Ask about this productRelated genes to: HIST1H3A Blocking Peptide
- Gene:
- HIST1H3A NIH gene
- Name:
- histone cluster 1 H3 family member a
- Previous symbol:
- H3FA
- Synonyms:
- H3/A
- Chromosome:
- 6p22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-07
- Date modifiied:
- 2016-08-15
Related products to: HIST1H3A Blocking Peptide
Related articles to: HIST1H3A Blocking Peptide
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Sasamoto NaokoNgo Long HVitonis Allison FDillon Simon TAziz MaryamShafrir Amy LMissmer Stacey ALibermann Towia ATerry Kathryn L - Celastrol, an active ingredient derived from , has shown therapeutic potential for various kidney renal diseases. The kidney protective activity of celastrol is mainly exerted through anti-inflammatory, and antioxidant effects. However, celastrol causes dose-dependent kidney toxicity, which results in increased risks of mortality among patients. This study aimed to develop a kidney organoid-based prediction system to assess the safety and efficacy of celastrol in reducing cisplatin-induced nephrotoxicity. - Source: PubMed
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Shen ChongayngWang QizhengYe XunZhou YiXing HuayangPan ChengjieLi HeyingWu ChunjieYou Mingliang - The rising prevalence of Type 2 diabetes mellitus (T2D) in the Qatari population presents a significant public health challenge, highlighting the need for innovative approaches to early detection and management. While most efforts are centered on using blood samples for biomarker discovery, the use of saliva remains underexplored. - Source: PubMed
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Murugesan SelvasankarYousif GhadaDjekidel Mohamed NadhirGentilcore GiusyGrivel Jean CharlesAl Khodor Souhaila - Gout is a prevalent manifestation of metabolic osteoarthritis induced by elevated blood uric acid levels. The purpose of this study was to investigate the mechanisms of gene expression regulation in gout disease and elucidate its pathogenesis. - Source: PubMed
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Yang YubiaoHu PingZhang QinnanMa BoyuanChen JinyuWang BitaoMa JunLiu DerongHao JianZhou Xianhu - An automated proteomic platform for producing and screening an array of functional proteins on biosensor surfaces was developed to address the challenges of measuring proteomic interaction kinetics in high throughput (HTP). This technology is termed Sensor-Integrated Proteome On Chip (SPOC) which involves cell-free protein expression in nano-liter volume wells (nanowells) directly from rapidly customizable arrays of plasmid DNA, facilitating simultaneous capture-purification of up to 2400 unique full-length folded proteins onto a 1.5 sq-cm surface of a single gold biosensor chip. Arrayed SPOC sensors can then be screened by real-time label-free analysis, including surface plasmon resonance (SPR) to generate kinetic affinity, avidity data. Fluorescent and SPR assays were used to demonstrate zero crosstalk between protein spots. The functionality of the SPOC protein array was validated by antibody binding assay, post-translational modification, mutation-mediated differential binding kinetics, and catalytic activity screening on model SPOC protein arrays containing p53, Src, Jun, Fos, HIST1H3A, and SARS-CoV-2 receptor binding domain (RBD) protein variants of interest, among others. Monoclonal antibodies were found to selectively bind their target proteins on the SPOC array. A commercial anti-RBD antibody was used to demonstrate discriminatory binding to numerous SARS-CoV-2 RBD variants of concern with comprehensive kinetic information. With advantages of HTP, flexibility, low-cost, quick turnaround time, and real-time kinetic affinity profiling, the SPOC proteomic platform addresses the challenges of interrogating protein interactions at scale and can be deployed in various research and clinical applications. - Source: PubMed
Publication date: 2024/01/24
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