Ask about this productRelated genes to: RGL3 Blocking Peptide
- Gene:
- RGL3 NIH gene
- Name:
- ral guanine nucleotide dissociation stimulator like 3
- Previous symbol:
- -
- Synonyms:
- FLJ32585
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-11
- Date modifiied:
- 2018-11-19
Related products to: RGL3 Blocking Peptide
Related articles to: RGL3 Blocking Peptide
- Cytokinin and gibberellin are two plant hormones promoting flowering in Arabidopsis thaliana grown under short-day conditions. The activities of both hormones depend on similar signaling components, including several elements of the age pathway. However, to date, the interaction between cytokinin and gibberellin in regulating the transition to flowering remains unknown. In this work, we show that exogenous treatment of late-flowering or non-flowering cytokinin mutants by gibberellin restores their ability to flower. In contrast, the promotion of flowering by cytokinin is suppressed by mutations in gibberellin biosynthesis genes, and cytokinin-deficient plants show reduced expression of these genes. Consistently, cytokinin-deficient plants show an altered gibberellin homeostasis in leaves and shoot apices. Simultaneous mutation of the DELLA genes GAI and RGA, or of RGL1 and RGL3, caused earlier flowering in cytokinin receptor mutants. This is consistent with their downstream activity in response to cytokinin and reveals a previously unrecognized role for these genes in regulating flowering time. Together, the results indicate that cytokinin acts upstream of a redundant network of gibberellin metabolism and signaling genes and suggest that hormonal crosstalk occurs in both leaves and the shoot apical meristem. Cytokinin action through different elements of the gibberellin system underscores the complexity of hormonal interactions in controlling the floral transition. - Source: PubMed
Publication date: 2026/06/11
Werner SörenBartrina IsabelTarkowská DanušeWerner TomášSchmülling Thomas - Stone cells originate from secondary cell wall thickening and contain abundant lignin. Their excessive accumulation compromises pear fruit quality, yet the endogenous hormonal mechanisms governing stone cell formation remain unclear. Here, co-expression network analysis using transcriptome data - the flesh of 206 sand pear accessions sampled at the critical stage of stone cell formation and multitissues of 'Dangshansuli' - showed that auxin biosynthetic gene YUCCA6 and auxin signaling activator ARF6 were strongly co-expressed with lignin-related genes. A positive correlation was observed between endogenous indole-3-butyric acid (IBA) levels and the rate of stone cell accumulation. Moreover, both YUCCA6 overexpression and exogenous IBA treatment enhanced lignin deposition in pear, demonstrating that auxin promoted stone cell lignification. Additionally, ARF6 promoted stone cell lignification. Mechanistic analyses revealed that ARF6 activated HB49, which subsequently upregulated MYB169, a key transcriptional activator of lignin biosynthesis, thereby promoting stone cell lignification. Notably, ARF6 interacted with repressors IAA27 or RGL3, which suppressed HB49 activation; this repression was alleviated by auxin or gibberellin treatment, which restored ARF6-mediated activation of HB49. These results establish ARF6 as an integrator of auxin and gibberellin signaling pathways and provide new mechanistic insights into auxin-gibberellin crosstalk in regulating stone cell lignification. - Source: PubMed
Publication date: 2026/04/27
Shan YanfeiChen ShulinCai JianfaZhou ZhengPan ChongLiu JiahaoZheng PengfeiLi ChengLiu YueyuanXue ChengWu Jun - Understanding the development of midbrain dopaminergic (mesDA) neurons is essential for advancing cell replacement therapies for Parkinson's disease. In the developing ventral midbrain (VM), radial glia (Rgl) cells are the progenitors of mesDA neurons. However, distinct Rgl subtypes have recently been identified, and their individual roles are unclear. Here we analyze transcriptomic data from mouse and human VM Rgl to define their contributions to mesDA neuron development. We identify Rgl1 as the progenitor of the mesDA lineage, and reveal a Rgl1 transcriptional network coordinated by BMAL1, which we validate as a new regulator of mesDA neurogenesis. Moreover, we uncover Rgl3 as a key signaling subtype and show that factors expressed by Rgl3 promote the survival and yield of human stem cell-derived mesDA neurons. Our findings delineate distinct roles of Rgl subtypes, elucidate lineage relationships in the developing VM and uncover new factors that improve the derivation of clinically relevant human mesDA neurons. - Source: PubMed
Publication date: 2026/02/16
Ásgrímsdóttir Emilía SifBassini Luca FusarSun TingPuigsasllosas Pastor Clàudiadi Val Cervo Pia RivettiGyllborg DanielLee KawaiGrigsby Christopher LJude BaptisteAbaurre CarmenIslam SaifulLönnerberg PeterVillaescusa CarlosSaltó CarmenBarker Roger ALinnarsson StenCastelo-Branco GoncaloLa Manno GioeleToledo Enrique MArenas Ernest - Hypertension is influenced by both genetic and dietary factors. Understanding gene-diet interactions across populations is key to precision prevention. - Source: PubMed
Publication date: 2026/01/08
Hur Haeng JeonYang Hye JeongKim Min JungJang Hyun-JunKim Myung-SunnyPark Sunmin - Stone cells are a remarkable trait of pear (Pyrus spp.) fruit, with their abundance directly affecting fruit quality and varying significantly among cultivars. While plant hormones influence fruit development, their role in stone cell formation remains poorly understood. Here, we conducted a co-expression network analysis using RNA-seq data from 206 pear (Pyrus pyrifolia), linking hormone biosynthesis genes with known regulators of stone cell formation. This analysis identified that gibberellin (GA) 2-oxidase 1-1 (GA2ox1-1), a GA oxidase gene whose expression correlates significantly with stone cell content across cultivars, increases during key developmental stages, and localizes specifically to stone cells, as revealed by RNA in situ hybridization. Functional validation showed that expression of GA2ox1-1 in pear fruit, callus, and Arabidopsis (Arabidopsis thaliana) resulted in significantly lower lignin content and markedly lower active GA levels. To elucidate the GA-mediated regulation of stone cell lignification, we identified the DELLA protein REPRESSOR of ga1-3 Like 3 (RGL3), a key component of the GA signaling pathway. RGL3 interacts with myeloblastosis transcription factor MYB169, a known positive regulator of lignin biosynthesis, and suppresses MYB169-mediated activation of lignin biosynthesis genes, thereby negatively regulating lignin biosynthesis. However, in the presence of GA, RGL3 inhibition was relieved, leading to MYB169 activation, upregulation of lignin biosynthesis genes, and enhanced lignin deposition. These findings clarify the role of GA in stone cell formation and reveal a regulatory mechanism involving the RGL3-MYB169 module. This work provides insights into modulating stone cell content to improve pear fruit quality. - Source: PubMed
Zheng PengfeiCai JianfaXue YongsongZhang XiangWang ZikangXu ShaozhuoPan ChongWang RunzeXue ChengWu Jun