Ask about this productRelated genes to: PNMA1 Blocking Peptide
- Gene:
- PNMA1 NIH gene
- Name:
- PNMA family member 1
- Previous symbol:
- -
- Synonyms:
- MA1
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-17
- Date modifiied:
- 2017-09-15
Related products to: PNMA1 Blocking Peptide
Related articles to: PNMA1 Blocking Peptide
- The interplay between crystal symmetry and strain provides a powerful, yet underexplored, route for tailoring the optoelectronic properties of lead-free KSnI perovskites. In the present work, a comprehensive structure-property-strain framework is established through systematic first-principles analysis, revealing how symmetry and mechanical deformation govern the electronic structure and optical response across multiple polymorphs. Only the orthorhombic ( and ) and monoclinic ( /) phases are found to be dynamically, thermally, and mechanically stable, whereas the tetragonal ( and ) phases exhibit lattice instabilities. Electronically, and / exhibit indirect semiconducting behavior, while , , and possess direct band gaps, enabling a symmetry-driven optoelectronic functionality. All stable phases exhibit strong polarization-dependent visible-UV absorption with extending into the infrared, yielding a broadband optical response. Notably, the / phase is distinguished by a y-polarized absorption coefficient of 1.06 × 10 cm at 1.88 eV and a reflectivity of up to 82%, highlighting its potential for high-performance optical coating applications. Going beyond static properties, biaxial and triaxial strain emerge as efficient routes for tuning the band gap and optical response of KSnI phases over a wide energy range. Overall, our findings demonstrate KSnI as a highly tunable lead-free perovskite platform where symmetry and strain serve as key design parameters for optoelectronic applications. - Source: PubMed
Publication date: 2026/05/02
Ayvalik AynurDogan Kadir CanCetin ZebihYagmurcukardes MehmetOrucu Humeyra - Retinoblastoma (RB) is the most common malignant eye tumor in children. Cytotoxic drugs like melphalam often cause significant side effects and acquired resistance in RB treatment. Here, the impact of Paraneoplastic Ma1 (PNMA1) on RB progression and chemotherapy resistance was investigated. A series of bioinformatics methods were used for differential expression genes and drug resistance genes screening. Western blot was performed for the detection of genes expression. CCK-8 and EdU staining were assessed for cell viability. Clone formation and TUNEL staining were examined for cell viability and apoptosis. Wound healing and transwell assays were analyzed for the cell migrated and invasive abilities. Immunofluorescence was observed for γ-H2AX expression. Colorimetric PARP/Apoptosis Assay was used for PARP activity. PNMA1 was upregulated in RB tumor tissues, and high expression of PNMA1 promotes RB cells' chemoresistance to melphalam, while downregulation of PNMA1 reversed chemoresistance in resistant cells. Furthermore, the mechanism by which PNMA1 mediated chemoresistance to melphalam, discovered that PNMA1 might facilitate melphalam resistance through the c-myc-mediated DNA damage repair pathway. PNMA1 functions as a tumor-promoting factor in retinoblastoma and may regulate melphalam resistance through the upregulation of the c-myc gene and the involvement in DNA damage repair. - Source: PubMed
Publication date: 2025/07/23
Sun LonggeXu ZhaokangZhang XinDu XingLi GuanghuiGuo Yuanyuan - Almost half of the human genome consists of retrotransposons-'parasitic' sequences that insert themselves into the host genome via an RNA intermediate. Although most of these sequences are silenced or mutationally deactivated, they can present opportunities for evolutionary innovation: mutation of a deteriorating retrotransposon can result in a gene that provides a selective advantage to the host in a process termed 'domestication'. The PNMA family of gag-like capsid genes was domesticated from an ancient vertebrate retrotransposon of the Metaviridae clade at least 100 million years ago. PNMA1 and PNMA4 are positively regulated by the master germ cell transcription factors MYBL1 and STRA8, and their transcripts are bound by the translational regulator DAZL during gametogenesis. This developmental regulation of PNMA1 and PNMA4 expression in gonadal tissue suggested to us that they might serve a reproductive function. Through the analysis of donated human ovaries, genome-wide association studies (GWASs) and mouse models, we found that PNMA1 and PNMA4 are necessary for the maintenance of a normal reproductive lifespan. These proteins self-assemble into capsid-like structures that exit human cells, and we observed large PNMA4 particles in mouse male gonadal tissue that contain RNA and are consistent with capsid formation. - Source: PubMed
Publication date: 2025/04/22
Wood Thomas W PHenriques William SCullen Harrison BRomero MayraBlengini Cecilia SSarathy ShreyaSorkin JuliaBekele HilinaJin ChenKim SeungsooWang XifanLaureau RaphaelleChemiakine AlexeiKhondker Rishad CIsola José V VStout Michael BGennarino Vincenzo AMogessie BinyamJain DevanshiSchindler KarenSuh YousinWiedenheft BlakeBerchowitz Luke E - Diabetic foot ulcers (DFUs), a severe and common complication of diabetes, present significant treatment challenges due to the limitations of conventional dressings, such as poor mechanical properties, bioactivity, and limited functionality, which hinder fast and effective wound healing. To address these issues, we developed a novel natural amino acid-based hydrogel loaded with paeoniflorin (PF@PNMA1) and comprehensively evaluated its properties and functions. The nanogel particles (NGs) were synthesized via emulsion polymerization using N-isopropylacrylamide (NIPAM), methacrylic acid (MAA), and chemically modified arginine (MArg). The poly(NIPAM-co-MAA) (PNM) and poly(NIPAM-co-MAA-co-MArg) (PNMA) gels were prepared by functionalizing the NGs with glycidyl methacrylate (GMA). The different concentrations of amino acids were added to explore the optimal mechanical properties of the gel. Through the rheological measurement, we found that PNMA1 gel has good ductile properties with a critical strain up to about 63 %. At the same time, we also verified its antibacterial activity and found that the viability of bacteria decreased to 47.46 % after 3 h. Preliminary tests using network pharmacology and molecular docking confirmed the therapeutic potential of PF for DFUs. The PF@PNMA1 gel demonstrated excellent biocompatibility, and in vivo experiments revealed its effectiveness in promoting angiogenesis and wound healing. After 10 days, the wound healing rate was 25.6 % higher than that of the control group. The PF@PNMA1 shows great potential as an effective therapy for DFUs treatment. - Source: PubMed
Publication date: 2025/04/05
Jia XintaoDou ZixuanZhang YingYu ChangxiangYang MengruXie HaonanLin YunLiu Zhidong - Epilepsy affects 1-2% of the world population, is enigmatic in 30% of cases, and is often intractable, unresponsive to antiepileptic drugs, and accompanied by cognitive, psychiatric and behavioral problems. Tests for Autoimmune Epilepsy are not performed routinely, and limited to passive diagnosis of known autoimmune antibodies, without essential functional tests to reveal active pathogenic antibodies. We investigated two young Epilepsy patients with different Epilepsy characteristics, repeated intractable seizures, and enigmatic etiology. We suspected Autoimmune Epilepsy. We found that both patients have elevated IgG antibodies, and three types of glutamate receptor antibodies, to: AMPA-GluR3B, NMDA-NR1 and NMDA-NR2 peptides. In contrast, they lack autoantibodies to: LGI1, CASPR2, GABA-RB1, Amphiphysin, CV2, PNMA1, Ri, Yo, Hu, Recoverin, Soxi and Titin. IgG antibodies of both patients bound and killed human neural cells In vitro. Moreover, In vivo video EEG studies in naive rats revealed that patient's IgG antibodies, infused continually into rat brain, bound neural cells in the hippocampus and cortex, caused neural loss in these brain regions, and induced recurrent Generalized Tonic Clonic Seizures. We assume they can do so also in the patient's brain. This is the first model of human Autoimmune Epilepsy in rats. It can serve for discovery of patient's pathogenic antibodies, and drug development. Tests for autoimmune antibodies that bind glutamate receptor peptides, and functional diagnostic tests, are obligatory in all enigmatic intractable Epilepsy patients. Current diagnosis of Autoimmune Epilepsy is insufficient! If pathogenic antibodies are found, intractable patients must receive available, suitable and potentially life-changing immunotherapies for Autoimmune Epilepsy. - Source: PubMed
Publication date: 2025/02/11
Taiwo Rhoda OloweGoldberg Hadassa StermIlouz NiliSingh Prince KumarShekh-Ahmad TawfeeqLevite Mia