Ask about this productRelated genes to: MTUS1 Blocking Peptide
- Gene:
- MTUS1 NIH gene
- Name:
- microtubule associated scaffold protein 1
- Previous symbol:
- -
- Synonyms:
- MTSG1, KIAA1288, DKFZp586D1519, FLJ14295, ATIP1, MP44, ATBP, ICIS, ATIP3
- Chromosome:
- 8p22
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-05
- Date modifiied:
- 2018-11-16
Related products to: MTUS1 Blocking Peptide
Related articles to: MTUS1 Blocking Peptide
- Cardiac fibrosis is a common pathological feature during the progression of various cardiovascular diseases and is characterized by excessive deposition of extracellular matrix (ECM) in the myocardial interstitium, accompanied by alterations in cardiac structure and function. MicroRNAs (miRNAs) play important roles in the regulation of cardiac fibrosis. Previous studies have suggested that miR-34a is involved in fibrotic processes; however, its in vivo effects on cardiac fibrosis and cardiac function, as well as its relationship with mitochondrial tumor suppressor 1 (MTUS1), remain unclear. This study aimed to investigate the effects of miR-34a targeting MTUS1 on cardiac fibrosis and cardiac function in rats through in vivo intervention. - Source: PubMed
Hu JiajiaLu XiaoxuYan JianqinXie ZhongshangZhang JunjieZhang Chengliang - Esophageal squamous cell carcinoma (ESCC) exhibits aggressive malignant behaviors. Microtubule associated scaffold protein 1 (MTUS1) has been recognized as a potential tumor suppressor, yet its roles and functional mechanisms in ESCC remain unclear. - Source: PubMed
Publication date: 2026/03/19
Jiang ChenmingLu QuanlingWang AnChen HaoYao Lishuai - : Melanoma, characterized by high rates of metastasis and recurrence, is a particularly aggressive malignant tumor. The underlying mechanisms driving its progression remain enigmatic. The close interplay between tumor and non-tumor cells is pivotal, significantly shaping the tumor microenvironment. Extracellular vesicles emerge as a crucial vector influencing this environment, as they can modulate cellular mechanisms and biological functions-marking a key frontier in tumor mechanism research. However, the potential impact of intercellular communication on tumor cell biology remains largely unexplored. : In the study, we employed a pair of cell lines derived from melanoma M14 cells, designated as highly metastatic cells (POL cells) and the low metastatic cells (OL cells), and elucidate their characteristics. : Our findings revealed that POL cells can potentiate the metastatic potential of OL cells through the transfer of extracellular vesicles, which harbor functional microRNAs, specifically in this context. Upon entering OL cells, the EV- orchestrates changes in the m6A modification levels of the mRNA of tumor suppressor genes and . : This modulation subsequently influences the expression of these genes and, in turn, the invasive behavior of OL cells. - Source: PubMed
Publication date: 2026/02/28
Li ChenshiLi JieHan XueChen YutingShi LeiXiang MengZhang YuhanChen YanLi BowenTang YaoTan JiyuXie JiachengXing H RosieWang JianyuChen MoHuang Guoning - M2 macrophages significantly contribute to the advancement of prostate cancer (PCa). This research aims to pinpoint M2 macrophage-associated genes (M2RGs) by leveraging single-cell analyses, with a focus on evaluating their prognostic and therapeutic implications in PCa. - Source: PubMed
Publication date: 2026/02/27
Wu ZhikaiLi JianxinHu JintaoLai CongLi ZhuohangYu HaoYuan ZhihanDai MingzhouShi JuanyiLiu ChengXu Kewei - Although previous studies have linked colorectal cancer (CRC) with lipid metabolism and inflammatory signaling, the specific roles of phosphatidylcholine metabolites and their interactions with inflammatory cytokines in the tumor microenvironment remain poorly understood. - Source: PubMed
Publication date: 2026/01/02
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