Ask about this productRelated genes to: SLC25A25 Blocking Peptide
- Gene:
- SLC25A25 NIH gene
- Name:
- solute carrier family 25 member 25
- Previous symbol:
- -
- Synonyms:
- KIAA1896, PCSCL, MCSC
- Chromosome:
- 9q34.11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-05
- Date modifiied:
- 2016-10-05
Related products to: SLC25A25 Blocking Peptide
Related articles to: SLC25A25 Blocking Peptide
- Physical inactivity contributes to the development of chronic diseases. Activation of orphan nuclear receptors estrogen-related receptors (ERRα/β/γ) has emerged as a molecular strategy to mimic exercise-induced benefits. - Source: PubMed
Publication date: 2026/04/06
de Souza-Lima JosivaldoAstrosa-Martin Benjamín DanielGalaz-Rodríguez Camilo ArturoSilva-Bernal Jorge ErnestoOrellana-Pizarro Luis IgnacioMena-Díaz Carlos Alberto - A genome-wide knockout screen identified members of the SLC25 family of mitochondrial carrier proteins as important regulators of the rate of de novo mitochondrial protein synthesis. To elucidate this relationship, we generated human cell knockouts for SLC25A25, SLC25A44, SLC25A45, and SLC25A48, which have been shown to exchange adenosine triphosphate-magnesium (ATP-Mg) and phosphate, branched-chain amino acids, methylated basic amino acids, and choline, respectively. Multiomic and functional analyses identified that these four carriers are crucial for mitochondrial translation, biogenesis and function of the oxidative phosphorylation system, as well as mitochondrial morphology. Thermostability screens showed that SLC25A48 is specifically stabilized by choline, and changes in the mitochondrial metabolome and lipidome indicated defects in choline biosynthetic pathways and remodeling of mitochondrial membranes, both consistent with SLC25A48 being a choline transporter. These results highlight the essential roles of specific SLC25 transporters in maintaining mitochondrial structure and function and show that impaired transport of branched-chain amino acids, methylated basic amino acids, ATP-Mg, and choline affects mitochondrial translation. - Source: PubMed
Publication date: 2026/02/25
Rudler Danielle LHughes Laetitia AKing Martin SBaker JessicaLee Richard GGandadireja Andrianto PSunil AnishaFagan Samuel VPayne BlakeGray NicolaMcCubbin TimKunji Edmund R SRackham OliverFilipovska Aleksandra - Acute exercise causes a short-term stress, activating immediate gene expression responses. These responses are essential for cellular adaptation and resilience. Endothelial cells, positioned throughout the vasculature, play a central role in sensing and responding to these stress signals. As dynamic regulators of vascular tone, nutrient delivery, and cellular communication, endothelial cells are key integrators of metabolic adaptation. They coordinate intra- and interorgan communication through the release of signaling molecules, shaping systemic responses to exercise. Despite their importance, the endothelial cell-specific transcriptional response to exercise remains poorly understood. To interrogate the transcriptional response to exercise in endothelial cells, we used NuTRAP (Nuclear Tagging and Translating Ribosome Affinity Purification) mouse technology that expresses EGFP/L10a under control of the vascular endothelial-cadherin promoter (). Following a single bout of acute exercise, ribosome-associated mRNA was isolated from endothelial cells from gastrocnemius of both exercised and sedentary animals. RNA sequencing confirmed endothelial cell-specific enrichment and revealed robust changes in gene expression. Exercise induced canonical early response genes (, , and ) and activated pathways related to angiogenesis, oxidative stress, stress kinase signaling, vascular remodeling, and metabolic stress signaling. For context, we analyzed skeletal muscle fiber responses using NuTRAP mice driven by the human α-skeletal actin () mice. Although some genes overlapped, skeletal muscle fiber-enriched pathways included hypoxia response and muscle development. These findings reveal a distinct microvascular endothelial transcriptional signature in skeletal muscle tissue in response to acute exercise, providing insight into the cell-type-specific mechanisms that underlie vascular adaptation and intercellular communication in response to physiological stressors like exercise. This study profiles the endothelial-specific transcriptional response to acute exercise at cell-type resolution. Comparative analysis with skeletal muscle fibers revealed distinct gene expression and upstream regulators. Key findings include endothelial-specific expression of exerkines, metabolic genes, and nitric oxide signaling. These results uncover a molecular basis for endothelial adaptation to exercise and suggest a potential role in mediating systemic exercise benefits. - Source: PubMed
Publication date: 2025/08/11
Addington Adele KWall Rebecca MWei XiaoranFrate Sarah DOlsen Michelle LDrake Joshua CCraige Siobhan M - Mineral elements are crucial for biological functions, with meat serving as a key dietary source. Despite advances in ionome analysis, the genetic mechanisms regulating mineral accumulation in meat remain poorly understood. Here, we analyze the ionome of 376 breast muscles from the large gradient consanguinity segregating population generated by Pekin duck × Liancheng white duck crosses, quantifying 7 essential mineral elements (potassium (K), phosphorus (P), sodium (Na), magnesium (Mg), calcium (Ca), iron (Fe), and zinc (Zn)). Notably, Ca exhibited the most pronounced variation between Pekin duck and Liancheng white duck (fold change = 1.83, P < 0.01). Correlation analysis demonstrated significant positive relationships between Zn and Ca (r = 0.49), Na (r = 0.41), and (all P < 0.001), while negative correlations were observed between Na and K (r = -0.29) (P < 0.001). We then analyzed correlations between the ionomic profiles and growth and meat quality traits. Importantly, Ca concentrations showed strong negative correlations with both breast muscle thickness (r = -0.72) and body weight (r = -0.76) (both P < 0.01), but positively correlated with meat lightness (r = 0.54, P < 0.01). To elucidate the genetic architecture underlying the duck pectoralis muscle ionome, we first estimated its narrow-sense heritability, which ranged from 0.19 to 0.58 across different mineral elements. Through comprehensive genetic analyses incorporating genome-wide association studies, linkage disequilibrium mapping, gene annotation, and expression profiling, we identified 2 key genes (SLC25A25 and ATP2B2) on chromosomes 18 and 13 that collectively regulated Ca content. These lead single nucleotide polymorphisms in these loci explained 39.91% and 11.07% of the phenotypic variance, respectively. Notably, the lead SNP on Chr18 also demonstrated pleiotropic effects, contributing to both meat lightness (PVE = 14.79%) and breast muscle thickness (PVE = 1.79%). Furthermore, on chromosome 2, we discovered a significant SNP associated with both Na and Ca concentrations, accounting for 12.6% and 4.35% of phenotypic variation, respectively. Further analysis pinpointed gene SLC25A32 as the most promising candidate within this genomic region. These findings enhance our comprehension of the genetic basis underlying ion content in meat and offer valuable insights for refining breeding programs, while also providing a new direction for the combat hidden hunger through meat biofortification. - Source: PubMed
Zhang HeYu DaxinLiu DapengTang HeheLiu TongGuo ZhanbaoLiu HongfeiWang ZhenMu QimingLiu SiruiZhang YongfuHou ShuishengZhou Zhengkui - This study aimed to investigate the molecular mechanisms underlying the improvement of aged skeletal muscle atrophy by high-intensity interval training (HIIT) combined with glycine supplementation. - Source: PubMed
Publication date: 2025/04/04
Ni Pin-ShiJia Meng-MengHe Jia-HanYu ZhiLi Fang-Hui