Ask about this productRelated genes to: NKIRAS2 Blocking Peptide
- Gene:
- NKIRAS2 NIH gene
- Name:
- NFKB inhibitor interacting Ras like 2
- Previous symbol:
- -
- Synonyms:
- KBRAS2, DKFZP434N1526, kappaB-Ras2
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-31
- Date modifiied:
- 2016-10-05
Related products to: NKIRAS2 Blocking Peptide
Related articles to: NKIRAS2 Blocking Peptide
- Epidemiological data link hyperlipidemia to increased depression susceptibility. This study investigates the potential involvement of 4-hydroxybenzyl alcohol (4-HBA), a bioactive molecule known for its neuroprotective and anti-inflammatory effects, in the pathophysiology of hyperlipidemia-associated depression. High-fat diet (HFD)-fed mice develop concurrent hyperlipidemia and depression-like behaviors, with 4-HBA identified as a key modulated brain metabolite in fecal microbiota transplantation recipients. In HFD-fed mice, 4-HBA treatment simultaneously improves lipid metabolism and significantly alleviates depression-like behaviors, accompanied by suppression of the nuclear factor κB (NF-κB) signaling pathway in the brain. In LPS-stimulated BV2 cells, 4-HBA inhibits NF-κB activation through NF-κB inhibitor interacting Ras-like 2 (NKIRAS2), thereby coordinating the downregulation of inflammatory responses. Conditioned medium from 4-HBA-treated BV2 cells enhances neuronal viability and reduces inflammatory responses in HT22 neurons in co-culture. Importantly, silencing Nkiras2 in BV2 cells and organotypic brain slice cultures negated the anti-inflammatory and neuroprotective actions of 4-HBA. These findings demonstrate that the NKIRAS2/NF-κB pathway is a molecular mediator underlying the biological effects of 4-HBA. These findings position 4-HBA as a dual-action metabolite capable of concurrently mitigating metabolic and psychiatric manifestations through neuroinflammatory regulation. - Source: PubMed
Publication date: 2026/03/09
Zhang YingTeng MengHe WenxuanLi LanzhouZhang YongfengWang ShimiaoWang ChunyueWang Di - Bacterial meningitis involves complex molecular networks, including microRNA-mediated regulation of inflammatory responses; however, the specific role of Ovis aries microRNA-125b (oar-miR-125b) in this process remains poorly understood. In this study, using a lamb model of Enterococcus faecalis-induced meningitis, we observed significant downregulation of oar-miR-125b, which inversely correlated with its newly identified target, Tumor Necrosis Factor Superfamily Member 4 (TNFSF4). Dual-luciferase reporter assays confirmed that oar-miR-125b directly binds to the 3' Untranslated Region (3'UTR) of TNFSF4 but not to the 3'UTRs of Kelch Like Family Member 31 (KLHL31) or NF-κB Inhibitor Interacting Ras Like 2 (NKIRAS2). Mechanistically, decreased oar-miR-125b expression relieves its repression of TNFSF4, leading to NF-κB pathway activation and blood-brain barrier disruption. Collectively, our results demonstrate that oar-miR-125b serves as a key anti-inflammatory regulator in bacterial meningitis by targeting TNFSF4 and constraining NF-κB signaling, highlighting its potential as a therapeutic target for attenuating neuroinflammation in meningitis. - Source: PubMed
Publication date: 2025/11/21
Jiao LonglingWu YouQi BoruiZhao PengfeiZhou MingZhang RunzeLi YongjianRen JingjingCao ShuzhuQi Yayin - Bladder cancer exhibits marked spatial heterogeneity in gene expression and immune infiltration. In this exploratory pilot study, we integrate multiplex fluorescence in situ hybridization (mFISH) with AI-assisted digital pathology to characterize the spatial distribution of a previously validated three-gene arsenic-responsive risk model (NKIRAS2, AKTIP, HLA-DQA1). Initially identified in arsenic-exposed individuals and associated with bladder cancer risk, this gene panel achieved 94% training and 75% validation AUC in prior genomic models (PMC8760535). We analyzed five bladder tumor specimens using whole-slide mFISH imaging and HoverNet-based nuclear segmentation to quantify gene expression at single-cell resolution. Spatial profiling revealed elevated expression scores in tumor-adjacent regions, with a strong positive correlation to tumor grade (Pearson's r = 0.83). These gene-enriched regions exhibited spatial clustering of tumor cells. Additionally, tumor-infiltrating lymphocyte (TIL) density was inversely correlated with tumor grade, suggesting immune exclusion in high-grade tumors. Our findings demonstrate the feasibility of combining spatial transcriptomics with AI-driven histopathological analysis for biomarker validation. This integrative framework provides a foundation for future population-scale studies leveraging spatial omics to evaluate arsenic-associated gene signatures and assess their relevance in bladder cancer risk stratification and disease progression. - Source: PubMed
Publication date: 2025/10/30
Singhal SonalikaSinghal SamarthGardner Kevin LDikshit AnushkaDoolittle EmeraldSens DonaldSens Mary AMiller Michael LAung Sai Tun HeinSinghal Sandeep K - Despite many new drugs, multiple myeloma (MM) remains an incurable plasma cell malignancy, and drug resistance is a long-standing topic in this field. Characterized by efficient transcription without being limited by the double helix structure and promoter, extrachromosomal circular DNA (EccDNA) has been proven to be widely involved in cancer development and drug resistance. - Source: PubMed
Publication date: 2025/07/18
Li FangfangLong XinyiTang SishiYan JinhuaLiu JingFu Yunfeng - The goal of this research was to examine the expression levels of Glucose-Fructose Oxidoreductase Domain Containing 1 (GFOD1) and to explore how it influences the proliferation, migration, and invasion of cancer cells in clear cell renal cell carcinoma (ccRCC, also known as KIRC). - Source: PubMed
Publication date: 2025/07/01
Liu ZhiWu KuiShu QianChen Xin