Ask about this productRelated genes to: KCNS1 Blocking Peptide
- Gene:
- KCNS1 NIH gene
- Name:
- potassium voltage-gated channel modifier subfamily S member 1
- Previous symbol:
- -
- Synonyms:
- Kv9.1
- Chromosome:
- 20q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1998-04-06
- Date modifiied:
- 2016-10-05
Related products to: KCNS1 Blocking Peptide
Related articles to: KCNS1 Blocking Peptide
- The aim of the study was to evaluate for associations between the occurrence of palpitations in women prior to breast cancer surgery and single nucleotide polymorphisms (SNPs) for potassium channel genes. - Source: PubMed
Publication date: 2025/10/15
Sheng YingFleming Matthew RHarris Carolyn JLevine Jon DPaul Steven MCarpenter Janet SConley Yvette PShin JoosunOppegaard KateHammer Marilyn JMiaskowski Christine - Post-amputation pain (PAP) is an umbrella term that includes residual limb pain (RLP) and phantom limb pain (PLP), posing a significant challenge to recovery and quality of life after limb loss. Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, has gained interest for its potential to manage PAP, particularly in refractory cases. This narrative review explores the efficacy of ketamine for PAP and the emerging role of pharmacogenomics in guiding its use. - Source: PubMed
Publication date: 2025/08/22
Tappe AlixBurzynski EmilyPatel JhanviCheyne IthamarMikaszewska-Sokolewicz Małgorzata - KvS proteins are voltage-gated potassium channel subunits that form functional channels when assembled into heteromers with Kv2.1 () or Kv2.2 (). Mammals have 10 KvS subunits: Kv5.1 (), Kv6.1 (), Kv6.2 (), Kv6.3 (), Kv6.4 (), Kv8.1 (), Kv8.2 (), Kv9.1 (), Kv9.2 (), and Kv9.3 (). Electrically excitable cells broadly express channels containing Kv2 subunits and most neurons have substantial Kv2 conductance. However, whether KvS subunits contribute to these conductances has not been clear, leaving the physiological roles of KvS subunits poorly understood. Here, we identify that two potent Kv2 inhibitors, used in combination, can distinguish conductances of Kv2/KvS heteromers and Kv2-only channels. We find that Kv5, Kv6, Kv8, or Kv9-containing channels are resistant to the Kv2-selective pore-blocker RY785 yet remain sensitive to the Kv2-selective voltage sensor modulator guangxitoxin-1E (GxTX). Using these inhibitors in mouse superior cervical ganglion neurons, we find predominantly RY785-sensitive conductances consistent with channels composed entirely of Kv2 subunits. In contrast, RY785-resistant but GxTX-sensitive conductances consistent with Kv2/KvS heteromeric channels predominate in mouse and human dorsal root ganglion neurons. These results establish an approach to pharmacologically distinguish conductances of Kv2/KvS heteromers from Kv2-only channels, enabling investigation of the physiological roles of endogenous KvS subunits. These findings suggest that drugs which distinguish KvS subunits could modulate electrical activity of subsets of Kv2-expressing cell types. - Source: PubMed
Publication date: 2025/05/27
Stewart Robert GMarquis Matthew JamesJo SooyeonHarris Brandon JAberra Aman SCook VerityWhiddon ZacharyYarov-Yarovoy VladimirFerns MichaelSack Jon T - Corticosteroid receptors, including mineralocorticoid receptor (MR) and glucocorticoid receptor (GR), play important roles in inflammatory pain in the dorsal root ganglion (DRG). Although it is widely known that activating the GR reduces inflammatory pain, it has recently been shown that MR activation contributes to pain and neuronal excitability in rodent studies. Moreover, little is known about the translation of this work to humans, or the mechanisms through which corticosteroid receptors regulate inflammatory pain. - Source: PubMed
Qualls Katherine AKadakia Feni KSerafin Elizabeth KLückemeyer Debora De NardinDavidson SteveStrong Judith AZhang Jun-Ming - Shortness of breath is a common symptom in patients with cancer. However, the mechanisms that underlie this troublesome symptom are poorly understood. Therefore, this study aimed to determine the prevalence of and associated risk factors for shortness of breath in women prior to breast cancer surgery and identify associations between shortness of breath and polymorphisms for potassium channel genes. - Source: PubMed
Publication date: 2024/08/13
Shin JoosunHammer Marilyn JPaul Steven MConley Yvette PHarris CarolynOppegaard KateMorse LisaCooper Bruce ALevine Jon DMiaskowski Christine