Ask about this productRelated genes to: RBPMS Blocking Peptide
- Gene:
- RBPMS NIH gene
- Name:
- RNA binding protein, mRNA processing factor
- Previous symbol:
- -
- Synonyms:
- HERMES
- Chromosome:
- 8p12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-02-25
- Date modifiied:
- 2018-01-04
Related products to: RBPMS Blocking Peptide
Related articles to: RBPMS Blocking Peptide
- To investigate the changes in the neurovascular unit (NVU) of the retina in rats following optic nerve (ON) injury, and to explore the translational implications for traumatic optic neuropathy (TON). - Source: PubMed
Publication date: 2026/06/09
Wu QiongWang HuiLiu HongJuanZhang LuyinWei Qiping - While Nectin-3 is a recognized marker for maintaining stem and progenitor "side populations" in non-neural epithelia, its role and distribution within the mammalian retina remain largely uncharacterized. Identifying such rare populations is a critical step toward unlocking the regenerative potential of the retina after injury. This study provides a comprehensive spatiotemporal characterization of Nectin-3 cells from embryonic development through adulthood. Using fluorescence-activated cell sorting, a distinct Nectin-3 population was identified across all examined stages, representing 1.27% ± 0.24 of viable cells at E18, peaking at P5 (3.62% ± 0.58), and persisting in the adult retina (1.43% ± 0.14). At this mature stage, triple-positive (Nectin-3/CD117/Sca-1) cells displayed a robust molecular signature defined by the significant up-regulation of Chx10, Nestin, Pax6, Rax, and the RGC marker Rbpms, despite a lack of synaptic transcript (Syp) enrichment. Morphological analysis via confocal microscopy demonstrated that Nectin-3 cells undergo dynamic changes during development. In the adult retina, these cells showed colocalization with RBPMS, while remaining distinct from the Müller glial scaffold. Principal Component Analysis highlighted that adult cells retain transcriptional features typically associated with early development, indicating a specialized neuronal identity that is molecularly distinct from the surrounding retinal environment. By defining this fraction, we provide a practical tool for studying retinal diversity and a foundation for investigating the potential regenerative capacity of these rare cells. - Source: PubMed
Publication date: 2026/06/08
Lukomska AgnieszkaKieszek PatrycjaBuczek NataliaRatajczak Mariusz ZKucia Magdalena - Accurate identification of gene fusions is critical for precision oncological approaches to sarcomas, where specific fusion genes are actionable targets of tyrosine kinase (TK) inhibitors. This study provides a descriptive overview of the real-world use, under a universal health insurance program, of 3 different comprehensive genomic profiling (CGP) panels within the Japanese national CGP system: GenMineTOP, which integrates DNA and RNA sequencing, and 2 DNA-based panels, FoundationOne CDx and the OncoGuide NCC Oncopanel System. - Source: PubMed
Publication date: 2026/05/27
Kamio SatoshiIkegami MasachikaKitada RinaMiwa SatoshiOgura KoichiIwata ShintaroKawai AkiraKobayashi EisukeSuehara YoshiyukiKohsaka Shinji - Leukemia is a malignant tumor with a high recurrence rate and poor prognosis for patients. Thus, there is an urgent need to explore new therapeutic targets that play critical roles in leukemogenesis but have little effect on normal hematopoietic cells. Here, we show that RNA binding protein with multiple splicing (RBPMS), which is highly expressed in acute myeloid leukemia (AML) and associated with poor prognosis of AML, plays critical roles in leukemogenesis. Our study shows that inhibition of RBPMS inhibits self-renewal of leukemia-initiating cells (LICs) and leukemia development but has little effect on normal hematopoiesis. Mechanistically, RBPMS recruits the -methyladenosine (mA) reader insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3), which promotes the stability of the () mRNA in an mA-dependent manner. Moreover, RBPMS contributes to the progression of leukemia by directly binding to and promoting FOXO1-regulated glycolysis. Overexpression of FOXO1 has been shown to reverse RBPMS inhibition-induced phenotypes in both leukemic cells and mouse models. We also designed a specific inhibitor of RBPMS that has therapeutic effects in AML patient-derived xenograft (PDX) models. We therefore highlight RBPMS as a promising drug target for leukemia therapy. - Source: PubMed
Publication date: 2026/05/06
Liu PingZhang SulinChen Bing-YiChang BinheJiang YilunLi XiyaChen XinchiLi Zi-JuanYang RuiruiWang XiaoningXu Chun-HuiLiu XiaomengLiu NaJia YuanyuanYu Peng-ChengWang YongZong Li-JuanHu Cheng-LongHou HuiCao DuanhuaLi XutongDeng Chu-HanRen Yi-YiZhao Mu-YingMa XinyiCui RongrongTeng DanChen MiaoWang RoujiaJin JiachengJiang Shi-YuYan XiaojingXue KaiZhang QunlingLi JianfengDai EnyongShen ShuhongWang ZhikaiYe XueshiZhang JinLiu YuCui WenguoLu MinZhao Wei-LiChang Chun-KangHe Peng-ChengChen ZhuChen Sai-JuanZheng MingyueSun Xiao-JianWang Lan - This study examines whether the response of the rat optic nerve tissue to either acute or chronic intraocular pressure (IOP) elevation is affected when optic nerve sheath pressure is reduced via optic nerve sheath fenestration. - Source: PubMed
Ganearachchi Sera NZhao DaWong Vickie H YLee Pei YingAfiat Brianna CNguyen Christine T OBui Bang V