Ask about this productRelated genes to: ZNF682 Blocking Peptide
- Gene:
- ZNF682 NIH gene
- Name:
- zinc finger protein 682
- Previous symbol:
- -
- Synonyms:
- BC39498_3
- Chromosome:
- 19p12
- Locus Type:
- gene with protein product
- Date approved:
- 2005-03-31
- Date modifiied:
- 2014-11-19
Related products to: ZNF682 Blocking Peptide
Related articles to: ZNF682 Blocking Peptide
- The anadromous Atlantic salmon undergo a preparatory physiological transformation before seawater entry, referred to as smoltification. Key molecular developmental processes involved in this life stage transition, such as remodeling of gill functions, are known to be synchronized and modulated by environmental cues like photoperiod. However, little is known about the photoperiod influence and genome regulatory processes driving other canonical aspects of smoltification such as the large-scale changes in lipid metabolism and energy homeostasis in the developing smolt liver. Here we generate transcriptome, DNA methylation, and chromatin accessibility data from salmon livers across smoltification under different photoperiod regimes. We find a systematic reduction of expression levels of genes with a metabolic function, such as lipid metabolism, and increased expression of energy related genes such as oxidative phosphorylation, during smolt development in freshwater. However, in contrast to similar studies of the gill, smolt liver gene expression prior to seawater transfer was not impacted by photoperiodic history. Integrated analyses of gene expression, chromatin accessibility, and transcription factor (TF) binding signatures highlight chromatin remodeling and TF dynamics underlying smolt gene regulatory changes. Differential peak accessibility patterns largely matched differential gene expression patterns during smoltification and we infer that ZNF682, KLFs, and NFY TFs are important in driving a liver metabolic shift from synthesis to break down of organic compounds in freshwater. Overall, chromatin accessibility and TFBS occupancy were highly correlated to changes in gene expression. On the other hand, we identified numerous differential methylation patterns across the genome, but associated genes were not functionally enriched or correlated to observed gene expression changes across smolt development. Taken together, this work highlights the relative importance of chromatin remodeling during smoltification and demonstrates that metabolic remodeling occurs as a preadaptation to life at sea that is not to a large extent driven by photoperiod history. - Source: PubMed
Publication date: 2024/04/22
Harvey Thomas NGillard Gareth BRøsæg Line LGrammes FabianMonsen ØysteinVik Jon OlavHvidsten Torgeir RSandve Simen R - Endoscopic Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) detection is invasive and expensive. Nonendoscopic BE/EAC detection tools are guideline-endorsed alternatives. We previously described a 5-methylated DNA marker (MDM) panel assayed on encapsulated sponge cell collection device (CCD) specimens. We aimed to train a new algorithm using a 3-MDM panel and test its performance in an independent cohort. - Source: PubMed
Publication date: 2024/03/19
Iyer Prasad GSlettedahl Seth WMahoney Douglas WGiakoumopoulos MariaOlson Marilyn CKrockenberger MartinTaylor William RFoote PatrickBerger CaliseLeggett CadmanWu Tsung-TehAntpack EduardoFalk Gary WGinsberg Gregory GAbrams Julian ALightdale Charles JRamirez FranciscoKahn AllonWolfsen HerbertKonda VaniTrindade Arvind JKisiel John B - Lung adenocarcinoma (LUAD) is a common cancer with a poor prognosis. Pyroptosis is an important process in the development and progression of LUAD. We analyzed the risk factors affecting the prognosis of patients and constructed a nomogram to predict the overall survival of patients based on different pyroptosis-related genes (PRGs) subtypes. - Source: PubMed
Publication date: 2023/12/18
Wen ZiangPei BeiDai LongfeiLu PengLi XiangyuZhang ChengxinGe Shenglin - Minimally invasive methods have been described to detect Barrett's esophagus (BE), but are limited by subjectivity and suboptimal accuracy. We identified methylated DNA markers (MDMs) for BE in tissue and assessed their accuracy on whole esophagus brushings and capsule sponge samples. - Source: PubMed
Publication date: 2018/06/12
Iyer Prasad GTaylor William RJohnson Michele LLansing Ramona LMaixner Kristyn AYab Tracy CSimonson Julie ADevens Mary ESlettedahl Seth WMahoney Douglas WBerger Calise KFoote Patrick HSmyrk Thomas CWang Kenneth KWolfsen Herbert CAhlquist David A