AGXT2L1 Blocking Peptide
- Known as:
- AGXT2L1 Blocking Peptide
- Catalog number:
- 33r-4639
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- AGXT2L1 Blocking Peptide
Related genes to: AGXT2L1 Blocking Peptide
- Gene:
- ETNPPL NIH gene
- Name:
- ethanolamine-phosphate phospho-lyase
- Previous symbol:
- AGXT2L1
- Synonyms:
- -
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 2001-01-19
- Date modifiied:
- 2014-11-19
Related products to: AGXT2L1 Blocking Peptide
Related articles to: AGXT2L1 Blocking Peptide
- Obesity is closely linked to the development of non-alcoholic fatty liver disease (NAFLD), yet its mechanisms are not fully understood. Ethanolamine phosphate phospholyase (ETNPPL), an enzyme highly expressed in the liver, catalyzes the conversion of phosphoethanolamine to ammonia, inorganic phosphate, and acetaldehyde. This study shows that ETNPPL plays a crucial role in obesity-associated NAFLD by regulating lipid accumulation, liver dysfunction, and lipid homeostasis. ETNPPL expression was increased in high-fat diet (HFD)-induced NAFLD mice, while its deficiency alleviated NAFLD. ETNPPL overexpression and free fatty acids (FFAs) exposure promoted ferroptosis in hepatocytes. The FFAs-ETNPPL signaling axis induces lipid accumulation and dysfunction through ferroptosis via the GPX4/mtROS pathway and the inhibition of ALDH2. Moreover, FFAs-induced hepatocyte ferroptosis reprogrammed macrophages, exacerbating liver dysfunction. In vivo, ETNPPL knockout reduced hepatic ferroptosis and macrophage reprogramming in mice. These findings highlight ETNPPL as a potential therapeutic target for obesity-related NAFLD. - Source: PubMed
Publication date: 2026/03/25
Gui RunlinLi YangZhang LiyaoJin JunchangShi YuqiWang JunxuanGuo JingyuQian LuXiong Yuyan - Microplastics are emerging contaminants that pose health risks. They can cause hepatic lipid interventions, but the underlying mechanisms require investigation. This study assessed the retention of polypropylene microplastics in mouse liver and determined the intercorrelations between hepatic lipid fluctuations and transcriptomic changes. Microplastic-induced liver dysfunction was confirmed by the variations of transamination, cholesterol metabolism, biotransformation, and redox state. Chronic high-dose treatment induced distinct pathological changes, including regional fibrotic remodeling and ultrastructural mitochondrial abnormalities. Raman biospectra of liver slice proposed vital peaks of 1060, 1132, 1168, 1340, 1446, 1618, and 1670 cm, representing the liver biomolecule landscapes. Transcriptomic changes were mainly involved in mRNA transcription, multicellular organism development, various stimuli response, cell differentiation, and lipid metabolic process. Microplastic exposure dosage exerted more profound effects than exposure duration on gene expressions of oxidation-reduction process, signal transduction, and lipid metabolism. WGCNA analysis proposed 47 hub genes involved gene expression orchestration, cell fate monitor, and mitochondria translation modulation. Nine differentially expressed genes associated with lipid biomarkers were related to mitochondria transcription ( and ), cell differentiation , and ), lipid catabolism ( and ) and tRNA methyltransferase (), and Raman peak at 1670 cm intimately connected with aggregated forms of protein. Our findings suggested that polypropylene microplastics could change the liver molecular landscape and induce lipid metabolism disorders and transcriptomic changes in mitochondrial protein translation and expression regulation, highlighting their significant consequences in nutrient and energy imbalance. - Source: PubMed
Publication date: 2025/10/29
Wang MiaoWang JingSun XinglinZhang KenaGao JingXu XiaoyingWu JiaruiTao FangfangZhang DayiLiu Mingying - Yulin black duck with an all black body, is a native duck breed from Guangxi Province, China, and people like to use the duck to make soup because its meat is considered as a nutritious food and medicinal herb. At present, the molecular mechanisms related to its meat characteristics are still unclear. Furthermore, the differences in muscle development between Yulin black duck and Pekin duck need to be thoroughly investigated. This study aims to elucidate the disparities in muscle development between the two duck breeds and provide foundational data to enhance our understanding of the meat production mechanisms in Yulin black duck. In this study, three embryonic developmental stages (E15, E21 and E27) of Pekin duck and Yulin black duck were selected to investigate muscle development. Integrated transcriptomics and metabolomics were jointly analyzed to compare the significantly different metabolites (SDMs) and differentially expressed genes (DEGs) associated with muscle development between the two duck breeds at identical embryonic stages. The RNA-seq results were further validated using qRT-PCR. The results revealed a total of 106 DEGs in BME 15 vs. PME 15 (BM: the muscle of Yulin black duck, PM: the muscle of Pekin duck), with 57 genes up-regulated and 49 genes down-regulated. A total of 135 DEGs were identified in BME 21 vs. PME 21, including 74 up-regulated and 84 down-regulated genes. In BME 27 vs. PME 27, 65 DEGs were up-regulated, and 70 were down-regulated. As important DEGs about muscle development, CLDN18, PRKAR2B, PHGDH, GPT2, ASL, WIF1, CHRM5, NTNG1, and LOC101804261 were identified. Significant metabolic pathways included the Wnt signaling pathway (apla04310), regulation of the actin cytoskeleton (apla04810), biosynthesis of amino acids (apla01230), cell adhesion molecules (apla04514), and the insulin signaling pathway (apla04910). Meanwhile, 68, 80, and 69 differential metabolites were identified at three embryonic development stages (E15, E21, and E27), primarily involving the glycerophospholipid category: PE(22:4/0:0), PE(P-16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), PE(15:0/0:0), and PG 38:5. Combined analysis demonstrated that ETNPPL exhibited a negative correlation with the expression of differential metabolites such as PG and PI in the glycerophospholipid metabolism pathway. In contrast, HDC and acetylhistamine showed a positive correlation in the histidine metabolism pathway. Additionally, GAD1, which was involved in the alanine, aspartate, and glutamate metabolism pathway, displayed a negative correlation with specific metabolites. In conclusions, CLDN18, PRKAR2B, PHGDH, GPT2, ASL, WIF1, CHRM5, NTNG1, and LOC101804261 were important DEGs in the breast muscles of the Pekin duck and Yulin black duck at the same period of the embryonic stage, and the SDMs of the two duck species were mainly glycerophospholipids. Significant metabolic pathways included the Wnt signaling pathway, regulation of the actin cytoskeleton, biosynthesis of amino acids, cell adhesion molecules, and the insulin signaling pathway. These results will provide effective information and more evidence for further exploring the regulatory mechanisms of skeletal muscle development in duck breeds. - Source: PubMed
Publication date: 2026/01/14
Hu ZhigangCai YingjieZhi ZhuoCui MengmengZhang HuiyaZhou JieZhang JianqinLiu Xiaolin - The dysregulation of phosphatidylcholine (PC), triglycerides (TG), phosphatidylethanolamine (PE), and cardiolipin (CL) metabolism is believed to contribute to the development of MASLD. However, little is known about the mechanisms underlying the onset of this condition. To establish a mouse model of MASLD, C57BL/6J mice were fed a high-fat diet (HFD). Lipidomics was applied to identify differences in liver lipids. RNA-sequencing and bioinformatics analyses were conducted to investigate changes in the expression of genes and pathways associated with these metabolic processes. 49 lipid classes and 3221 lipid species were identified using positive- and negative-ion pattern identification. A total of 678 differentially expressed genes were identified, of which 364 were upregulated and 314 were downregulated in the MASLD group. KEGG enrichment pathway analysis highlighted the downregulation of four genes such as Gpat4, Gpcpd1, Chkb, and Etnppl. These findings contribute to our understanding of the metabolic changes associated with MASLD. - Source: PubMed
Publication date: 2025/11/07
Liang HongSong Kang - Iron plays a key role in oxygen transport, hematopoiesis, and hypoxia adaptation. This study aimed to explore the dynamic response mechanism of the iron regulatory network and key genes in Duroc piglets. Eighteen weaned piglets were randomly divided into three dietary intervention groups: low iron (0 mg/kg), conventional (100 mg/kg), and high iron (200 mg/kg). Transcriptomics technology was used to screen key liver iron regulatory genes under the influence of different dietary iron concentrations, and the expression of related genes was verified using primary pig liver cells. Fasting serum iron metabolism parameters were detected and iron content in organs was quantified. The results show, enrichment analysis highlighted immune-metabolic signaling, including , , and , and a total of 14 candidate genes (such as , , , , ) were identified. The study observed that these genes showed obvious dosage differentiation and nonlinear patterns. However, findings reflect mRNA-level changes and GO/KEGG over-representation, protein-level validation is planned in follow-up studies. Through the integration of in vitro and in vivo data, this study discovered new liver genes that may be related to pig iron homeostasis function, providing a theoretical basis for analyzing the regulatory mechanism of piglet iron response. - Source: PubMed
Publication date: 2025/10/14
Qian HaimingWang PingLi TengchuanZhang ChunyongLi JintaoWang QingliangRen HaiyangJin FanyuHuang JieYao JunPan HongbinGuo RongfuAn Qingcong