Ask about this productRelated genes to: GABRE Blocking Peptide
- Gene:
- GABRE NIH gene
- Name:
- gamma-aminobutyric acid type A receptor epsilon subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1997-03-19
- Date modifiied:
- 2016-02-04
Related products to: GABRE Blocking Peptide
Related articles to: GABRE Blocking Peptide
- Asymptomatic bacteriuria (ASB) is more widespread in postmenopausal women, especially among diabetic women. Nevertheless, a comprehensive definition of independent predictors of ASB in the general postmenopausal population and in the high-risk diabetic subgroup remains critical for management strategies. - Source: PubMed
Publication date: 2026/04/13
Ashur Abir BenGashout AishaAbou-Aisha KhaledSalem Abeer MGabre Refaat M - Metastatic colorectal cancer (mCRC) remains a significant clinical challenge, with a 5-year survival rate of 10%. Approximately 40% of CRCs harbor mutations in the KRAS gene, leading to poor response to standard therapy. This underscores the crucial need for novel therapeutics targeting KRAS and overcoming the growing barrier of resistance. To address these critical challenges, we conducted a high-throughput screen to identify small molecules that synergize with the KRAS inhibitor MRTX1133 against CRC. Through screening a 2,652-kinase inhibitor library, we discovered that Osimertinib, an EGFR tyrosine kinase inhibitor, and its analogs strongly synergize with MRTX1133 against both parental and MRTX1133-resistant cells. The top compound from the screen, NT-1, is a chemical analog of Osimertinib. NT-1 strongly synergized with MRTX1133 to suppress EGFR/MAPK signaling and induce apoptosis in an MRTX1133-resistant patient-derived organoid model of CRC. We present novel small molecule combinations with the potential to overcome the limitations of KRAS inhibitors with direct clinical translational applications. - Source: PubMed
Publication date: 2026/04/08
Thielen NatalieWei NingNagai EmikoHouston MicheleAugenlicht Leonard HShin Alice EGabre Joel TRustgi Anil KHa GraceLaFave Lindsay MChu EdwardKitamura SeiyaKuang Chaoyuan - Use of minimally invasive surgical (MIS) techniques in the management of patients with inflammatory bowel disease (IBD) is increasing. The aim of this study was to compare postoperative morbidity in patients who underwent planned open procedures to those who had an unplanned conversion to open. - Source: PubMed
Publication date: 2026/02/19
Radomski Shannon NConsul MichaelStem MiloslawaBrown Lawrence BGabre-Kidan AlodiaGraham Ada EBafford Andrea CObias Vincent J - Preeclampsia (PE) is a serious complication of pregnancy that affects the offspring and mothers. Those with a history of PE are at higher risk of future cardiometabolic diseases, the etiology of which remains uncertain. - Source: PubMed
Publication date: 2026/02/19
Cheng Yu-ChunLai Yun-JuLian Wei-ShiungTsai Ching-ChangCheng Hsin-HsinYu Hong-RenTiao Mao-MengSheen Jiunn-MingHsu Ying-LunWang Feng-ShengLin I-Chun - The molecular underpinnings contributing to the onset of Barrett's esophagus (BE) remain elusive. By studying familial clusters of the disease, here we identify a significant association between genetic variants in the V-set and Immunoglobulin Domain Containing 10 Like (VSIG10L) gene and BE predisposition. Using mammalian tissues and patient-derived organoids, we show VSIG10L is selectively expressed in the suprabasal squamous cells of the esophageal mucosa and is essential for epithelial maturation and homeostasis. Mice carrying human-orthologous germline mutations in Vsig10l exhibit loss of desmosomes, concomitant with disrupted epithelial differentiation programs, in the squamous mucosa. Upon long-term exposure to a bile acid (deoxycholate) supplemented diet, Vsig10l-mutant mice develop overt BE-like lesions in the forestomach. Furthermore, loss of esophageal VSIG10L expression is observed frequently in patients with chronic gastroesophageal reflux disease, a known risk factor for BE. Collectively, our study uncovers a fundamental link between VSIG10L, esophageal homeostasis, and BE predisposition. - Source: PubMed
Publication date: 2026/01/29
Ravillah DurgadeviSingh SalendraKatabathula Ramachandra MKresak Adam MUdhayakumar BhavathariniGupta RajeshBrock WendyMitani YosukeJain VaibhavHocke EmilyGregory Simon GGarman Katherine SGabre Joel TFujioka HisashiWillis Joseph EChak AmitabhGuda Kishore