Ask about this productRelated genes to: CUTC Blocking Peptide
- Gene:
- CUTC NIH gene
- Name:
- cutC copper transporter
- Previous symbol:
- -
- Synonyms:
- CGI-32
- Chromosome:
- 10q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-20
- Date modifiied:
- 2016-10-05
Related products to: CUTC Blocking Peptide
Related articles to: CUTC Blocking Peptide
- Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, is linked to cardiovascular, neurodegenerative, and metabolic diseases. Emerging evidence indicates a bidirectional interaction between the periodontal pathogen () and gut microbiota, potentially influencing host TMAO metabolism. However, whether modulates the choline-trimethylamine (TMA) axis remains unclear. - Source: PubMed
Publication date: 2026/04/07
Xie WeigeHan DongTan JinluZhao DanDong JingwenWu JuanYang XuebinXie Sijing - The interplay between gut microbiota and the mucosal immune system critically regulates systemic immunity and disease susceptibility. Here, we demonstrate that intestinal epithelial Toll-like receptor (TLR)4 deficiency reshaped the gut microbiome and subsequently exacerbated atopic dermatitis (AD) in mice. Mechanistically, TLR4 deficiency reduced Akkermansia muciniphila abundance and enriched choline trimethylamine-lyase (CutC)-expressing bacteria. This enhanced microbial choline-to-trimethylamine conversion and elevated circulating trimethylamine oxide (TMAO) levels. Clinically, AD patients exhibited increased plasma TMAO levels that positively correlated with disease severity and immunoglobulin E (IgE) levels. UK Biobank data also showed that higher dietary choline intake was associated with increased AD risk. TMAO promoted T helper (Th)2 differentiation by directly interacting with protein phosphatase 5 (PPP5) and enhancing PPP5-mediated dephosphorylation of PPARγ. CD4 T cell-specific PPARγ deletion abolished TMAO-driven skin pathology in AD mice. Our results reveal intestinal dysbiosis, as a result of innate immune deficiency, as a driver of inflammatory Th2 cells and AD pathology, highlighting a link among the gut immune environment, microbial metabolites, and skin disease. - Source: PubMed
Publication date: 2026/04/16
Yu LuPeng ShuyingChen XiWu TianxingDong LijunLuo JialiangXu ShuangbinZhou JiaZhao XiaoshanZheng LeiShu GangWang XueminHuang LipingChen QingyunJiang DekeSun Liang-DanHylemon PhillipWang Xiang-YangSun LedongMa LiZuo Daming - Choline can be metabolized by gut bacteria with a choline utilization gene, CutC, as identified through genome sequencing studies. This metabolism produces trimethylamine, the precursor to the atherosclerotic metabolite trimethylamine N-oxide (TMAO). Bacterial species involved in trimethylamine production in free-living humans have been under-investigated. We previously developed the TMAO dietary pattern (TMAO-DP), which is predictive of plasma TMAO and choline. We evaluated associations between the TMAO-DP, dietary choline, and choline-rich foods (fish, red meat, eggs) with the abundance of species with CutC. We also explored associations between the TMAO-DP and microbiome diversity. - Source: PubMed
Publication date: 2026/02/18
Burns Kaelyn FBlair Rachael HagemanMares Julie ALaMonte Michael JWactawski-Wende JeanMcSkimming DanielLiu ZheMillen Amy E - The excretion of the anthelmintic drug albendazole (ALB) from treated animals into the soil, as well as its widespread application as a fungicide, poses a serious ecological risk to the soil environment. In this study, we investigated the degradation of ALB in soil and its bioaccumulation in earthworms, changes in the microbiome and degradation genes, and the effect of zinc oxide nanoparticles on the degradation and enrichment behaviors of ALB and microbial community structure and function. Our findings showed that ALB selectively enriched specific albendazole degradation genes (i.e., hmr and ami) in the earthworm, preferentially activating the pathways associated with sulfur reduction, amination of ALB sulfone, and hydroxylation of ALB. Metagenomic analysis revealed that the relative abundances of ppo, xylA, cutC, and nfsl in the earthworm gut were 0.19-52.64-fold higher in the ALB treatment than in the control, indicating their potential dominance in ALB biodegradation. Network analysis further identified potential bacterial hosts carrying biodegradation genes and albendazole degradation genes. Notably, Sphaerobacter, Saccharothrix, Actinomadura, and Nocardia were recognized as potential dual hosts of biodegradation genes and albendazole degradation genes, displaying a 0.05-1.32-fold elevation in relative abundance in ALB-treated earthworm guts compared to the control. Additionally, ZnO nanoparticles were found to reduce ALB bioaccumulation in earthworms and accelerate its dissipation in soil. These findings provide novel insights into the bioremediation mechanisms of pesticides in soil-earthworm ecosystems. - Source: PubMed
Publication date: 2026/03/09
Wang JiaoGe HongnuoLiu YinuoHuang ChenyuZhang LuqingYu YunlongXu LihuiFang Hua - High-fat diet-induced metabolic disorders are associated with trimethylamine (TMA)/trimethylamine -oxide (TMAO), whose production is linked to gut microbial choline metabolism. However, changes in specific gut microbiota under a high-fat diet and the relationship between these changes and choline in TMA/TMAO production remain unclear. - Source: PubMed
Publication date: 2026/02/17
Wang ZhuoWei JiayingHuang ZixinLiu XiangLi ShanshanFang ZhengfengHu LiangLi RanTao LisiLi ChengChen Hong