LOC606495 Blocking Peptide
- Known as:
- LOC606495 Blocking Peptide
- Catalog number:
- 33r-4524
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- LOC606495 Blocking Peptide
Related genes to: LOC606495 Blocking Peptide
- Gene:
- CYB5RL NIH gene
- Name:
- cytochrome b5 reductase like
- Previous symbol:
- -
- Synonyms:
- LOC606495
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2008-12-03
- Date modifiied:
- 2016-01-19
Related products to: LOC606495 Blocking Peptide
Related articles to: LOC606495 Blocking Peptide
- Extreme intestinal polyposis in pet dogs has not yet been reported in literature. We identified a dog patient who developed numerous intestinal polyps, with the severity resembling human classic familial adenomatous polyposis (FAP), except the jejunum-ileum junction being the most polyp-dense. We investigated this dog, in comparison with 22 other dogs with spontaneous intestinal tumors but no severe polyposis, and with numerous published human cancers. We found, not mutation, but three other alteration pathways as likely reasons of this canine extreme polyposis. First, somatic truncation mutation W411X of FBXW7, a component of an E3 ubiquitin ligase, over-activates MYC and cell cycle-promoting network, accelerating crypt cell proliferation. Second, genes of protein trafficking and localization are downregulated, likely associated with germline mutation G406D of STAMBPL1, a K63-deubiquitinase, and MYC network activation. This inhibits epithelial apical-basolateral polarity establishment, preventing crypt cell differentiation. Third, , a commensal gut anaerobe, thrives and expresses abundantly thioredoxin and nitroreductase. These bacterial products could reduce oxidative stress linked to host germline mutation R51X of CYB5RL, a cytochrome b5 reductase homologue, decreasing cell death. Our work emphasizes the close collaboration of alterations across the genome, transcriptome and microbiome in promoting tumorigenesis. - Source: PubMed
Publication date: 2018/06/26
Wang JinWang TianfangBishop Micah AEdwards John FYin HangDalton StephenBryan Laura KZhao Shaying