Ask about this productRelated genes to: ZNF185 Blocking Peptide
- Gene:
- ZNF185 NIH gene
- Name:
- zinc finger protein 185 with LIM domain
- Previous symbol:
- -
- Synonyms:
- SCELL
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-12
- Date modifiied:
- 2017-02-28
Related products to: ZNF185 Blocking Peptide
Related articles to: ZNF185 Blocking Peptide
- Cerebro-oculo-nasal syndrome (CONS) is characterized by ocular alterations ranging from anophthalmia/microphthalmia to normal eyes, structural anomalies of the central nervous system, and proboscis-like nares. This syndrome was first described more than 30 years ago, but only 21 patients have been reported to date. - Source: PubMed
Publication date: 2025/11/17
Hazan FilizYılmaz Uzman CerenEmecen Durdugül AyyıldızYılmazer Murat MuhtarÖztürk TaylanBilen Mertkan MustafaHüvez Anılİlhan RecepGenel FerahBallar Petek - Ovarian endometrioma (OMA), an estrogen-dependent gynecological disorder, is characterized by the presence of abundant free iron resulting from recurrent hemorrhage of endometrial cells within the cyst, which adversely affects ovarian function. However, the underlying mechanisms through which iron overload impairs ovarian function remain unclear. In this study, we stimulated KGN cells with ferric ammonium citrate (FAC) in vitro and observed dose-dependent significant alterations, including decreased mitochondrial membrane potential, increased reactive oxygen species (ROS), decreased cell viability, and elevated apoptosis rates. RNA sequencing analysis of iron-overloaded KGN cells demonstrated significant upregulation of ZNF185 expression across multiple concentration gradients and treatment durations. ZNF185 overexpression was found to disrupt F-actin dynamics, triggering a cascade of cellular events including Drp1-mediated mitochondrial hyperfission, endoplasmic reticulum stress, and cytochrome C release, ultimately leading to granulosa cell apoptosis. Importantly, knockdown of ZNF185 was shown to preserve cytoskeletal integrity and attenuate apoptotic responses under conditions of iron overload. Our findings demonstrated that ZNF185 served as a novel iron-responsive regulator involved in iron overload-induced granulosa cell apoptosis. These results might provide potential therapeutic strategies for ovarian fertility preservation in OMA patients. - Source: PubMed
Publication date: 2025/08/28
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