Ask about this productRelated genes to: CACNB4 Blocking Peptide
- Gene:
- CACNB4 NIH gene
- Name:
- calcium voltage-gated channel auxiliary subunit beta 4
- Previous symbol:
- -
- Synonyms:
- EJM4
- Chromosome:
- 2q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1997-04-21
- Date modifiied:
- 2016-02-04
Related products to: CACNB4 Blocking Peptide
Related articles to: CACNB4 Blocking Peptide
- The beneficial effects of bone marrow mesenchymal stem cells (BMSCs) have been linked to their secreted extracellular vesicles (EVs). These EVs can suppress cartilage degradation and prevent apoptosis in articular cells. We aimed to explore the therapeutic efficacy of engineered BMSCs-EVs in the treatment of osteoarthritis (OA). - Source: PubMed
Publication date: 2026/07/10
Zhang YunqiWang FusenYu HuanJiang ChangqingLi ZhongBu RongqiangYu Jun - Juvenile Polyposis Syndrome (JPS) is an autosomal dominant disorder characterized by multiple gastrointestinal polyps and an increased risk of cancer, most commonly associated with mutations in the tumor suppressor gene . However, substantial phenotypic variability exists among individuals carrying identical mutations, suggesting the presence of genetic modifiers. In this study, we used the genetically diverse Collaborative Cross (CC) mouse population crossed with Smad4 knockout mice to identify loci influencing intestinal polyp development. A cohort of 260 F1 mice derived from 14 CC lines was assessed for polyp number and size across intestinal segments. Quantitative trait locus (QTL) mapping revealed several significant loci, including regions on chromosomes 16, 14, and 12, which were designated 1, 2, and 3 for Intestinal Polyposis Susceptibility locus (), respectively, in the full population, as well as additional sex-specific loci in male and female cohorts. Pathway enrichment analysis of genes within these regions highlighted functional associations with immune signaling, ubiquitin-proteasome degradation, and metabolic regulation. Candidate genes, including , , , and , emerged as potential modifiers of polyp susceptibility. These findings highlight the complex genetic architecture underlying JPS phenotypes and provide candidate loci for future functional and translational investigations. - Source: PubMed
Publication date: 2026/05/07
Zohud OsaydMidlej KreemLone Iqbal MNashef AysarAbu-Elnaaj ImadIraqi Fuad A - To explore the clinical features and molecular genetic characteristics of epilepsy related to fever sensitivity caused by various types of gene mutations, and to analyze the relationships of genotype and clinical phenotype with clinical treatment efficacy. - Source: PubMed
Publication date: 2026/04/09
Wang YanpingZhang LinMa JingboJing MiaoHua YingLiu YanshanFan Xiaochun - To identify and validate druggable gene targets for periodontitis using integrative human genomic analyses and to explore their therapeutic potential through pharmacological evaluation. - Source: PubMed
Publication date: 2026/01/07
Jiang YixuanGuan ZhengyuYao XiuLiu XiaomengQiu DanSun BoyuanLi Hongjiao - Chinese Simmental cattle serve as an important dual-purpose breed in sustainable livestock systems. Despite their economic value, the genetic architecture underlying milk-production traits in this breed under temperate conditions remains poorly characterized. In this study, we estimated genetic parameters and identified associated genomic loci for 9 milk-production traits in a Chinese Simmental population. Our dataset consisted of 17,556 test-day records from 1,788 cows (parities 1 to 3), including whole-genome sequencing data for 781 individuals. Using a random regression test-day model with Legendre polynomials, we estimated variance components, heritabilities, breeding values (EBVs), and genetic correlations between different DIM. Heritability estimates ranged from 0.09 (fat-to-protein ratio) to 0.52 (protein percentage), with intermediate values for fat percentage (0.28), lactose percentage (0.35), and total milk solids (0.35). Within-lactation genetic correlations varied by trait, ranging from -0.88 to 0.99, with the strongest correlations between adjacent DIM, which weakened as intervals widened. Genome-wide association analysis (using the mixed linear model in SLEMM version 0.90.1) and Bayesian fine-mapping analysis identified significant SNPs near known candidate genes (BOP1, MROH1, NEGR1). These analyses also revealed putative novel associations with CACNB4, MTHFD2L, and SGMS1. Overall, the results enhance our understanding of the genetic regulation of milk production and provide practical targets for genomic selection to improve dairy performance in dual-purpose breeding programs. - Source: PubMed
Publication date: 2025/12/18
Dong ChunxiaoMa PeipeiTang YongjieHan HaoqiChen SiqianYang JiaziSun ZhigangWang WeiYu YingLi Shengli