Ask about this productRelated genes to: SLC26A9 Blocking Peptide
- Gene:
- SLC26A9 NIH gene
- Name:
- solute carrier family 26 member 9
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-25
- Date modifiied:
- 2016-02-17
Related products to: SLC26A9 Blocking Peptide
Related articles to: SLC26A9 Blocking Peptide
- Slc26a9 is a member of the Slc26a family that is highly expressed in the stomach and is a key regulator for maintaining gastric mucosal homeostasis. Slc26a9 deletion in mice impairs the gastric mucosal barrier. However, the role of Slc26a9 in PHG has never been investigated. - Source: PubMed
Publication date: 2026/08/05
Ma ZhiyuanYi ZhiqiangJi BeiHu ChunliLiu ShuhuiZhou ZhengxingZhang MinglinZhu JiaxingWen GuorongJin HaiAn JiaxingTuo BiguangLi TaolangLiu Xuemei - Clinical data show that genetic variants are significant risk factors for acute recurrent pancreatitis and chronic pancreatitis. To expand the understanding of the role of genetics in acute recurrent pancreatitis and chronic pancreatitis, high-throughput next-generation sequencing of 14 genes was completed in a multicenter pediatric cohort. - Source: PubMed
Publication date: 2026/06/16
Abu-El-Haija MaisamZhang WenyingWang FuchenchuCress GretchenDawson BrianSu XiaopingThompson TylerKotha NicoleChugh AnkurCohen Reuven ZevDowns Elissa MFishman Douglas SFreeman A JayGariepy Cheryl EGiefer Matthew JGonska Tanja YGreer PhilGrover Amit SLiman Andrew Y JLindblad DouglasLiu Quin YMaqbool AsimMark Jacob AMcFerron Brian AMehta Megha SMorinville Veronique DNg KennethNoel Robert AOoi Chee YPerito Emily RWilschanski MichaelZheng YuhuaYuan YingWhitcomb David CUc AliyeLowe Mark - Currently, increasing attention is being paid to the role of genes other than and their variants as factors modifying the course of cystic fibrosis (CF). One such gene is , which encodes a protein involved in chloride and bicarbonate transport across the epithelial cell membrane. Variants of , such as c.229G>A (p.Gly77Ser) and c.1885C>T (p.Pro629Ser), have been described in patients with severe and rapidly progressive CF. The aim of this study was to identify variants in a group of 20 patients with CF. DNA was isolated from blood samples and collected from all patients. Fragments of exons 3 and 17 of the gene were amplified by PCR and sequenced using the Sanger method. An SLC26A9 variant was identified in two siblings. These patients were diagnosed with CF in adulthood and presented with moderate pulmonary symptoms without exocrine pancreatic insufficiency. In both siblings carrying the CFTR variants p.Phe508del and c.3140-26A>G, the variant c.1847C>T (p.Pro616Leu) was detected. This variant has not been widely described in the literature and has not previously been associated with CF. The c.1847C>T (p.Pro616Leu) variant is located near a domain that may affect the transport function of the SLC26A9 protein. However, patients in whom the variant was identified did not present a severe disease phenotype. Further studies on larger patient cohorts are required, and at present this variant should be considered of uncertain significance in CF. - Source: PubMed
Publication date: 2026/05/25
Krusiński AdamGrenda AnnaObara AdrianWęgrzyn-Szkutnik IrenaZygmunt WojciechWiniarska HannaKuźnar-Kamińska BarbaraGajek ŁukaszSiwiec JanKrawczyk PawełMilanowski Janusz - Cystic fibrosis related diabetes (CFRD) is relevant for all individuals with cystic fibrosis. Those who are yet to develop the condition require regular screening, and those who have already received a diagnosis need appropriate treatment to limit the potential impact on their clinical condition. CFRD is distinct from type 1 and type 2 diabetes but has overlapping pathophysiology and genetic risk factors. The prevalence of CFRD is expected to increase with an ageing CF population. The impact of highly effective CFTR modulators on CFRD is unknown, but it is possible that sufficiently early treatment could delay or prevent development of CFRD. However, as studies show limited change in incidence and complexity of CFRD in the post modulator era, it is vital to accelerate research that will have direct patient benefit for the growing population of people living with or who will develop CFRD. In this review we highlight three emerging topics presented at the 20th ECFS Basic Science conference: (i) genetic and non-genetic risk factors for CFRD and their potential to inform on CFRD pathophysiology and to improve clinical risk prediction in CFRD, (ii) role of optimising dietary intake and body composition in the clinical management of CFRD, and (iii) applying advances from type 1 diabetes research including stem cells and organ on chip modelling to CFRD. Collectively, these topics outline emerging directions for CFRD research and clinical care. - Source: PubMed
Publication date: 2026/05/19
Snowball JoannaSalem VictoriaWu MalindaBlackman Scott M - Cystic fibrosis-related diabetes (CFRD) is a common metabolic complication in adolescents with cystic fibrosis (CF). Variants in and have been implicated in CFRD susceptibility. The coexistence of CF, CFRD, and celiac disease in childhood is rare and presents diagnostic and therapeutic challenges. We describe a 14-year-old female with CF carrying compound heterozygous mutations (p.Glu831Ter and ). Sweat chloride values were borderline. At age 7, she was diagnosed with celiac disease after elevated anti-tTG IgA (297 U/mL) and IgG (22.6 U/mL) and was started on a gluten-free diet. At age 12 years, she presented with diabetic ketoacidosis and was diagnosed with CFRD, requiring insulin therapy. Genotyping revealed high-risk diabetes and CF-modifier variants: rs7903146 TT () and rs4077468 GG (). This case highlights the interplay of CF, autoimmunity, and genetic predisposition in early onset CFRD. Genetic profiling may improve risk assessment in CF patients with complex endocrine or autoimmune presentations. - Source: PubMed
Publication date: 2026/03/16
Kvaratskhelia EkaAgladze DodoVardosanidze NinoGhughunishvili MariamSurmava SandroAbzianidze EleneTkemaladze Tinatin