Ask about this productRelated genes to: PBLD Blocking Peptide
- Gene:
- PBLD NIH gene
- Name:
- phenazine biosynthesis like protein domain containing
- Previous symbol:
- -
- Synonyms:
- MAWBP, MAWDBP, FLJ14767
- Chromosome:
- 10q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-11-27
- Date modifiied:
- 2016-04-05
Related products to: PBLD Blocking Peptide
Related articles to: PBLD Blocking Peptide
- A teenager with severe autism and associated behavioral difficulties is scheduled for a dental examination under anesthesia for presumed dental infection. This problem-based learning discussion (PBLD) explores the perioperative considerations associated with a patient who cannot cooperate with entering the hospital. - Source: PubMed
Publication date: 2026/04/02
Brown Sarah EBrown ZoëPatel PriyaGentry Katherine R - Colorectal cancer (CRC) is one of the major cancers that threaten human health. Although the CRC census has been gradually popularized, due to the lack of obvious symptoms in the early stage, it is difficult to detect, and the rapid progression and strong metastasis after onset result in a high incidence of CRC. Therefore, the current research aims to identify more powerful molecular targets and biomarkers for the diagnosis, treatment and clinical research of CRC. - Source: PubMed
Publication date: 2025/12/04
Li YangShi JianFengMei ChaoZhou FangYuanZhao HaoSenZhang Li - [This retracts the article DOI: 10.3892/etm.2019.8080.]. - Source: PubMed
Publication date: 2025/11/17
Wu JiansongNiu QiangYuan JieXu XiaodanCao Liuxia - Precise regulation of stimulator of interferon genes (STING) expression is critical for maintaining immune homeostasis and preventing autoimmune disorders. In this study, phenazine biosynthesis-like domain-containing protein (PBLD) is identified as a key modulator of the STING-dependent antiviral type I interferon (IFN) response by suppressing coiled-coil domain-containing protein 50 (CCDC50)-mediated selective autophagic degradation of STING. Notably, viral infection downregulates PBLD expression through two distinct mechanisms: transcriptional suppression via reduced transcription factor EB (TFEB) activity, and post-translational degradation through an enhanced membrane-associated RING finger protein 2 (MARCH2)-mediated ubiquitin-proteasome pathway. Together, these mechanisms establish a negative feedback loop that facilitates viral immune evasion. Moreover, Pbld-deficient mice exhibit increased susceptibility to human adenovirus type 4 (HAdV-4) infection compared with their wild-type (WT) littermates. Importantly, Pbld-deficiency in the 2,6,10,14-tetramethylpentadecane (TMPD)-induced lupus mice model attenuates STING expression and diminishes autoimmune phenotypes. Clinically, PBLD expression is elevated in patients with systemic lupus erythematosus and positively correlates with STING-driven type I IFN signaling. Taken together, PBLD plays a dual role in STING-mediated innate immunity against viral infection and autoimmunity, highlighting its potential as a therapeutic target for both antiviral infections and autoimmune diseases. - Source: PubMed
Publication date: 2025/11/08
Hou PeiliZhu HongchaoSun XiaonanZhang NiWang SongZheng XuexingWang XiaoyunFeng YueyueZhang FuzhenLi XingyuLi RuiWang XiaomengHan YuanyuanWang JunWang ChuanhongYao XiaoyangWang HongmeiHe Hongbin - Hepatocellular carcinoma (HCC) is a prevalent malignancy with poor prognosis. This study uses integrated bioinformatic analyses to explore potential competing endogenous RNA (ceRNA) network chains in HCC. - Source: PubMed
Publication date: 2025/02/13
Yao Lan-QingDiao Yong-KangGong Jin-BoGu Li-HuiXu Jia-HaoWang Ming-DaLi Chao