Ask about this productRelated genes to: Scara3 Blocking Peptide
- Gene:
- SCARA3 NIH gene
- Name:
- scavenger receptor class A member 3
- Previous symbol:
- -
- Synonyms:
- CSR1, CSR, MSLR1, APC7, MSRL1
- Chromosome:
- 8p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-09-06
- Date modifiied:
- 2016-10-05
Related products to: Scara3 Blocking Peptide
Related articles to: Scara3 Blocking Peptide
- Animals with seasonal reproductive cycles, as the Roe deer (Capreolus capreolus), have developed mechanisms to synchronize reproduction with the environmental cycle in order to optimize reproductive success through melatonin. Angiogenesis and oxidative stress are key processes in spermatogenesis, contributing to testicular remodeling and recovery after reproductive effort. This study carried out a gene expression analysis on 18 samples of mature male Roe deer testicles, collected during the local hunting season in pre-rut (N = 9) and post-rut (N = 9) periods. A quantitative real-time PCR (qPCR) array targeting 84 genes involved in oxidative stress and 84 in angiogenesis were used, followed by validation through individual qPCR of selected genes and related protein quantification by ELISA assays. Post-rut animals showed upregulation of several antioxidant genes: Peroxiredoxin-4 (PRDX4), Scavenger receptors class A member 3 (SCARA3), Superoxide Dismutase 3 (SOD3). Instead, Leptin (LEP) and Thrombospondin Ⅱ (THBSⅡ), a known angiogenesis inhibitor, are downregulated. A novel insight is represented by the upregulation of Neuropilin (NRP2) in post-rut period that, given to its posttranscriptional silencing too, needs better investigations. The pleiotropic nature of NRP2, including roles in neurodevelopment, immune modulation, and vascular remodeling, makes this gene an interesting candidate for further study, cause its function in reproductive tissues remains poorly understood. - Source: PubMed
Publication date: 2026/01/27
Troisio IlariaVentrella DomenicoHausz Bálint LórántCesauri MattiaVannetti Niccolò IanBacci Maria LauraElmi AlbertoZannoni Augusta - Caprine arthritis and encephalitis (CAE), caused by small ruminant lentivirus (SRLV), is a key disease of goats, with chronic inflammation of joints and brain symptoms leading to losses in milk production and animal trade. In this study, we analyzed gene expressions in the milk somatic cells (MSCs) of seropositive (SRLV-SP) and seronegative (SRLV-SN) goats to identify transcriptomic changes using a non-invasive sampling method. - Source: PubMed
Publication date: 2025/07/03
Pławińska-Czarnak JoannaMajewska AlicjaZarzyńska Joanna MagdalenaKaba JarosławBagnicka Emilia - Class A scavenger receptor 3 (SCARA3), a macrophage scavenger receptor-like protein, plays important roles in inhibiting cell proliferation, migration, and invasion. In the present study, a SCARA3 gene of turbot (SmSCARA3) (Gene ID: 118289953) with an 1815 bp ORF encoding 604 amino acids was identified. Phylogenetic analysis revealed that SmSCARA3 showed the closest relationship to that counterpart of olive flounder (Paralichthys olivaceus). The synteny analysis demonstrated conserved syntenic patterns across selected vertebrates. In addition, SmSCARA3 was ubiquitously expressed in all the examined tissues, with the highest expression level in intestine and the lowest expression level in the brain. SmSCARA3 exhibited different expression patterns in mucosal tissues (intestine, gill, skin) after two bacterial infections. Subsequently, recombinant SmSCARA3 protein (rSmSCARA3) revealed the strong binding affinity to LPS and responded primarily to LPS stimulation in intestinal cells of turbot. Additionally, the interference and overexpression experiments indicated that SmSCARA3 was associated with apoptosis related genes, such as Caspase1, Caspase3 and Caspase3a, and it could activate Caspase3 in HEPG2 cells. Moreover, flow cytometry revealed the apoptosis of SmSCARA3 overexpression group increased by 10.03%, which was consistent with the effect of SmSCARA3 on proliferation inhibition in intestinal cells of turbot. The cell apoptosis levels in the SmSCARA3-Flag and XIAP-HA experimental group were significantly lower than that in the control group (51.17% vs 72.72%). Finally, the Co-IP assay showed that SmSCARA3 could directly interact with XIAP. In conclusion, our results indicated that SmSCARA3 could activate Caspase3 and modulate apoptosis through XIAP , highlighting its potential roles as a therapeutic target for fish diseases. - Source: PubMed
Publication date: 2025/04/05
Zhuang XinghuaChen XuanCao LiliWang BeibeiWang ZhongyiLi SuwanLi HonghongLi ChaoYang Ning - The safety of titanium dioxide (TiO), widely used in foods and personal care products, has been of ongoing concern. Significant toxicity of TiO has been reported, suggesting a risk to human health. To evaluate its potential epigenotoxicity, the effect of exposure to a TiO product to which humans could be exposed on DNA methylation, a primary epigenetic mechanism, was investigated using two human cell lines (Caco-2 (colorectal) and HepG2 (liver)) relevant to human exposure. Global methylation was determined by enzyme-linked immunosorbent assay-based immunochemical analysis. Gene promoter methylation was evaluated using EpiTect Methyl II Signature PCR System Array technology. Expression of DNA methyltransferases, , and was quantified by qRT-PCR. A decrease in global DNA methylation was observed in both cell lines. Across the cell lines, seven genes (, , , , , , and ) were identified in which promoters were methylated. Changes in promoter methylation were associated with gene expression. Results also revealed aberrant expression of regulatory genes, DNA methyltransferases, MBD2, and UHRF1. Findings from the study clearly demonstrate the impact of TiO exposure on DNA methylation in two cell types, supporting the potential involvement of this epigenetic mechanism in its biological responses. Hence, epigenetic studies are critical for complete assessment of potential risk from exposure. - Source: PubMed
Publication date: 2024/12/19
Wells CarlosPogribna MartaSharmah ArjunParedes AngelWord BeverlyPatri Anil KLyn-Cook BeverlyHammons George - Cervical cancer is the fourth most common cancer among women globally. The detrimental health effects of estrogenic endocrine disruptors (EED), such as bisphenol A (BPA) and phthalates, are recognized, but their role in cervical cancer progression remains unclear. To investigate this, a transcriptome analysis using bioinformatics was conducted. The Comparative Toxicogenomics Database (CTD) identified estrogen-responsive genes (ERGs) associated with EED. Cervical cancer expression and clinical data were sourced from The Cancer Genome Atlas (TCGA). The limma package identified differentially expressed ERGs (DERGs), which were further analyzed for molecular mechanisms through enrichment analysis. LASSO regression developed a prognostic risk score model, and COX analysis identified prognostic biomarkers. ssGSEA assessed immune tumor infiltration, and Autodock performed molecular docking. A total of 217 DERGs were linked to endocrine resistance, estrogen signaling, and the cell cycle. The prognostic risk score and nomogram based on DERGs were highly predictive of cervical cancer prognosis and could serve as independent risk factors. The risk score influenced the tumor immune microenvironment by affecting immune cell presence. SCARA3 and FASN emerged as independent prognostic factors, with molecular docking confirming strong binding between EED and FASN. DERGs can aid in creating a reliable prognostic model and predicting overall survival in cervical cancer patients, offering new insights into the impact of EED on cancer progression and highlighting environmental factors related to cancer risks and development. - Source: PubMed
Publication date: 2024/09/19
Xi YanniZheng PengshengXi WenjinFu Ting