Ask about this productRelated genes to: IMPDH1 Blocking Peptide
- Gene:
- IMPDH1 NIH gene
- Name:
- inosine monophosphate dehydrogenase 1
- Previous symbol:
- RP10
- Synonyms:
- sWSS2608, LCA11
- Chromosome:
- 7q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-12-08
- Date modifiied:
- 2016-10-05
Related products to: IMPDH1 Blocking Peptide
Related articles to: IMPDH1 Blocking Peptide
- Osteosarcoma typically arises during adolescence, posing a significant challenge. Despite comprehensive treatment strategies encompassing surgery, radiation therapy, and chemotherapy, which can notably enhance long-term survival rates among osteosarcoma patients, the 5-year survival rate for metastatic cases remains discouragingly low. Consequently, early diagnosis and prompt intervention are paramount in improving the prognosis of patients afflicted with this condition. Metabolic reprogramming holds paramount significance in the initiation and progression of tumors. In this meticulous investigation, we devised a risk prediction model that encompasses seven pivotal nucleotide metabolism-related genes: MYC, MUC1, IMPDH1, SAMHD1, NUDT13, UCK2, and NUDT16. This model was formulated leveraging six advanced machine learning algorithms. The results demonstrated that the risk prediction model exhibited robust prognostic predictive capability. Notably, patients identified with a high-risk phenotype exhibited a significantly lower long-term survival rate, coupled with elevated expression of immunosuppressive genes, highlighting the importance of metabolic reprogramming in influencing both survival outcomes and immune status. The multivariate Cox regression analysis confirmed that our model serves as an independent prognostic indicator, significantly impacting the long-term prognosis of osteosarcoma patients. Subsequently, we developed and validated a nomogram, which accurately predicts 1-, 3-, and 5-year survival rates for these patients. Furthermore, we compared chemosensitivity between high- and low-risk groups, gaining valuable insights into potential therapeutic differences. In conclusion, this model demonstrates superior prognostic predictive capability and holds promise in guiding chemotherapy treatment strategies for osteosarcoma patients, thereby enhancing treatment outcomes. - Source: PubMed
Publication date: 2026/05/02
Ju SongliTao LuLi XuyanHuang NijiaoKe Xixian - Endometrial cancer is one of the most common gynecologic malignancies, with increasing evidence suggesting the involvement of immune-related processes rather than direct immune evasion mechanisms in its progression. However, effective immune-related biomarkers for prognostic evaluation and therapeutic targeting remain limited. This study aimed to identify novel immune-associated molecules based on clinical endometrial cancer specimens using integrated proteomic and bioinformatic approaches. Proteomic analysis was performed on tumor and adjacent normal tissues from endometrial cancer patients. Differentially expressed proteins were screened and further analyzed through transcriptomic validation, survival analysis, immune infiltration assessment, and pathway enrichment to explore their clinical relevance and potential functional roles in the tumor immune microenvironment. IMPDH1 was identified as a significantly upregulated protein in endometrial cancer and was associated with unfavorable prognosis. High expression of IMPDH1 was correlated with reduced CD8⁺ T cell infiltration and features of an immunosuppressive tumor microenvironment. Functional enrichment suggested its involvement in purine metabolism and a potential role in immune-related processes. This study identifies IMPDH1 as a novel immune-related biomarker in endometrial cancer, with potential value for prognosis and immunotherapy. - Source: PubMed
Publication date: 2026/04/30
Chen YongningMa FeiChen WeichangJiang RuibinWu FeiGong ShipengZhang Yadi - Grape seed proanthocyanidin extract (GSPE), derived from Vitis vinifera L., has been used in traditional European and Mediterranean medicine to treat inflammation, vascular diseases, and wounds. Historically employed for "detoxification" and "hard lumps" (possibly tumors), its effects are now attributed to GSPE's antioxidant and antiproliferative properties. Modern studies suggest these mechanisms may underlie its potential anticancer applications, including against bladder cancer. - Source: PubMed
Publication date: 2026/04/08
Han XiangDong ShuhongWang YingwenFang XingqiGu MengLi XiuyaWu YongjieZhang Baolai - How intestinal immunity develops during early life remains a key question in understanding defense against infections. Group 3 innate lymphoid cells (ILC3s) are critical for this defense, and their developmental progression and subset balance are essential for effective immune function. Here, we show that the nuclear receptor Nur77 helps control NKp46 ILC3 development in newborn mice. Mice lacking Nur77 have fewer ILC3s and failed to convert one ILC3 subtype (NKp46) into a more protective form (NKp46), reducing their ability to fight serovar Typhimurium infection. We found that 12R-hydroxyeicosatetraenoic acid (12R-HETE), a natural lipid found in the intestine, binds to Nur77 and boosts the expression of transcription factor T-box expressed in T cells (T-bet), promoting the shift to NKp46 ILC3s and increasing the production of interferon-γ (IFN-γ), a key immune molecule. This response is dependent on Nur77. Further analyses have revealed that Nur77 directly regulates a gene called , which supports this immune transition. Our findings uncover a Nur77-driven pathway that helps shape gut immunity in early life. - Source: PubMed
Publication date: 2026/02/20
Huang NingningYang ZhipengYou YaojieYe LingLi HaoPeng JianWei Hongkui - A hallmark of the IMPDH1-related rod-cone dystrophy is the highly variable expressivity. Disease onset, severity and progression are variant-dependent due to specific affected photoreceptor mechanisms, underscoring the importance of genotype-phenotype correlations. We provide a detailed clinical characterization of a patient with rod-cone dystrophy caused by a rare de novo missense IMPDH1 variant. - Source: PubMed
Publication date: 2026/02/15
Barboni MirellaJávorszky EszterQuinodoz MathieuHan Ji HoonResch MiklósNagy Zoltán ZsoltRivolta CarloTory KálmánSzabó Viktória