Ask about this productRelated genes to: CHI3L1 Blocking Peptide
- Gene:
- CHI3L1 NIH gene
- Name:
- chitinase 3 like 1
- Previous symbol:
- -
- Synonyms:
- GP39, YKL40, YK-40
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-20
- Date modifiied:
- 2018-08-01
Related products to: CHI3L1 Blocking Peptide
Related articles to: CHI3L1 Blocking Peptide
- Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Type 1 Diabetes (T1D), but a subset of individuals remains free from macrovascular or renal complications despite decades of hyperglycaemia and a significant risk factor burden. We used a targeted proteomic approach (Olink Cardiovascular panel III, targeting 92 proteins) to characterize the proteomic profile of cardiovascular resilience in T1D by comparing 92 patients with long-standing T1D (age 59.8 [53.2, 69.1], duration 40.0 [35.0, 45.2] years) free from macrovascular complications or nephropathy against a reference group of 57 T1D patients with accelerated vascular pathology (age 42.0 [32.0, 56.0], duration 22.0 [18.0, 27.0] years), proliferative retinopathy and/or nephropathy in relation to diabetes duration, termed Rapid Progressors (RP). Twenty proteins differed significantly between RP and Escapers (False Discovery Rate [FDR] < 0.05) after adjustment for age, sex, HbA1c, and eGFR: Caspase-3 was significantly higher in RP (Adjusted difference: + 2.12 Normalized Protein eXpression [NPX], p < 0.001). Proteins associated with platelet activation and leukocyte adhesion with increased levels in RP included Junctional Adhesion Molecule A (+ 1.40 NPX), Glycoprotein VI (GP6: + 1.29 NPX), and P-Selectin (+ 0.82 NPX) (all p < 0.001). PECAM-1 (+ 0.55 NPX) and TNFRSF14 (+ 0.43 NPX), were also elevated. RP also showed higher levels of metabolic and tissue-remodelling proteins; Transferrin Receptor (+ 0.53 NPX) and Fatty Acid Binding Protein 4 (+ 0.52 NPX), as well as higher Bleomycin Hydrolase, Trefoil Factor 3, GDF-15, U-PAR, and Cystatin B. Conversely, von Willebrand Factor (vWF) levels (- 1.35 NPX, p < 0.001) and Paraoxonase 3 (PON3) was lower in RP (- 0.34 NPX, p = 0.003). In conclusion, escaping complications in long-term T1D appears to be associated with active molecular mechanisms. Progression is marked by apoptosis (Caspase-3), fibrosis (CHI3L1) and platelet activation (GP6), whereas resilience is associated with a distinct signature involving higher vWF and PON3. These findings highlight a profound biological divergence between extreme T1D phenotypes and provide a foundation for further research into vascular resilience. - Source: PubMed
Publication date: 2026/06/20
Ekström OlaKennbäck CeciliaLyssenko ValeriyaLöndahl MagnusChristensson AndersNilsson Peter MGottsäter Anders - To evaluate tear CHI3L1 (tCHI3L1) as a minimally invasive biomarker in multiple sclerosis (MS), compare it with serum and cerebrospinal fluid (CSF) CHI3L1, and assess associations with clinical phenotype and disease measures. - Source: PubMed
Publication date: 2026/06/10
Castillo-Villalba JéssicaGasque-Rubio RaquelForés-Toribio LorenaTortosa-Carreres JordiGarcía-Lluch GemmaFerrer-Pardo CristinaCarratalá-Boscá SaraAlcalá CarmenGorriz DavidQuintanilla-Bordás CarlosPoyatos-García JavierCasanova BonaventuraCubas-Núñez LauraPérez-Miralles Francisco - At the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2025 annual meeting in Bogotá, Columbia, Alexandra Khmelevskaya and Dr. Christopher Ritchlin presented a basic symposium on synovial immunopathology. They presented a comparative analysis between rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Their multiomic studies revealed that RA is characterized by heightened intercellular signaling, particularly involving secreted phosphoprotein 1-positive (SPP1+) macrophages, chitinase-3-like protein 1-positive (CHI3L1+) fibroblasts, and fatty acid binding protein 5-positive inflammatory dendritic cell type 3 (FABP5+ iDC3]). Spatial transcriptomics confirmed direct, contact-dependent interactions between SPP1+ macrophages and iDC3 specifically in RA, whereas CHI3L1+ fibroblasts interacted with iDC3 through soluble mediators. Multiplex immunofluorescence validated the tissue localization of these subsets. In contrast, PsA was distinguished by transcriptionally activated CD8+ T cells in both synovium and peripheral blood, with open chromatin states indicating preactivation prior to tissue infiltration. These findings delineate RA-specific stromal-myeloid-dendritic cell networks and PsA-specific T-cell activation programs. Together, they underscore distinct immunopathogenic mechanisms and provide potential targets for precision therapeutics in inflammatory arthritis. - Source: PubMed
Publication date: 2026/06/15
Khmelevskaya AlexandraRitchlin ChristopherOspelt CarolineMicheroli Raphael - Alzheimer's disease (AD) plasma and cerebrospinal fluid (CSF) proteomics can distinguish AD from cognitively normal controls, but the generalizability of machine learning performance and the recurrence of biological signals across datasets require cautious interpretation. We developed an explainable artificial intelligence framework spanning two fluids and four ADNI proteomic datasets, covering 2082 modality specific samples, all analysed internally within ADNI. Phase 1 analysed plasma using a 119 analyte NULISA and targeted UPENN panel (n = 727; 216 CE, 511 controls). Phase 2 extended the analysis to CSF using SOMAscan7k, TMT-MS and targeted SET2, with Elecsys Aβ42, Aβ40, total tau and p-tau181 as anchor biomarkers. Only SOMAscan was subject-independent relative to Phase 1 plasma; TMT-MS and SET2 overlapped with Phase 1 for 96.0% and 97.7% of subjects and therefore are not independent replication cohorts. Under subject-level splits with fold internal preprocessing, we compared Elastic Net, Explainable Boosting Machines and gradient boosted trees with SHAP-based explanations. Among the candidate pipelines, we selected the pipeline with the highest held-out test ROC AUC for each platform; the selected values were 0.927 in plasma and 0.954-0.973 across the three CSF datasets. Because the same held out test performance was used for pipeline selection and headline reporting, these are optimistically selected single-holdout estimates, not unbiased estimates of generalizable or clinical performance. Explanations identified five recurring biological axes within ADNI: cholinergic (ACHE), tau/14-3-3 (YWHAG, YWHAZ, YWHAB, YWHAE), neuro-axonal (NEFL, NEFH), microglial/complement (CHIT1, SMOC1, CHI3L1, C7, CFH) and synaptic (NPTXR, NPTX2, DLG4, SYT5, VSNL1, ELAVL2). CSF analyses showed synaptic vesicle-cycle enrichment (q = 2 × 10), and CSF YWHAG correlated strongly with total tau (ρ = 0.87). Cross-fluid directional concordance was modest overall (54-57%) but increased to 73-80% among mapped analyte/protein rows reaching q < 0.05 in CSF. These findings provide hypothesis-generating, internally supported evidence within ADNI. Independent external cohorts with locked pipelines are required to evaluate generalizable performance and biological reproducibility; the overlapping TMT-MS and SET2 analyses should not be interpreted as independent replication. - Source: PubMed
Publication date: 2026/06/15
Donmez Turker BerkMansour Mohammed - Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) plaques, hyperphosphorylated tau tangles, and significant neuronal loss. Recent studies have implicated YKL-40, a glycoprotein commonly associated with inflammation and neural apoptosis, in the pathogenesis of AD. - Source: PubMed
Publication date: 2026/06/08
Sha YaruFu HongLu KunWang GuohuiWang Yubing