Ask about this productRelated genes to: PPARGC1B Blocking Peptide
- Gene:
- PPARGC1B NIH gene
- Name:
- PPARG coactivator 1 beta
- Previous symbol:
- -
- Synonyms:
- PERC, PGC1B
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-03
- Date modifiied:
- 2016-10-05
Related products to: PPARGC1B Blocking Peptide
Related articles to: PPARGC1B Blocking Peptide
- Diabetic kidney disease (DKD) remains a leading cause of end-stage renal disease despite advances in glucose-, blood pressure-, and albuminuria-lowering therapies. The glucose-responsive transcription factor carbohydrate response element-binding protein (ChREBP; encoded by ) regulates glycolytic-lipogenic programs, yet its causal contribution to renal injury is challenging to disentangle in advanced DKD, where bulk kidney transcriptomes reflect tissue remodeling and cellular compositional shifts. - Source: PubMed
Publication date: 2026/04/15
Liu MingliangChen ShihangWu ShiSun BeiChen Liming - Obesity is associated with hypothalamic dysfunction characterized by neuroinflammation and altered transcriptional programs. While resveratrol (RSV) has shown beneficial metabolic effects in peripheral tissues, its central effects on hypothalamic gene expression in obesity remain poorly understood. This study provides the first predictive transcriptomic analysis of the hypothalamic response to RSV in a mouse model of diet-induced obesity. C57BL/6 male mice were fed a high-fat diet (HFD) to induce obesity and then subsequently treated with RSV. Hypothalamic RNA was extracted and analyzed using RNA sequencing. Differentially expressed genes (DEGs) were identified and functionally analyzed through KEGG pathway analysis. Although RSV did not significantly alter body weight, it reversed the expression of several HFD-induced DEGs. Key genes modulated by RSV included , , , , , , , , and , which are involved in inflammation, lipid metabolism, mitochondrial function, and immune signaling. Pathway enrichment analysis revealed significant modulation of TNF and NF-κB signaling, cytokine-cytokine receptor interactions, glycosphingolipid biosynthesis, and phagosome-related activity. Remarkably, 45% of RSV-responsive transcripts were non-coding RNAs, suggesting epigenetic regulation. RSV reprograms the hypothalamic transcriptome in obesity, targeting both coding and non-coding RNAs associated with inflammation and metabolic regulation, independently of weight loss. These findings identify RSV as a potential central modulator of metabolic dysfunction and highlight the hypothalamus as a promising therapeutic target in obesity-related disease. - Source: PubMed
Publication date: 2026/02/28
De la Cruz-Concepción BrendaMendoza-Bello Juan MiguelBeltrán-Anaya Fredy OmarRamírez MónicaFlores-Cortez Yaccil AdileneDamian-Sánchez GemaFlores-Alfaro EugeniaParra-Rojas IselaDel Moral-Hernández OscarCruz MiguelEspinoza-Rojo Mónica - Consumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of this pilot study was to explore potential epigenetic associations between DNA methylation markers in blood and adherence to an MD in pregnancy. - Source: PubMed
Publication date: 2026/02/13
Tavelli GraceSchultz NikkiBrisbane JoannaKresoje NinaLodge SamanthaNicholson Jeremy KArmstrong Nicola JSilva DesireeD'Vaz NinaMartino David - The rising incidence of clear cell renal cell carcinoma (ccRCC) with current treatments offering limited survival benefits and a poor prognosis. Mitochondrial abnormalities impact tumor immunity, progression, and metastasis, and the role of mitochondrial energy metabolism-related genes (MMRGs) in ccRCC remains largely unexplored. This study analyzed TCGA-KIRC, GSE159115, and GSE29609 datasets to identify differentially expressed (DE) MMRGs and their functions. It used LASSO and Cox models to select prognostic MMRGs for model building, created a nomogram (based on independent factors) in TCGA-KIRC (evaluated via calibration and ROC curves), and conducted GSEA, immune cell correlation analyses, TF-miRNA-mRNA network studies, qRT-PCR (ccRCC vs. controls), and WB (RIPA) for biomarker validation. A study of 103 DE-MMRGs highlighted their link to fatty acid metabolism and peroxisome proliferator-activated receptor (PPAR) signaling. Machine learning assessed the prognostic potential of these DE-MMRGs, which yielded a risk model based on six key biomarkers. The constructed prognostic model exhibited outstanding performance in both training and validation sets. This study also explored immune cell relevance and regulatory networks and elucidated complex mitochondrial-tumor interactions. The validation of predictive biomarker expression in clinical samples underscored their role in refining prognostic assessment and therapeutic strategies for ccRCC. In this study, six mitochondrial energy metabolism-related prognosis biomarkers (COX7B, PPARGC1B, NDUFA11, PFKFB4, NDUFV2, and NDUFA7) were screened. A risk model was developed to provide a new reference for the prognosis of ccRCC patients. - Source: PubMed
Publication date: 2025/12/09
Peng YinqiZhang DahaoWang ShuangyuHuang FuHuang Haipeng - To evaluate the roles of miR-137 and its target genes in lipid metabolism and prostate tumorigenesis. - Source: PubMed
Publication date: 2025/09/01
Silva Karina Serafim daGuimarães Vanessa RibeiroMaluf Feres CamargoSantos Gabriel Arantes DosCamargo Juliana Alves deSilva Iran Amorim daLeite Katia Ramos MoreiraReis Sabrina Thalita DosViana Nayara IzabelSrougi MiguelPimenta Ruan