Ask about this productRelated genes to: GLYATL2 Blocking Peptide
- Gene:
- GLYATL2 NIH gene
- Name:
- glycine-N-acyltransferase like 2
- Previous symbol:
- -
- Synonyms:
- BXMAS2-10, MGC24009
- Chromosome:
- 11q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-11
- Date modifiied:
- 2015-11-18
Related products to: GLYATL2 Blocking Peptide
Related articles to: GLYATL2 Blocking Peptide
- Moll glands, found in the margin of the eyelid next to the base of the eyelashes, are likely to play an important role in maintaining the tear film and therefore in securing adequate visual function. However, information about their secretion and its regulation is extremely scarce. Here, we subjected spatial transcriptome data of the human eyelid to bioinformatics workflows incorporating machine learning to shed light on the Moll-specific transcriptional program. We identified Moll-specific genes such as HPD, CYP4Z1, PIP, GLYATL2, or SCGB2A2, which delineate a transcriptional core, i.e. not shared with other eyelid elements. Gene ontology enrichment analyses further depicted the biological functions of the Moll gland transcriptional programs, which include tyrosine metabolism and biosynthesis, extracellular exosome, small molecule metabolism, and erythrose 4-phosphate/phosphoenolpyruvate-family amino acid metabolism. Expression of GLYATL2 and HPD, identified as a specific and sensitive transcripts in the Moll gland transcriptome, was confirmed by immunofluorescence in the eyelid of four different patients, thus supporting the validity of our approach. Collectively, these results indicate that Moll-associated gene sets exhibit distinct but complementary functional programs, reflecting the gland's specialized metabolic capacity and secretory function within the eyelid tissue microenvironment. Our study provides the first in-depth analysis of the human Moll gland transcriptional landscape and identifies novel targets for regulating Moll gland homeostasis in health and disease. - Source: PubMed
Konecny TomasBinder HansHampel UlrikeHansmann FlorianPfannkuche HelgaSchneider Marlon R - Differences in skin and hair phenotypes between the scapular and ventral regions of yaks (Bos grunniens) are obvious and become more prominent with age. However, the genetic mechanism that causes differences in yak skin at different ages has not been reported. In this study, we investigated the transcriptomic profile of yak skin across different ages (0.5 years, 2.5 years, and 4.5 years) and body sites (scapular and ventral regions). Differential gene expression analysis was initially conducted to explore the transcriptomic differences in skin at different ages and different body sites. Subsequently, weighted gene co-expression network analysis (WGCNA) was employed to analyze the transcriptomic data comprehensively. The results showed that, among all comparison groups, the Y2.5_S vs. Y2.5_V group (regional comparison) exhibited the highest number of DEGs, with 491 genes (179 upregulated and 312 downregulated), followed by the Y2.5_V vs. Y0.5_V group (age comparison), which had 370 DEGs (103 upregulated and 267 downregulated). DEGs such as , , , and were found in all comparison groups of different ages, and multiple members of the HOX gene family including , , , , and were differentially expressed in comparison groups at different sites. Functional enrichment analysis showed that there were more obvious differences in immune function between different ages of skin and more obvious differences in endocrine function between different parts of skin. WGCNA revealed that genes related with immunity such as , , and were the core genes of the co-expression module associated with the scapula region, and multiple genes related to hair follicle development such as , , , , and were found to be the hub genes of the co-expression module associated with the ventral region. Overall, our study provides valuable insights into the transcriptomic complexity of yak skin across different ages and body sites. The differential gene expression patterns and co-expression network modules identified in this study lay the foundation for further research on skin biology and adaptation mechanisms in yaks. - Source: PubMed
Publication date: 2025/05/11
Zhang XiaolanShi BingangZhao ZhidongDeng YunqiZhou XuelanHu Jiang - Circadian rhythm-related genes (CRRGs) play essential roles in cancer occurrence and development. However, the prognostic significance of CRRGs in breast cancer (BC) has not been fully elucidated. Our study aimed to develop a prognostic gene signature based on CRRGs that can accurately and stably predict the prognosis of BC. - Source: PubMed
Chu MingyuHuang JingWang QianyuFang YaqunCui DinaJin Yucui - Dysregulation of fatty acid metabolism (FAM) represents a significant metabolic alteration in tumorigenesis. However, the role of FAM-related genes (FAMRGs) in early-stage lung squamous cell carcinoma (LUSC) remains incompletely understood. - Source: PubMed
Publication date: 2024/02/20
Xu JuqingYu MaoranFan WeifeiFeng Jifeng - Intracranial chordomas (ICs) are associated with a poor prognosis due to low total resection rates and high recurrence rates. However, the role of immunotherapy in ICs remains unknown. RNA sequencing and immunohistochemical staining were performed on IC tissues and normal tissues, and the long noncoding RNA (lncRNA) lnc-GLYATL2-2 was identified. The results indicated that high expression of lnc-GLYATL2-2 was positively correlated with the tumor-infiltrating lymphocyte (TIL) markers CD4 and Foxp3, negatively correlated with CD8, and positively correlated with the expression of the immune checkpoint molecules programmed death receptor-1 (PD-1) and programmed death ligand 1 (PD-L1). Additionally, Kaplan-Meier and univariate or multivariate Cox regression analyses revealed the predictive value of lnc-GLYATL2-2 for survival based on clinical data from patients with ICs. A high expression level of lnc-GLYATL2-2 is potentially correlated with a suppressive tumor immune microenvironment and adverse clinical outcomes in IC patients. Mechanistically, the upregulation of lnc-GLYATL2-2 can result in increased cytoplasmic levels of ELAVL1, leading to enhanced binding to the 3'-UTR of PD-L1 mRNA and maintenance of its stability. In contrast, lnc-GLYATL2-2 can directly interact with the PD-L1 protein to prevent degradation, thereby promoting high levels of PD-L1 expression simultaneously at the transcriptional and translational levels in chordoma cells. These results provide a new perspective on the diagnosis and prognosis of ICs and provide theoretical evidence for immunotherapy in patients with ICs. - Source: PubMed
Publication date: 2023/12/15
Wang ChengbinLiu YingliangCui DamingJiang YangLi Li