Ask about this productRelated genes to: NT5M Blocking Peptide
- Gene:
- NT5M NIH gene
- Name:
- 5',3'-nucleotidase, mitochondrial
- Previous symbol:
- -
- Synonyms:
- dNT-2, dNT2, mdN
- Chromosome:
- 17p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-21
- Date modifiied:
- 2014-11-19
Related products to: NT5M Blocking Peptide
Related articles to: NT5M Blocking Peptide
- Wooden Breast (WB) myopathy is one of the most challenging problems facing the broiler industry. Fibrosis characterized by extracellular matrix (ECM) proteins has been recorded as the prominent pathological feature within the pectoralis major muscles affected by WB. During the process of fibrosis, fibroblasts are the key players. Transforming growth factor-β1 (TGF-β1) serves as the principal cytokine inducing fibroblast to myofibroblast Transition (FMT). The mechanism of TGF-β in regulating fibroblast activation remains unclear despite growing evidence of its involvement. The objective of this study was to establish an in vitro chicken fibroblast activation model using TGF-β1 stimulation, and to explore the transcriptomic changes during this process. Results indicated that TGF-β1 upregulated the expression levels of FMT markers α-SMA, Collagen I, ACTA2, COL1A1, and FN1 in a dose-dependent and time-dependent manner (P < 0.05). Subsequently, RNA-seq analysis showed that a total of 1532 differentially expressed mRNAs (DEmRNAs) were identified between TGF-β1-induced chicken fibroblasts and the control group. We screened crucial biological processes and core DEmRNAs enriched in functional pathways, and established the protein-protein interaction network. Upregulated DEmRNAs including AMPD3, PDE10A and PDE4D, as well as downregulated DEmRNAs including NT5C1B, NT5M, ENTPD1, PDE1A, ADSL, DGUOK and PDE7B were identified as hub genes. Collectively, our current study provides a model framework for investigating the pathogenesis of WB myopathy and advances the mechanistic understanding of TGF-β1-induced fibrosis development in broiler chickens. - Source: PubMed
Publication date: 2025/07/16
Hou TaijiangZhang LinZhao LiangGao FengXing Tong - Pancreatic adenocarcinoma (PAAD) is a highly aggressive and lethal malignancy, characterized by late diagnosis, rapid progression, and poor response to conventional therapies. Altered nucleotide metabolism has recently been recognized as a critical driver of tumorigenesis, impacting cellular proliferation, invasion, and immune evasion. However, the role of specific metabolic enzymes, such as NT5M (cytosolic 5'-nucleotidase, mitochondrial), in PAAD remains poorly understood. In this study, we employed an integrated approach combining comprehensive bioinformatics analysis with systematic in vitro functional assays to investigate the multifaceted roles of NT5M in PAAD. Our investigation focused on three key aspects: (1) establishing NT5M as a novel prognostic biomarker, with lower expression levels significantly correlating with poor clinical outcomes; (2) characterizing the association between NT5M expression and tumor microenvironment (TME) features; and (3) elucidating the mechanistic role of NT5M in immune regulation within PAAD. Importantly, we discovered that NT5M downregulation is associated with increased CXCL8 expression and subsequent PD-L1 upregulation, thereby reversing immune evasion in pancreatic cancer. These findings establish NT5M as both a valuable prognostic indicator for tumor progression and a promising therapeutic target for PAAD. The identification of these interconnected pathways provides a novel strategy for enhancing the efficacy of immune checkpoint blockade therapies, potentially overcoming the current limitations in pancreatic cancer immunotherapy. - Source: PubMed
Publication date: 2025/07/19
Zhai ChaojieYe JiarongZhou ZiyangLuo HongliangLi XiaoyanLiu JipengZhou XinchiWang ZuaoZhang XuZeng WenChen LeifengZhou Fan - Prolonged natural selection and artificial breeding have contributed to increased uniformity within the Tibetan sheep population, resulting in a reduction in genetic diversity and the establishment of selective signatures in the genome. This process has led to a loss of heterozygosity in specific genomic regions and the formation of Runs of Homozygosity (ROH). Current research on ROH predominantly focuses on inbreeding and the signals of selection; however, there is a paucity of investigation into the genetic load and selective pressures associated with ROH, both within these regions and beyond. On one hand, genes located situated ROH hotspot regions exhibit a degree of conservation in their genomic segments; on the other hand, these regions may also serve as critical loci for identifying signals of selection. - Source: PubMed
Publication date: 2025/01/22
Sun LixiaYuan ChaoGuo TingtingBai YaqinLu ZengkuiLiu Jianbin - Dysfunction of the immune system and inflammation plays a vital role in developing intracranial aneurysms (IAs). However, the progress of genetic pathophysiology is complicated and not entirely elaborated. This study aimed to explore the genetic associations of immune-related and inflammation-related genes (IIRGs) with IAs and their subtypes using Mendelian randomization, colocalization test, and integrated multiomics functional analysis. - Source: PubMed
Publication date: 2025/01/01
Lin Peng-WeiLin Zhen-RongWang Wei-WeiGuo Ai-ShunChen Yu-Xiang - L. (RC) is a classic herbal medicine for the treatment of rheumatoid arthritis (RA) and has been used since ancient times. The ethanol extract of L. (RCE) showed obvious anti-RA effects in our previous study. However, further potential mechanisms require more exploration. We aimed to investigate the mechanism of RCE for the treatment of RA by integrating metabolomics and network pharmacology in this study. - Source: PubMed
Publication date: 2023/02/11
Zeng WeiyaFang YuanMo SuifenShen CaihongYang HuilingLuo GuihuaXiao LuhuaZhan RuotingYan Ping