Ask about this productRelated genes to: RNF144B Blocking Peptide
- Gene:
- RNF144B NIH gene
- Name:
- ring finger protein 144B
- Previous symbol:
- IBRDC2
- Synonyms:
- bA528A10.3, P53RFP
- Chromosome:
- 6p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-06-25
- Date modifiied:
- 2018-11-19
Related products to: RNF144B Blocking Peptide
Related articles to: RNF144B Blocking Peptide
- - Source: PubMed
Publication date: 2026/04/15
Hu YuxinChen LuSha JianmeiShao CaihongGao JunliYao Jianhua - Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy with poor clinical outcomes, underscoring the urgent need for robust prognostic biomarkers and therapeutically tractable regulatory molecules. Long non-coding RNAs (lncRNAs) have emerged as key modulators of tumor progression and immune regulation; however, the prognostic and functional significance of TMPO-AS1 in LUAD remains largely unexplored. - Source: PubMed
Publication date: 2026/04/13
Nirmal SakshiSaini ChainseeBaweja BhavikaVats PrernaPatidar PrachiJangir KritikaNema Rajeev - Stroke, as a predominant cerebrovascular event, is characterized by disproportionately high morbidity, disability, and mortality rates. The central role of neuroinflammation in its pathophysiology underscores the clinical significance of modulating related regulatory pathways. Notably, ring finger protein 144B (RNF144B), an E3 ubiquitin ligase with demonstrated anti-inflammatory properties, presents a potential novel therapeutic target. Herein, we aimed to rigorously investigate RNF144B's involvement in stroke pathogenesis and delineate its mechanistic underpinnings. RNF144B knockout (KO) and wild-type (WT) C57BL/6 male mice were subjected to middle cerebral artery occlusion (MCAO) to mimic ischemic stroke. Co-immunoprecipitation, immunofluorescent staining, western blot, RT-PCR were used to investigate the function and mechanism of RNF144B during MCAO. RNF144B expression was significantly upregulated following cerebral ischemic stroke. The absence of RNF144B promotes microglial activation and polarization, exacerbating neuroinflammatory responses. Mechanistically, RNF144B interacts with and promotes the K48-linked ubiquitination of Tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3), leading to its proteasomal degradation. The absence of RNF144B stabilizes TRAF3, thereby enhancing the activation of NF-κB and MAPK signaling pathways. Importantly, TRAF3 knockdown in RNF144B-deficient mice partially reversed the detrimental effects on neurological function, microglial activity, and neuroinflammation post-MCAO. The absence of RNF144B exacerbates stroke-induced neuroinflammation through TRAF3 stabilization, revealing this E3 ubiquitin ligase as a potential therapeutic target for cerebral ischemia. - Source: PubMed
Publication date: 2026/03/27
Hu DianboZhao ShuhuiJin YuetingYang ChenHu YugangLiu QianMa Renzheng - Major depressive disorder (MDD) is a serious neuropsychiatric disorder. While emerging evidence suggests that PANoptosis may play a role in MDD pathogenesis, the precise involvement of PANoptosis-related genes remains unclear. - Source: PubMed
Publication date: 2025/10/02
Zhang HuanHuang NaMa XinxinLiu Yanan - RNF144 family proteins, including RNF144A and RNF144B, members of the RING-between-RING domain-containing ubiquitin E3 ligase family, serve as critical regulators of protein ubiquitination. Despite increasing research attention in recent years, particularly regarding their distinct functional roles in pathophysiological processes, a comprehensive synthesis of existing findings remains absent. To address this knowledge gap, we conducted a systematic literature search in PubMed using the following query terms: "RNF144," "RNF144A," "RNF144B," "PIR2," "IBRDC2," and "P53RFP." This review systematically examines current evidence regarding the molecular mechanisms and pathophysiological significance of RNF144A/B across various disease systems. Through critical analysis of structural characteristics, substrate interactions, and signaling pathways, we aim to clarify their dual roles in cellular homeostasis and disease pathogenesis. This synthesis not only consolidates current understanding but also identifies key knowledge gaps requiring further investigation, particularly regarding isoform-specific functions and therapeutic targeting potential. - Source: PubMed
Publication date: 2025/08/01
Jiang WangLiang YiHan MinHe WenhuaChen KunDeng ChongtianShen Yueming