Ask about this productRelated genes to: Uap1l1 Blocking Peptide
- Gene:
- UAP1L1 NIH gene
- Name:
- UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-01-29
- Date modifiied:
- 2018-11-22
Related products to: Uap1l1 Blocking Peptide
Related articles to: Uap1l1 Blocking Peptide
- Numerous factors, including genetic, environmental, and nutritional, are involved in testicular development and spermatogenesis. However, little is known about the effects of seasonal factors on pre-sexual maturity testicular development in Hu rams, which are famous for their high fertility and year-round estrus onset. This study explored the effect of the birth season on testicular development and spermatogenesis in Hu sheep. Thirty-six 6-month-old male lambs born in summer (n = 18) and winter (n = 18) were selected for analysis. Results showed that summer-born lambs exhibited significantly higher cauda sperm density (102.65 ± 9.56 vs. 16.86 ± 2.02 × 10/g), antioxidant indices such as superoxide dismutase (SOD: 6.29 ± 1.01 vs. 4.09 ± 0.25 U/mgprot), and higher expression levels of glutathione peroxidase 3 (), glutathione peroxidase 4 (), and copper/zinc superoxide dismutase (/) than winter-born lambs. Conversely, the malondialdehyde content (1.08 ± 0.32 vs. 2.13 ± 0.34 nmol/mgprot) was significantly lower in the summer-born group ( < 0.05) than in the winter-born group. A total of 44 differential oxylipins and 326 differentially expressed genes (DEGs) were screened by ultra-performance liquid chromatography-tandem mass spectrometry and transcriptomics, respectively. An integrated analysis of oxylipins and transcriptomics revealed that these differential molecules were enriched in metabolic pathways. Notably, downregulated DEGs (e.g., UAP1L1 and NAT8L) were significantly correlated with upregulated differential oxylipins (e.g., epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids). These results indicate that compared to the winter-born group, the testicular tissues of summer-born rams showed stronger testicular antioxidant capacity and lower lipid peroxidation at the sexual maturity stage, which contributes to spermatogenesis. - Source: PubMed
Publication date: 2025/09/27
Li WanhongZhang XinyueShen JieWeng Xiuxiu - Dietary intake and metabolism variations are associated with molecular changes and more particularly in the transcriptome. O-GlcNAcylation is a post-translational modification added and removed respectively by OGT and OGA. The UDP-GlcNAc, the substrate of OGT, is produced by UAP1 and UAP1L1. O-GlcNAcylation is qualified as a metabolic sensor and is involved in the modulation of gene expression. We wanted to unveil if O-GlcNAcylation is linking metabolic transition to transcriptomic changes and to highlight modifications of O-GlcNAcylation during the postnatal cardiac development. - Source: PubMed
Publication date: 2024/04/30
Persello AntoineDupas ThomasVergnaud AmandineBlangy-Letheule AngéliqueAillerie VirginieErraud AngéliqueGuilloux YannickDenis ManonLauzier Benjamin - In this study, to screen for candidate markers of temozolomide (TMZ) resistance in glioblastoma, we artificially established TMZ drug-resistant glioblastoma (GBM) cell lines, U251-TMZ and U87-TMZ. In the U251-TMZ and U87-TMZ cell lines, we screened and analyzed differentially expressed proteins using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) differential proteomics. Compared with the U251 and U87 control cell lines, 95 differential proteins were screened in the U251-TMZ and U87-TMZ cell lines, of which 28 proteins were upregulated and 67 proteins were down-regulated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of the co-upregulated proteins showed that most of the differentially expressed proteins were located in the cytoplasm and were significantly upregulated in the biological processes related to vesicular transport in the intimal system and inflammatory response mediated by myeloid leukocytes. Seven candidates were identified as potential GBM markers of TMZ resistance. Combined with existing research findings, our study supports that UAP1L1 and BCKDK are promising potential markers of TMZ resistance in GBM. This is important for further understanding the molecular mechanisms that drive the development and enhancement of TMZ resistance. - Source: PubMed
Publication date: 2023/12/01
Li DaYan JunLi KangYang QingchengBian LipingLin BenchengLiu XiaohuaXi Zhuge - Prostate cancer is the second most common cancer in men, and some new target genes are needed to predict the risk of prostate cancer progression and the treatment. - Source: PubMed
Publication date: 2022/02/15
Wu Xing-ChengYu Yu-ZhongZuo Yu-ZhiSong Xian-LuZhou Zhi-EnXiao YuLuo Dao-ShengYan Wei-GangZhao Shan-Chao - Uridine diphosphate--acetylglucosamine pyrophosphorylase-1-like-1 () is involved in protein glycosylation and promotes proliferation in some tumors. By analyzing the publicly available Gene Expression Omnibus (GEO) database, we found that displayed a significant change between paired glioma and normal brain tissues. The purpose of this study was to investigate the expression and functional role of in glioma. - Source: PubMed
Yang ZhuanyiYang ZhiquanHu ZhongliangLi BoLiu DingyangChen XiaoyuWang YingFeng Deyun