Ask about this productRelated genes to: CYP11B1 Blocking Peptide
- Gene:
- CYP11B1 NIH gene
- Name:
- cytochrome P450 family 11 subfamily B member 1
- Previous symbol:
- CYP11B
- Synonyms:
- P450C11, FHI, CPN1
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: CYP11B1 Blocking Peptide
Related articles to: CYP11B1 Blocking Peptide
- The adrenal cortex shows sexual dimorphism in structure and function. We analysed adrenal glands from 7-week-old male and female BALB/c mice using Visium HD with Cellpose 3 segmentation, comprising 236,077 cells across eleven populations, including four cortical zones. Using curated marker-gene-based zonal annotation, we focused on steroidogenic enzymes and hormone receptors, complementing our companion study based on the same primary dataset. The X-zone was nearly absent in males but prominent in females. Females showed higher Hsd3b1 expression across cortical zones and higher Cyp11b1 expression in outer cortical compartments. The strongest sex difference involved Srd5a2, with markedly higher expression in male zona fasciculata (inner: 77.1% vs. 28.9%), independently supported by RNAscope and immunohistochemistry. Mc2r and Mrap showed discordant spatial distributions, with limited co-expression, suggesting potential MC2R-independent MRAP roles. Agtr1a dominated angiotensin II receptor expression in zona glomerulosa without major sex differences, providing a zone-resolved reference for adrenal sexual dimorphism. - Source: PubMed
Publication date: 2026/09/04
Blatkiewicz MałgorzataHryhorowicz SzymonSzyszka MartaSuszynska-Zajczyk JoannaOlechnowicz AnnaPorzionato AndreaMalendowicz Ludwik KRucinski Marcin - A six-gene panel involved in androgen production, uptake, and conversion (APUC-6: , , , , , ) may define distinct clinical outcomes in metastatic prostate cancer. This study evaluated the prognostic and predictive value of APUC-6 expression in metastatic castration-sensitive prostate cancer (mCSPC). - Source: PubMed
Publication date: 2026/08/21
Shi XiaoleiShetty Amol CWang JareySong YangSutera Philip ADeek Matthew PPatel Krishnan RMadan Ravi ATang ChadProudfoot JamesDavicioni ElaiHussain ArifNguyen PaulSweeney ChristopherBoytim EllaLacuna Kristine PRyan Charles JAntonarakis Emmanuel STran Phuoc THwang Justin - Primary aldosteronism (PA) is the most prevalent cause of secondary hypertension (HTN), and adrenocorticotropic hormone (ACTH)-independent Cushing's syndrome (CS) represents a distinct form of adrenal-derived secondary HTN. Their coexistence resulting from aldosterone- and cortisol-producing adenomas (A/CPAs) is an extremely rare clinical entity. This is particularly true for the subtype characterized by bilateral adrenocortical adenomas, in which one adenoma predominantly secretes aldosterone (ALD) and the other predominantly secretes cortisol (COR), for which only limited clinical reports have been published to date. - Source: PubMed
Publication date: 2026/08/03
Long RongLi YuGong XinyiWu RunYang QinfeiWang DejunYang YingChen Nan - To study the clinical characteristics, treatment outcomes, and gene mutation spectrum in Uyghur children with 11β-hydroxylase deficiency (11β-OHD) in Xinjiang, and to explore the ethnic-specific features of genotypes and clinical phenotypes. - Source: PubMed
Wang Xiao-YiLuo Yan-FeiChen Yi-RuWei Kai-QiAbulajiang A-Li-YaMaimaiti Mi-Re-Gu-Li - Complete Androgen Insensitivity Syndrome (CAIS) is a rare X-linked disorder caused by pathogenic variants in the androgen receptor (AR) gene, leading to resistance to androgens in individuals with a 46, XY karyotype. - Source: PubMed
Publication date: 2026/08/03
Misgar Raiz AhmadUl Isam Mir SajadMasoodi Shariq RashidQadir AjazBhat Imtiyaz AhmadShah Zafar AminBashir Mir IftikharWani Arshad Iqbal