Ask about this productRelated genes to: LETM2 Blocking Peptide
- Gene:
- LETM2 NIH gene
- Name:
- leucine zipper and EF-hand containing transmembrane protein 2
- Previous symbol:
- -
- Synonyms:
- FLJ25409, SLC55A2
- Chromosome:
- 8p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-09
- Date modifiied:
- 2017-11-24
Related products to: LETM2 Blocking Peptide
Related articles to: LETM2 Blocking Peptide
- Background A major complication of diabetes, diabetic foot ulcers (DFU), has been linked to mitochondrial dysfunction and oxidative stress. Here, we performed analysis of RNA sequencing data from publicly available databases, including single-cell assays, to identify dysregulated genes associated with these processes in DFU and the specific cell types involved. Methods Analysis of transcriptome sequencing was performed on GSE134431 and GSE80178 datasets from the GEO database to identify differentially expressed mitochondrial-related genes (DE-MRGs) in DFU samples relative to controls. LASSO and SVM-RFE algorithms were used to identify critical genes, and functional enrichment analyses were conducted to identify associated pathways. Results were validated in a cohort of DFU samples and controls processed at our institution, and single-cell RNA sequencing data from GSE245703 was used to determine expression of candidate genes in endothelial cells from DFU relative to non-DFU samples. SiRNA knockdown of one candidate gene, LETM2, was performed in human umbilical vein endothelial cells (HUVECs) exposed to HO as a model system for oxidative stress. Results LETM2 emerged as key gene significantly associated with DFU from our integrated analysis of the DFU RNA sequencing datasets. Single-cell RNA sequencing data revealed increased expression of LETM2 in endothelial cells from DFU samples compared to controls. Transcriptome sequencing of RNA from HUVECs with LETM2 knockdown under oxidative stress conditions revealed corelated expression with other genes involved in mitochondrial function. HUVECs with LETM2 knockdown furthermore showed impaired mitochondrial fission and mitophagy, as well as decreased cell viability and increased apoptosis in vitro. Conclusions These findings indicate a role for LETM2 in preserving mitochondrial function in HUVECs under oxidative stress and underscore its potential as a therapeutic target for mitigating mitochondrial dysfunction in diabetic complications such as DFU. - Source: PubMed
Publication date: 2025/11/22
Su NanWang JiweiXue ZhiweiPeng ShujieXing WenchenJin HaoyongZhao JiangliHe YanyaShi JiaqiLi WenboWei QijianHuang BinLi ChaoWang XinyuLiu PeiYang Ning - In the United States, African Americans (AA) have higher Pancreatic ductal adenocarcinoma (PDAC) incidence and mortality rates than Caucasian Americans (CA). This study aimed to identify distinct gene expression signatures and differentially regulated pathways in AA and CA PDACs. - Source: PubMed
Publication date: 2025/07/04
Bajpai PrachiPaluri RaviDiffalha Sameer AlChandrashekar Darshan SAfaq FarrukhOtali DennisElkholy AmrMiller C RyanPeter ShajanManne AshishNagaraju Ganji PurnachandraSaddala Madhu SudhanaKhushman Moh'dVarambally SooryanarayanaManne Upender - : Finding single nucleotide polymorphisms (SNPs) and candidate genes that influence the expression of key traits is essential for genomic selection and helps improve the efficiency of poultry production. Here, we aimed to conduct a genome-wide association study (GWAS) for egg production traits in an F resource population of chickens (). : The examined F population was produced by crossing two divergently selected breeds with contrasting phenotypes for egg performance traits, namely Russian White (of higher egg production) and Cornish White (of lower egg production). Sampled birds ( = 142) were genotyped using the Illumina Chicken 60K SNP iSelect BeadChip. : In the course of the GWAS analysis, we were able to clarify significant associations with phenotypic traits of interest and economic value by using 47,432 SNPs after the genotype dataset was filtered. At the threshold < 1.06 × 10, we found 23 prioritized candidate genes (PCGs) associated with egg weight at the age of 42-52 weeks (, ), duration of egg laying (), egg laying cycle () and egg laying interval (, , , , , , , , , , , , , , , , , , ). Moreover, two SNPs were co-localized within the gene. : Based on our GWAS findings, the revealed SNPs and candidate genes can be used as genetic markers for egg weight and other performance characteristics in chickens to attain genetic enhancement in production and for further genomic selection. - Source: PubMed
Publication date: 2025/05/15
Volkova Natalia ARomanov Michael NDzhagaev Alan YuLarionova Polina VVolkova Ludmila AAbdelmanova Alexandra SVetokh Anastasia NGriffin Darren KZinovieva Natalia A - Gastric cancer (GC) is a common and aggressive type of cancer worldwide. Despite recent advancements in its treatment, the prognosis for patients with GC remains poor. Understanding the mechanisms of cell death in GC, particularly those related to mitochondrial function, is crucial for its development and progression. However, more research is needed to investigate the significance of the interaction between mitochondrial function and GC cell death. - Source: PubMed
Publication date: 2024/04/23
Ma YimengJin JingjingXue ZixuanZhao JungangCai WeiyangZhang Wanli - Copy number alterations are common genetic lesions in cancer. In squamous non-small cell lung carcinomas, the most common copy-number-altered loci are at chromosomes 3q26-27 and 8p11.23. The genes that may be drivers in squamous lung cancers with 8p11.23 amplifications are unclear. - Source: PubMed
Publication date: 2023/02/21
Voutsadakis Ioannis A