UCRC Blocking Peptide
- Known as:
- UCRC Blocking Peptide
- Catalog number:
- 33r-4946
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- UCRC Blocking Peptide
Related genes to: UCRC Blocking Peptide
- Gene:
- UQCR10 NIH gene
- Name:
- ubiquinol-cytochrome c reductase, complex III subunit X
- Previous symbol:
- -
- Synonyms:
- HSPC051, UCRC, QCR9, UCCR7.2
- Chromosome:
- 22q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 2010-01-26
- Date modifiied:
- 2014-11-19
Related products to: UCRC Blocking Peptide
Related articles to: UCRC Blocking Peptide
- Tetralogy of Fallot (TOF) is one of the most common cyanotic congenital heart diseases in infants and young children. Its molecular basis remains incompletely understood. This study aimed to identify mitochondrial energy metabolism-related candidate genes associated with pediatric TOF using public heart tissue transcriptomic datasets from the GEO database. - Source: PubMed
Publication date: 2026/06/14
Qin YuweiLang Tong - Improving feed efficiency has been the top priority in animal husbandry. Host genetics and gut microbiota synergistically regulate feed efficiency in laying chicken. However, the role of gut microbiota in heterosis for feed efficiency was rarely investigated. Herein, we used multi-omics data to elucidate the regulatory mechanisms of heterosis for feed efficiency in White Leghorn, Beijing-You chicken, and their reciprocal crosses. We observed divergent heterosis for residual feed intake (RFI) between two crossbreds during the laying period from 43 to 46 weeks of age. Metagenomic analysis showed the significant difference in richness and function of cecal microbiota among crossbreds and purebreds (P < 0.05), and the differential functional pathways were mainly related to metabolism. Most microorganisms (>90 %) were non-additive in crossbreds. Weighted gene co-expression network analysis and LDA effect size analysis revealed seven non-additive RFI-associated microorganisms, such as Leyella, Paraprevotella, and Zongyangia. We also identified 544 RFI-associted metabolites, which were mainly overrepresented in glycerophospholipid metabolism and oxidative phosphorylation. Integrative analysis further revealed the interactions among non-additive microorganisms, genes, and metabolites. Specifically, the non-additive expression of Zongyangia was positively correlated with UQCR10 and Ubiquinone-1 levels within the oxidative phosphorylation pathway. These factors were negatively correlated with RFI, contributing to the RFI heterosis. Our study highlighted that key microorganisms, genes, and metabolites involved in oxidative phosphorylation interact to regulate negative heterosis for RFI in laying hens. The findings established a theoretical and practical foundation for further exploring the molecular mechanisms that drive heterosis for feed efficiency. - Source: PubMed
Publication date: 2026/02/18
Li QinYuan JingweiSun YanyanWang YuanmeiLi YunleiNi AixinZong YunheYang HanhanLi XinyiHuang XiaolongMa HuiChen Jilan - A cell's transcriptome is regulated through the integration of external and internal signals that activate intracellular signal pathways, epigenetic modifications and post-translational changes. Post-transcriptional regulation through RNA methylation has emerged as an important mechanism in cancer development, and informative for diagnosis and treatment. The most abundant one, N6-methyladenosine (mA), regulates gene expression in eukaryotes. In the present study mA RNA modifications have been characterized in response to ionizing radiation (IR) exposure in the HT1080 human cell line. Cells were exposed to a dose of 10 Gy of X-rays and harvested 1, 2, 10 min, 1 and 24 h after exposure. mA sites were identified using long read nanopore direct RNA sequencing. A pipeline was designed using m6Anet to estimate mA stoichiometries transcriptome-wide, which were then analysed by a beta-binomial regression model with moderated dispersion estimates and independent filtering to detect differentially methylated (DM) sites between treated and control samples. We found that IR modifies mA sites in a dynamic way, inducing site specific increase of methylation. Remarkably, it peaks within the first minute after exposure, followed by a sharp decrease at 1 h without returning to baseline, increasing again after 24 h. Two transcripts of the nuclear encoded gene UQCR10, a subunit of the respiratory chain protein, sharing the same site presented a stable hypermethylation over time, confirmed by a modified quantitative PCR assay. Moreover, we generated Knockouts (KO) cell lines for 3 key enzymes involved in mA methylation, a writer, a reader and an eraser namely METTL3, YTHDF2 and FTO, to better understand mechanistically IR driven mA dynamics. Importantly, all three KOs presented a transcriptome wide decrease in RNA methylation following IR exposure. Lastly, mA modifications were also confirmed in human skin biopsies exposed to IR, with the UQCR10 gene site also hypermethylated 24 h after a lower 2 Gy X-rays dose. To summarise, we provide evidence that IR modulates RNA mA levels in a site-specific and dynamic way, with DM sites enriched in genes involved in bioenergetics, cell signalling/migration and apoptosis pathways, thus representing a rapid cellular response to radiation. Considering the essential role of mA in controlling gene expression and physiological activities, this study established the basis for further studies assessing IR driving mA with a potential role in radiation oncology and protection. - Source: PubMed
Publication date: 2026/03/02
Cruz-Garcia LDavies PhilipGoriacha VeronikaNajim MustafaPolozov StanislavPolozova MariaBadie Christophe - With the prevalence of Western-style high-fat diet (HFD), the incidence of heart failure with preserved ejection fraction (HFpEF) is gradually increasing. Recent studies suggested that microRNAs (miRNAs) located in different subcellular organelles could regulate lipid metabolism and cardiac function. However, the functional property of subcellular argonaute 2 (AGO2), the core member of miRNA machinery, remained elusive in HFD-related HFpEF. - Source: PubMed
Publication date: 2026/03/05
Jin KunyingTang YuyanZhan JiabingZhou YufeiXie RongHu GuoQin YatongWen JianpeiWen ZhengZhao YanruFan JiahuiDu HengzhiWang FengTang SuzhenYang ShaowenGuo Yusong RJiang DaweiWu JunfangLiu QianCheng XiangLi HuapingChen Chen - Tendinopathy is a common musculoskeletal disorder that increases the risk of tendon rupture if not properly treated. Current local injection therapies require frequent administration, and no fully effective drug is yet available. Curcumin (Cur) exhibits excellent anti-inflammatory and antioxidant effects, but its poor water solubility and low stability limit its clinical application. To overcome these challenges, this study encapsulated Cur into pluronic F127-based nanomicelles (Cur-F127) to improve its aqueous solubility and stability. Subsequently, the micelles were incorporated into a hydrogel network (Cur-F127&gel) formed by oxidized hyaluronic acid (oxi-HA) and adipic acid dihydrazide (ADH) to achieve sustained release. The resulting Cur-F127 micelles had a particle size of 20.14 ± 0.287 nm, an encapsulation efficiency (EE%) of 89.95 ± 0.60%, and a drug loading (DL%) of 5.57 ± 0.05%. The composite hydrogel possessed a loose, porous three-dimensional network, excellent biocompatibility, and favorable degradation behavior. The system enabled sustained release of Cur for over 20 days without an initial burst. In a rat model of tendinopathy, Cur-F127&gel significantly promoted tendon repair, as evidenced by reduced inflammatory cell infiltration, improved collagen fiber alignment, restored expression of key mitochondrial-related proteins (Ndufs3, Uqcrq, Uqcr10, Atp5mc3), and alleviated oxidative stress damage demonstrated by increased SOD activity and decreased MDA content in tendon tissue, thereby suppressing disease progression. This injectable sustained-release hydrogel system for poorly soluble drugs provides an effective approach for the local, long-acting delivery of Cur and long-term repair of tendinopathy, highlighting its potential value for clinical application. - Source: PubMed
Publication date: 2026/02/07
Wang ShuangWu KeyiSun MeiqiWang XinruiLi JingyingZhang GuorongQiu Zhidong