Ask about this productRelated genes to: CYP11B1 Blocking Peptide
- Gene:
- CYP11B1 NIH gene
- Name:
- cytochrome P450 family 11 subfamily B member 1
- Previous symbol:
- CYP11B
- Synonyms:
- P450C11, FHI, CPN1
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: CYP11B1 Blocking Peptide
Related articles to: CYP11B1 Blocking Peptide
- Aldosterone synthase inhibitors (ASIs) demonstrated significant blood pressure (BP) lowering efficacy in patients with uncontrolled hypertension, but evidence in chronic kidney disease (CKD) remains limited. This meta-analysis explores the effects of selective ASIs on BP levels in CKD. Secondary outcomes were albuminuria (UACR), eGFR change and hyperkalemia incidence. Five RCTs (1,148 patients) were included; 2 used baxdrostat, 2 lorundrostat, and 1 study used vicadrostat. Treatment with ASIs was associated with a significant placebo-adjusted reduction in SBP of-7.9 mmHg [95% confidence interval (CI) -10.0 to -5.9, I2 = 0%] and DBP of -3.1 mmHg (95% CI -5.9 to -0.2, I2 = 62%) and reduced UACR by -31.7% (95% CI -54.5 to -8.9, I2 = 91%). The pooled placebo-adjusted eGFR change was -2.05 ml/min/1.73 m2 (95% CI -3.15 to -0.95, I2 = 0%). The risk of hyperkalemia was higher with ASIs, but with high heterogeneity (risk ratio, 4.04 [95% CI 0.94 to 17.35], I2 = 76%). In conclusion, selective ASIs present a potential treatment option for BP control and albuminuria reduction in patients with CKD. - Source: PubMed
Publication date: 2026/07/24
Theodorakopoulou MarietaIatridi FotiniTheodosiadi AikateriniHecking ManfredStrippoli GiovanniSarafidis Pantelis - Many primary aldosteronism (PA) patients harbor concomitant mild autonomous cortisol secretion (MACS), termed "Connshing syndrome." The prevalence and cardiometabolic impact of this co-secretion have not been quantitatively synthesized. - Source: PubMed
Publication date: 2026/07/17
Eisa NaseemKhoury Mira - Complete Androgen Insensitivity Syndrome (CAIS) is a rare X-linked disorder caused by pathogenic variants in the androgen receptor (AR) gene, leading to resistance to androgens in individuals with a 46, XY karyotype. - Source: PubMed
Publication date: 2026/08/03
Misgar Raiz AhmadUl Isam Mir SajadMasoodi Shariq RashidQadir AjazBhat Imtiyaz AhmadShah Zafar AminBashir Mir IftikharWani Arshad Iqbal - Polyendocrine Metabolic Ovarian Syndrome (PMOS) formerly known as Polycystic Ovary Syndrome (PCOS), characterized by hyperandrogenism, affects approximately 7.1-15.1% of women of reproductive age. While disease-causing CYP21A2 and CYP11B1 variants are well-studied, the contribution of synonymous variants to clinical and hormonal variations remains unclear. This study investigated whether synonymous and non-synonymous variants associated with phenotypic heterogeneity. - Source: PubMed
Publication date: 2026/07/31
Polat SeherSimsek Yasin - While high-dimensional flow cytometry plays critical roles in resolving complex cellular networks, there remains a scarcity of comprehensive panels for the simultaneous profiling of diverse mouse cell types, primarily due to the technical challenges of spectral overlap and the limited availability of mouse-validated reagents. To address this technical gap and resolve diverse cell populations in murine models, we designed a 27-color flow cytometry panel optimized for 3-laser spectral flow cytometers. This optimized panel enables broad and simultaneous detection of 16 distinct cell subsets from both lymphoid and myeloid lineages-including T cells, B cells, plasma cells, NK cells, innate lymphoid cells, dendritic cells, monocytes, macrophages, neutrophils, eosinophils, basophils, mast cells-along with non-immune cells, such as epithelial, endothelial, fibroblast, and neuronal-associated cells. The panel has been successfully applied to various tissues, including spleen, thymus, bone marrow, peripheral blood, mesenteric lymph nodes, peritoneal lavage fluid, gut epithelium, and lamina propria. Applying this panel to a poly(I:C) model, we successfully tracked systemic shifts in monocyte and neutrophil populations and identified a previously unrecognized, Cyp11b1-expressing immune cell subset via reporter expression. This panel will facilitate high-dimensional immune profiling on standard 3-laser cytometers, providing a robust tool for dissecting cellular landscapes across diverse contexts. - Source: PubMed
Publication date: 2026/07/20
Song HyeonjiLim YusikLim Jaechul