen ZhenZhao YueleiXu XinxinYang HuiniHe ShutingMa JunchiZhang ShaoqiangHou PengSui Fang - The Mexican American population is among the fastest growing aging population and has a younger onset of cognitive decline. This group is also heavily burdened with metabolic conditions such as hypertension, diabetes, and obesity. Unfortunately, limited research has been conducted in this group. Understanding methylation alterations, which are influenced by both genetic and lifestyle factors, is key to identifying and addressing the root cause for mild cognitive impairment, a clinical precursor for dementia. We conducted an epigenome-wide association study on a community-based Mexican American population using the Illumina EPIC array. Following rigorous quality control measures, we identified 10 CpG sites to be differentially methylated between normal controls and individuals with mild cognitive impairment annotated to PKIB, KLHL29, SEPT9, OR2C3, CPLX3, BCL2L2-PABPN1, and CCNY. We found four regions to be differentially methylated in TMEM232, SLC17A8, ALOX12, and SEPT8. Functional gene-set analysis identified four gene-sets, RIN3, SPEG, CTSG, and UBE2L3, as significant. The gene ontology and pathway analyses point to neuronal cell death, metabolic dysfunction, and inflammatory processes. We found 1,450 processes to be enriched using empirical Bayes gene-set enrichment. In conclusion, the functional overlap of differentially methylated genes associated with cognitive impairment in Mexican Americans implies cross-talk between metabolically-instigated systemic inflammation and disruption of synaptic vesicular transport. - Source: PubMed
Pathak Gita ASilzer Talisa KSun JieZhou ZhengyangDaniel Ann AJohnson LeighO'Bryant SidPhillips Nicole RBarber Robert C - Olfactory receptors (ORs) recognize odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell. This process also modulates the apoptotic cycle of olfactory sensory neurons in an olfactory receptor-specific manner. Recent reports indicate that some olfactory receptors are expressed in tissues other than the olfactory epithelium suggesting that they may have pleiotropic roles. We investigated the expression of 301 olfactory receptor genes in a comprehensive panel of 968 cancer cell lines. Forty-nine per cent of cell lines show expression of at least one olfactory receptor gene. Some receptors display a broad pattern of expression across tumour types, while others were expressed in cell lines from a particular tissue. Additionally, most of the cancer cell lines expressing olfactory receptors express the effectors necessary for OR-mediated signal transduction. Remarkably, among cancer cell lines, is exclusively expressed in melanoma lines. We also confirmed the expression of in human melanomas, but not in normal melanocytes. The pattern of expression is suggestive of a functional role in the development and/or progression of melanoma. Some olfactory receptors may contribute to tumorigenesis. - Source: PubMed
Publication date: 2017/02/10
Ranzani MarcoIyer VivekIbarra-Soria XimenaDel Castillo Velasco-Herrera MartinGarnett MathewLogan DarrenAdams David J