Ask about this productRelated genes to: RGS20 Blocking Peptide
- Gene:
- RGS20 NIH gene
- Name:
- regulator of G protein signaling 20
- Previous symbol:
- -
- Synonyms:
- RGSZ1, ZGAP1
- Chromosome:
- 8q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-09
- Date modifiied:
- 2017-04-13
Related products to: RGS20 Blocking Peptide
Related articles to: RGS20 Blocking Peptide
- Clear cell renal cell carcinoma (ccRCC) is an angiogenic tumor originating from proximal tubule epithelial cells. Ammonia induced cell death is closely associated with carcinogenesis, but its potential mechanism in ccRCC remains unclear and requires further investigation. - Source: PubMed
Publication date: 2026/04/23
Jiang YaoZhang TianFan JieSu YanshengQiao ShaoyiJi JintaoHu XiangnanZhou ShuchangWei YingjuanDu LinaYang BoZhang Wuhe - The poor prognosis of lung adenocarcinoma (LUAD) remains unimproved. This study aimed to identify lymph node metastasis (LNM)-related and cellular immunity-related prognostic genes in LUAD and propose novel strategies to improve its prognosis. LUAD-related datasets were obtained from public databases. Prognostic genes and a prognostic model were obtained through various bioinformatics analyzes, and the immunotherapy response in risk groups was assessed. Subsequently, the expression levels of prognostic genes and the intercellular communication relationships were explored at the single-cell level. Moreover, malignant cells were identified, and their differentiation mechanisms were explored via inferCNV analysis. Additionally, FURIN was silenced and overexpressed to investigate its effects on the invasion, metastasis, and lymphangiogenesis of LUAD cells in vitro. RGS20, KYNU, RAET1E, FGF12, GJB2, CACNA2D2, FURIN, and GDF10 were identified as prognostic genes with LNM. In 4 datasets, LUAD patients with the high LNM and immune cell-related risk scores exhibited higher mortality rates compared to those in the low-risk group. Furthermore, individuals in the low-risk group demonstrated a greater propensity to derive advantages from immunotherapeutic interventions. Epithelial cells were identified as key cells, with CACNA2D2 being significantly up-regulated during their late-stage differentiation. Basal cells, the malignant subset within epithelial cells, showed elevated FURIN expression in the pre-differentiation phase, which declined in the middle and late phases. Functionally, FURIN was found to enhance the migratory and proliferative capacities of LUAD cells. Moreover, we demonstrated that FURIN accelerated lymphatic metastasis and lymphangiogenesis in vitro. In this paper, we identified LUAD prognostic genes with LNM and immune cell signatures, emphasized treating LUAD patients according to LNM- and immune cell-related risk scores, and provided novel ideas on how to improve poor prognosis and develop targeted therapy for LUAD. - Source: PubMed
Lin ChuanChen XuanSun YongTang XiaomeiJiang Yi - Lung adenocarcinoma (LUAD) represents an aggressive malignancy characterized by high metastatic potential. Emerging evidence suggests mitochondrial DNA methylation (MTDM) plays a pivotal role in regulating gene expression through protein synthesis modulation, yet its mechanistic involvement in LUAD pathogenesis remains poorly understood. - Source: PubMed
Publication date: 2026/02/10
Ding JianCheng GangXue QianGuo WeizhenCheng YikunYang ChengTong JiabingLi ZegengGao Yating - Lung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality worldwide. Although established biomarkers guide targeted therapy, their utility in prognostic stratification remains limited. In this study, we. - Source: PubMed
Publication date: 2026/01/31
Zheng QingzhuWeng JiamiaoZhu BinLi MingjieZhu XianjinCao Yingping - - Source: PubMed
Publication date: 2025/12/16
Yang LinLi ShuoZhou QiaoLiu Wei