Ask about this productRelated genes to: PILRB Blocking Peptide
- Gene:
- PILRB NIH gene
- Name:
- paired immunoglobin like type 2 receptor beta
- Previous symbol:
- -
- Synonyms:
- FDFACT1, FDFACT2
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-09-10
- Date modifiied:
- 2019-02-21
Related products to: PILRB Blocking Peptide
Related articles to: PILRB Blocking Peptide
- Dementia with Lewy Bodies (DLB) is the most common neurodegenerative dementia after Alzheimer's disease (AD), but it remains challenging to diagnose due to overlapping symptoms and mixed pathologies. This pilot study tested whether DLB has different metabolic blood proteomic profiles compared to AD and controls. Serum was analysed from people with DLB ( = 20), a group with AD (either with Alzheimer's disease dementia or Mild Cognitive Impairment with a positive amyloid positron emission tomography scan (MCI+/AD) ( = 15), and similarly aged controls ( = 15) using the Olink Metabolism panel encompassing 92 proteins. Six proteins (PILRB, LRIG1, NECTIN2, TINAGL1, SSC4D, and FKBP4) were significantly different in DLB compared with the controls, and one protein (SERPINB8) was differentially expressed when compared with MCI+/AD. Receiver operating characteristic curves for biologically relevant proteins that have previously established roles in neurodegenerative and cognitive properties showed that RNASE3 levels could differentiate DLB from MCI+/AD (area under the curve (AUC) = 0.717, sensitivity = 0.850, and specificity = 0.600). A multimarker model incorporating RNASE3 with phosphorylated tau 217 (pTau217) and polygenic risk scores for LBD achieved improved accuracy in discriminating DLB from MCI+/AD (AUC = 0.963, sensitivity = 1.000, and specificity = 0.900). Pathway analyses revealed dysregulation in cortisol signalling, inflammation resolution, and ErbB4-mediated neuroplasticity, which point towards peripheral protein alterations related to the adaptation to stress, immune regulation, and synaptic integrity in DLB. The present exploratory study highlights potential pathophysiological mechanisms implicated in DLB, suggesting that a multimodal biomarker panel may perform better compared to single proteins. Considering the small sample sizes, the findings will need to be replicated in larger cohorts. - Source: PubMed
Publication date: 2026/07/31
Pritha Ariana NChouliaras LeonidasSwann PeterPrats-Sedano MariaMcKeever AnnaHeslegrave AmandaAshton Nicholas JZetterberg HenrikSu LiMalpetti MauraRowe James BO'Brien John T - The purpose of this study was to investigate whether the genetic architecture of translaminar cribrosa pressure difference (TLCPD) provides genetic insights based on dual-pressure theory beyond intraocular pressure (IOP) and whether a TLCPD-based polygenic risk score (PRS) predicts primary open-angle glaucoma (POAG) risk and its pleiotropic effects. - Source: PubMed
Hong In-ShikCho ChamleeKim BeomsuShim InjeongLee Yeong ChanJung Sang-HyukSong MinkuPark SanghyeonHong SanghoonJo HyeonbinKim HoyoungSeo Je HyunWon Hong-Hee - Age-related macular degeneration (AMD) is a common, complex disease affecting older individuals that can lead to severe vision loss. It is characterized by early anatomical changes in the retina, retinal pigment epithelium (RPE), and choroid, especially in the central (macular) region. AMD can progress to severe atrophy and/or pathologic angiogenesis that leads to visual decline. Over 30 genetic loci have been identified as contributing to AMD risk; however, the mechanisms by which genetic variants affect pathology has not been thoroughly explored. In this report we examined single-nucleus gene expression in the retina, RPE and choroid of 88 individuals categorized by AMD stage, as well as 37 previously published samples. Genotyping was performed on 1.8 million SNPs, with additional SNPs imputed, on each donor to identify expression quantitative trait loci (eQTLs). We found that two AMD-risk loci (PILRB and ARMS2/HTRA1) affected the expression of PILRB and HTRA1, respectively. The risk allele of PILRB was associated with increased RNA in cones, fibroblasts, choroidal macrophages, and RPE, whereas the HTRA1 risk locus was associated with decreased RNA in the RPE. We also identified an age-related decrease in complement inhibitors in the choriocapillaris, a tissue susceptible to complement mediated damage in AMD. - Source: PubMed
Publication date: 2026/04/01
Voigt Andrew PMullin Nathaniel KMulfaul KellyLozano Lola PNavratil Emma MFlamme-Wiese Miles JLavine Jeremy AFingert John HTucker Budd AStone Edwin MScheetz Todd EMullins Robert F - The coronavirus disease 2019 (COVID-19) pandemic, caused by SARS-CoV-2, showed a wide range of host responses from no symptoms to severe illness, highlighting the urgent need for better diagnostic and therapeutic solutions. Untargeted metabolomics offers a way to uncover molecular and biochemical changes linked to immune differences, potentially identifying biomarkers for early detection and treatment monitoring. - Source: PubMed
Publication date: 2026/01/21
Al Eissa Mariam MAlMalki Reem HAlahmari RandhAlQurashi Raghad AHawsa Esraa ABen Shaded MuathAlrukhayes MoneraAlsaieedi Ahdab AMall YousefMasood AfshanAlmudrra Sami SAlAbdulkareem Khaled IAlAnazi Khalid HAlfadda Assim AAlBarraq AhmedAsiri Abdullah MJokhdar Hani AAbdel Rahman Anas - BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disease with limited prevention and treatment options.ObjectiveWe aimed to identify proteins with genetically regulated plasma levels associated with AD and its related phenotypes.MethodsWe conducted a proteome-wide association study (PWAS) using Olink-based plasma proteomes (N = 45,540) from the UK Biobank Pharma Proteomics Project (UKB-PPP) and a large-scale genome-wide association study for AD (N case = 85,934, N control = 401,577). To validate and expand these findings, we conducted longitudinal analyses of AD and mild cognitive disorder (MCD) over a 13.7-year follow-up, along with genetic-based PWAS analyses and cross-sectional studies on hippocampal volume. Protein-protein interaction networks were constructed to explore mechanistic association.ResultsWe identified 30 AD-associated plasma proteins by PWAS, including 17 previously reported and 13 novel candidates (including FES, LRP11, and HDGF). Longitudinal cohort studies supported the role of PILRB and FES in AD and/or MCD. Additionally, the genetically determined higher levels of LRP11 were found to be associated with an increased hippocampal volume, including its subdivisions, along with a reduced risk of AD. In contrast, higher plasma levels of HDGF were linked to a decreased hippocampal volume, accompanied by an increased risk of AD. Protein-protein interaction analysis linked PILRA, PILRB, FES, and LRP11 to several pathological proteins associated with AD, including BIN1, ABCA7, and SORL1.ConclusionsThis study identified 13 novel candidates, with potential roles in hippocampal volume and AD risk, providing insights into disease mechanisms. - Source: PubMed
Publication date: 2025/12/29
Sun LingyunWei GuikangJi FeiyangDing YihongFan JiayaoXu YueHe ChunfengZhou YuanLiu ZuyunSun ZeyuZhou Dan