Ask about this productRelated genes to: JAKMIP2 Blocking Peptide
- Gene:
- JAKMIP2 NIH gene
- Name:
- janus kinase and microtubule interacting protein 2
- Previous symbol:
- -
- Synonyms:
- JAMIP2, KIAA0555
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 2006-02-23
- Date modifiied:
- 2014-11-19
Related products to: JAKMIP2 Blocking Peptide
Related articles to: JAKMIP2 Blocking Peptide
- Uterine diseases in dairy cattle are associated with reduced fertility, but the specific mechanisms of disease-mediated subfertility are not known. We hypothesized that intrauterine infusion of Escherichia coli and Trueperella pyogenes would alter the endometrial transcriptome and compromise oocyte developmental competence after disease resolution. Non-lactating Holstein cows received an intrauterine infusion of either sterile phosphate-buffered saline (n = 29) or pathogenic E. coli and T. pyogenes (n = 32) on day 3 of the estrous cycle to induce acute endometrial inflammation. Oocytes of antral follicles were collected by ovum pick-up following estrous synchronization 23 days after intrauterine infusion and underwent in vitro embryo production. Endometrial samples were collected on day 16 of the estrous cycle via cytobrush 41 days after infusion and analyzed by RNA sequencing. Bacterial infusion had no effect on oocyte development to the blastocyst stage, but increased blastocyst expression of CDK7, CHSY1, and LSM4 and tended to reduce the molecular signature of embryo competence for survival. Bacterial infusion altered the expression of 203 genes in the endometrium 41 days after infusion, increasing expression of GSTA3, PVALB, JAKMIP2, FOLH1B, and TCF23, and decreasing expression of MYMK, LOC104974498, CDRT1, KIAA0408, and SLC45A2. Differentially expressed genes were annotated to 54 canonical pathways, with glutathione-mediated detoxification being the top predicted pathway activated following bacterial infusion. Collectively, this work demonstrates that bacterial infections can have lasting effects on the uterus and potentially reduce the molecular competence of oocytes, providing a link to the long-term subfertility of cows after uterine disease. - Source: PubMed
Seekford Zachary KTariq ArslanHaimon McKenzie L JHoorn Quinn AMacay Gabriela AZhai YutingBlock JeremyRabaglino Maria BelenJeong Kwangcheol CHansen Peter JBromfield John J - Microtubules are present in all eukaryotes, and their spatial organization in the cells depends on the function of microtubule-organizing centers (MTOCs). Various organelles may act in this capacity, including the centrosome, Golgi, nuclear envelope, endosomes, and others. The molecular mechanisms that facilitate microtubule nucleation and/or anchoring at MTOCs are diverse. Many proteins can participate in these processes while localized to different MTOCs-either simultaneously on several or alternately on each of them. Here we studied the Golgi-associated protein JAKMIP2 in various cells using the methods of fluorescent multichannel confocal microscopy with subsequent image analysis via our own algorithm, transfection with a genetic construct encoding a fused protein of interest, and microtubule recovery monitoring during nocodazole washout. We demonstrated for the first time that JAKMIP2 is present on centrosomes in various cells. We also found that its abundance at this location is dependent on the cell cycle stage. Furthermore, we showed that an excess of JAKMIP2 specifically impairs centrosome function as a MTOC. Finally, our data indicates that exogenous JAKMIP2 slows down centrosomal microtubule nucleation and may also affect their anchoring. Our findings make a new contribution to the existing knowledge of the molecular mechanisms of the centrosome's function as a MTOC. - Source: PubMed
Publication date: 2025/12/18
Ulas EvgeniiaBrodsky IlyaPadaryan PetrosBurakov Anton - The human genome contains approximately 3,200 near full-length autonomous human endogenous retroviral (HERV) genomes distributed across the 23 chromosomes. These autonomous HERV proviral genomes include long terminal repeats (LTRs) capable of promoting RNA transcription. In quiescent cells, most HERV loci remain transcriptionally silent. However, environmental changes, such as epigenetic remodeling of chromatin, can activate these silenced loci. - Source: PubMed
Publication date: 2025/06/26
Koo HyunminMorrow Casey D - The Awarik camel population in southwestern Saudi Arabia exhibits unique genetic and phenotypic traits compared to other domestic camel populations. This study aims to explore the genomic signatures of positive selection in Awarik camels to understand their evolutionary history and identify genetic adaptations potentially shared with East African camel populations. - Source: PubMed
Publication date: 2024/09/18
Almathen Faisal - About 70% of advanced-stage prostate cancer (PCa) patients will experience bone metastasis, which severely affects patients' quality of life and progresses to lethal PCa in most cases. Hence, understanding the molecular heterogeneity of PCa cell populations and the signaling pathways associated with bone tropism is crucial. For this purpose, we generated an animal model with high penetrance to metastasize to bone using an intracardiac percutaneous injection of PC3 cells to identify PCa metastasis-promoting factors. Using genomic high-throughput analysis we identified a miRNA signature involved in bone metastasis that also presents potential as a biomarker of PCa progression in human samples. In particular, the downregulation of miR-135b favored the incidence of bone metastases by significantly increasing PCa cells' migratory capacity. Moreover, the , , , and target genes were identified as potential mediators of miR-135b's role in the dissemination to bone. In this study, we provide a genomic signature involved in PCa bone growth, contributing to a better understanding of the mechanisms responsible for this process. In the future, our results could ultimately translate into promising new therapeutic targets for the treatment of lethal PCa. - Source: PubMed
Publication date: 2021/12/09
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