Ask about this productRelated genes to: CEACAM6 Blocking Peptide
- Gene:
- CEACAM6 NIH gene
- Name:
- carcinoembryonic antigen related cell adhesion molecule 6
- Previous symbol:
- NCA
- Synonyms:
- CD66c
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
Related products to: CEACAM6 Blocking Peptide
Related articles to: CEACAM6 Blocking Peptide
- Gallbladder cancer (GBC) is a highly lethal disease which is usually diagnosed at advanced stage owing to unavailable screening tools and effective therapies. Persistent inflammation induced by various risk factors is the main cause of GBC, however, the molecular program remains elusive. Unveiling the molecular trajectory and events during gallbladder epithelium malignant transformation contribute to prevention and drug discovery for GBC. Single cell RNA sequencing was performed by using 4 gallbladder adenoma and cancer samples. Pseudotime trajectory analyses were employed to reconstruct epithelium transformation track in order to identify crucial genes which promoted GBC development. Functional and mechanism studies were performed to validate the regulatory network and cell behavior in vitro and in vivo. Three clusters of gallbladder epithelium were identified among GBC microenvironment which were characterized by distinct epithelial mesenchymal transition (EMT) and inflammation states. Cell adhesion molecular binding was the most significant GO term between EMT high and low states, in which OLFM4 was differentially expressed gene participated. Further studies implicated that OLFM4 could promote GBC metastasis and activate EMT through CEACAM6/AKT signaling cascade, and the CEACAM6 expression was regulated by TGF-β/Smad3 pathway. Interestingly, we disclosed that TGFβR1 was the functional receptor of OLFM4, through which the tumorigenic signaling of OLFM4 was transduced. These findings suggest the oncogenic role of OLFM4 during GBC carcinogenesis which can be a candidate biomarker of GBC, and OLFM4, TGFβR1 and downstream signaling elements are promising therapeutic targets for GBC. - Source: PubMed
Publication date: 2026/04/29
Yang SonglinHuang WenwenZeng QingjuWang XiaodanLin ShuchengMeng MingyaoWang LiqiongWang HuiWang RuotianLi LinChen XiaofangWei ZichunLin ZhuyingYe QiuwenLi RuhongTan JingWang Wenju - Invasive candidiasis is a fungal infection characterized by a high mortality rate. Carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family receptors play a crucial role in regulating innate responses of both leukocytes and epithelia. Human CEACAM3, CEACAM5 and CEACAM6 receptors recognize and are expressed in transgenic CEABAC10 mice. In a murine infection model, CEABAC10 mice exhibited a shortened survival period attributed to an early cytokine storm, an exacerbated acute phase response, and heightened systemic inflammation compared to their wild-type littermates. The livers and kidneys of CEABAC10 mice displayed intensified purulent necrotizing inflammation, accompanied by increased infiltration of neutrophils and macrophages. Our in vivo and in vitro data indicated that the expression of CEACAM6 on monocytes of CEABAC10 mice caused the elevated cytokine levels and the subsequent exacerbation of the acute phase response upon infection, resulting in decreased survival. - Source: PubMed
Publication date: 2026/04/16
Klaile EstherMüller Mario MarcoSonnberger JohannesBothe Anne-KatrinBrehme SaskiaEhrenpfordt JulietKlassert Tilman EikeKuhn SabinaDietert KristinaKershaw OliviaPraetorius Jan-PhilippFigge Marc ThiloBauer TorstenGebhardt AndreasMall GitaJacobsen Ilse DeniseSlevogt Hortense - Identifying viruses with zoonotic potential on the basis of their ability to enter human cells is a critical component of pandemic prediction, prevention and preparedness. Here using a computational approach that retains maximum phylogenetic diversity, we selected an optimal subset of alphacoronavirus spike proteins to screen against broad coronavirus receptor libraries. Most of the selected spike proteins did not use any of the established coronavirus receptors. However, the pseudotyped spike protein of Cardioderma cor (heart-nosed bat) coronavirus KY43 (CcCoV-KY43) could enter human cells. Using a recombinant CcCoV receptor-binding domain (RBD) and a human receptor screening platform, we identified direct interactions with the human CEACAM proteins CEACAM3, CEACAM5 and CEACAM6. Overexpression of human CEACAM6-a protein widely expressed in the human lung-conferred permissivity to otherwise refractory human cells. A crystal structure showed that the RBD binds the amino-terminal IgV-like domain of human CEACAM6. Immune surveillance studies using sera of individuals from the Taveta region of Kenya, where CcCoV-KY43 was identified, did not show significant evidence of recent spillover. Wider characterization of alphacoronaviruses related to CcCoV-KY43 showed that human CEACAM6 is used by two other CcCoVs collected in Kenya. Moreover, there was more restricted nonhuman CEACAM6 tropism for viruses isolated from Rhinolophus bats from Russia and China. Thus, alphacoronaviruses that use CEACAM6 are probably geographically widespread, and viruses from East Africa show potential for transmission to humans. - Source: PubMed
Publication date: 2026/04/22
Gallo GiuliaDi Nardo AntonelloLugano DoreenRoberts Adam JKutima Bernadette AtakuOkombo MosesDewantari Aghnianditya KresnoBuckley Florence M MWright Gavin JNyagwange JamesAgwanda BernardGraham Stephen CBailey Dalan - Biomarkers for colorectal cancer (CRC) measured in blood at various time-points represents potential tools for disease monitoring and additional staging complementing tissue-based diagnostics. Currently, the only marker in routine clinical use is carcinoembryonic antigen (CEA). Other carcinoembryonic antigen-related cell adhesion molecules (CEACAM) such as CEACAM1 and CEACAM6, have been implicated in tumour progression, however their serum levels in relation to clinical features remain insufficiently explored. - Source: PubMed
Publication date: 2026/04/22
Kanani ArezoAlexeeva MarinaVinod RufusPettersson KimLeivo JanneSøreide Kjetil - This study aimed to evaluate the prognostic utility of serum carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) and CEACAM8 levels in children with Mycoplasma pneumoniae pneumonia (MPP). This single-center prospective cohort study enrolled 364 children with confirmed MPP and 160 age-matched healthy controls between February 2023 and May 2025. Serum levels of CEACAM6, CEACAM8, lactate dehydrogenase (LDH), D-dimer, interleukin-6, C-reactive protein, and myeloperoxidase were measured at admission using enzyme-linked immunosorbent assay. Patients were classified into good- (n = 295) or poor-prognosis (n = 69) groups after 1 week of standardized azithromycin therapy based on clinical, radiological, and spirometric criteria. Multivariable logistic regression was used to identify independent predictors of poor outcome. Receiver-operating characteristic curve analysis assessed the predictive performance of CEACAM6 and CEACAM8, individually and in combination, with corresponding areas under the curve. Correlations with inflammatory markers were evaluated using the Spearman rank correlation test. Children with poor outcomes had significantly higher CEACAM6 and CEACAM8 levels at admission (both P < .001). Multivariable analysis identified elevated CEACAM6 (odds ratio = 1.12, 95% confidence interval = 1.05-1.19) and CEACAM8 (odds ratio = 1.09, 95% confidence interval = 1.03-1.15) as independent predictors of poor prognosis. Receiver-operating characteristic analysis demonstrated areas under the curve of 0.771 for CEACAM6, 0.755 for CEACAM8, and 0.826 for their combination. Both biomarkers correlated positively with interleukin-6, C-reactive protein, and myeloperoxidase (all P < .01) and declined significantly after treatment. Serum CEACAM6 and CEACAM8 are independently associated with poor outcomes in pediatric MPP. Their combined use enhances prognostic accuracy and may support early risk stratification in clinical practice. - Source: PubMed
Ge ShenghuaMa LingyanSong Dongqing