Ask about this productRelated genes to: TSHR Blocking Peptide
- Gene:
- TSHR NIH gene
- Name:
- thyroid stimulating hormone receptor
- Previous symbol:
- -
- Synonyms:
- LGR3
- Chromosome:
- 14q24-q31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-03-05
- Date modifiied:
- 2019-04-23
Related products to: TSHR Blocking Peptide
Related articles to: TSHR Blocking Peptide
- Graves' disease (GD) is a systemic autoimmune disorder, ultimately caused by autoantibodies stimulating the TSH receptor (TSHR-Ab) on thyroid follicular cells. Novel targeted therapies are under investigation, but treatment of GD still relies on antithyroid drugs (ATDs), radioactive iodine, or thyroidectomy. - Source: PubMed
Publication date: 2026/05/21
Bartalena LuigiGallo DanielaPiantanida ElianaTanda Maria Laura - Thyroid nodules are rare in children but carry a markedly higher risk of malignancy compared to adults (20%-26% vs. 5%). Hyperfunctioning thyroid nodules are exceptionally uncommon in the pediatric population and are typically benign. We describe a rare case of a hyperfunctioning thyroid nodule in a prepubertal child that was ultimately diagnosed as an angioinvasive encapsulated follicular carcinoma, arising in the context of the WHO entity 'follicular adenoma showing papillary architecture'. In addition, we provide a comprehensive review of published pediatric cases of hyperfunctioning thyroid nodules with malignant histology. - Source: PubMed
Publication date: 2026/05/15
Clausi CristinaCensi SimonaArnone Jacopo MariaMessina GiuliaPiva IlariaCortese FaustoBertazza LorisBarollo SusiGaluppini FrancescaZarantonello MarcoIacobone MaurizioPennelli GianmariaMian Caterina - Thyroid eye disease (TED) is an autoimmune disorder strongly associated with thyroid dysfunction. Its pathogenesis encompasses both hyperthyroidism and progressive pathological alterations in orbital tissues. - Source: PubMed
Publication date: 2026/05/14
Lv PanpanMa ZiyuLiu KunpengZheng WeiHao Rui - Transient congenital hypothyroidism (TCH) is characterized by congenital hypothyroidism (CH) which spontaneously resolves in the first years of life. While most cases are sporadic, several studies from worldwide showed variants in , genes in the etiology of TCH. The aim of our study is to evaluate the genetic etiology of TCH. - Source: PubMed
Publication date: 2026/05/12
Köprülü ÖzgeAcar SezerUzman Ceren YılmazErbaş İbrahim MertNalbantoğlu ÖzlemHazan FilizGürsoy SemraKorkmaz Hüseyin AnılÖzkan Behzat - Thyroid cancer (TC) is the most common endocrine malignancy, and challenges persist in preoperative diagnosis of indeterminate nodules and postoperative monitoring when thyroglobulin (Tg) assays are compromised by interfering anti-Tg antibodies (Tg-Ab). Extracellular vesicles (EVs) carry molecular cargo reflective of cells of origin and are increasingly explored as biomarker sources. In this study, we investigated whether thyroid-derived EVs retain the expression of thyroid-specific thyrotropin-receptor (TSHR), a suitable target in immunoaffinity-based EV isolation, and explored the presence of Tg in EV cargo as potential surrogate for serum Tg. EVs from thyroid cell lines (Nthy-Ori 3-1, TPC-1, OCUT2) and plasma of patients with benign, malignant tumors and recurrent TC were isolated by differential ultracentrifugation and characterized via nanoparticle tracking and Dot and Western blot analyses. EVs derived from Nthy-Ori 3-1 and TPC-1 cell lines were positive for surface TSHR and vesicular Tg, but not OCUT2. All plasma-derived EVs were positive for TSHR and Tg, while their electrophoretic profiles from vesicles differed compared to tissue lysate. Tg was detectable in EVs isolated from recurrent TC samples, even in Tg-Ab positive cases. Together, these results support the use of TSHR for targeted EV isolation and point to vesicular Tg as a potential recurrence marker. - Source: PubMed
Publication date: 2026/04/14
Bobar NevenaMitić NinoslavKosanović MajaŠelemetjev SonjaIšić Denčić TijanaTaušanović KatarinaJanković Miljuš Jelena