ACDC Blocking Peptide
- Known as:
- ACDC Blocking Peptide
- Catalog number:
- 33r-4384
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- ACDC Blocking Peptide
Related genes to: ACDC Blocking Peptide
- Gene:
- ADIPOQ NIH gene
- Name:
- adiponectin, C1Q and collagen domain containing
- Previous symbol:
- ACDC
- Synonyms:
- ACRP30, AdipoQ, apM1, GBP28, adiponectin
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-26
- Date modifiied:
- 2016-10-05
- Gene:
- ADIPOR1 NIH gene
- Name:
- adiponectin receptor 1
- Previous symbol:
- -
- Synonyms:
- PAQR1, ACDCR1
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-23
- Date modifiied:
- 2018-05-03
- Gene:
- ADIPOR2 NIH gene
- Name:
- adiponectin receptor 2
- Previous symbol:
- -
- Synonyms:
- PAQR2, ACDCR2
- Chromosome:
- 12p13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-23
- Date modifiied:
- 2018-05-03
Related products to: ACDC Blocking Peptide
Related articles to: ACDC Blocking Peptide
- : Most genes involved in the pathogenesis of Metabolic Syndrome (MS) and Type 2 Diabetes Mellitus (T2DM) are regulated by peroxisome proliferator-activated receptors (PPARs), which modulate the production of pro-inflammatory cytokines, with interleukin-6 (IL-6) playing a crucial role. The associations of single-nucleotide polymorphisms (SNPs) with MS and T2DM remain uncertain across populations. Therefore, we aimed to investigate the associations of PPAR-related SNPs in , , , , and with MS and T2DM clinical features. : Polymorphism analysis of , , , , and genes was performed on isolated DNA from individuals diagnosed with T2DM and from healthy controls using real-time polymerase chain reaction (qPCR). : The polymorphism shows that the CC genotype is associated with higher MS risk, whereas the GG genotype appears protective against metabolic disturbances. When the CC genotype is combined with GA or 219 A/T, hyperglycemia is 1.3 times more frequent than with other genotype combinations. : To develop informative genetic risk scores, future studies should include additional polymorphisms in key immune-metabolic pathway genes, such as , , and - Source: PubMed
Publication date: 2025/09/20
Shramko IulianaAgeeva ElizavetaKubishkin AnatoliiMakalish TatyanaTarimov CyrillBondar' Dmitry - Monocyte-derived macrophages (MDMs) are key innate immune cells involved in all stages of atherosclerosis. Adiponectin is an anti-inflammatory hormone that modulates macrophage functions by interacting with adiponectin receptor (AdipoR)1 and AdipoR2. However, sex-specific AdipoR patterns in macrophages among people at risk for atherosclerosis have not been investigated. We evaluated the effects of adiponectin in MDMs on AdipoR1/R2 gene expression and inflammatory responses between males and females with cardiovascular (CV) risk factors and without atherosclerosis. - Source: PubMed
Publication date: 2025/05/06
Gianopoulos IoannaDaskalopoulou Stella S - Although innate immunity is critical for antifungal host defense against the human opportunistic fungal pathogen Aspergillus fumigatus, potentially damaging inflammation must be controlled. Adiponectin (APN) is an adipokine produced mainly in adipose tissue that exerts anti-inflammatory effects in adipose-distal tissues such as the lung. We observed increased mortality and increased fungal burden and inflammation in neutropenic mice with invasive aspergillosis (IA) that lack APN or the APN receptors AdipoR1 or AdipoR2. Alveolar macrophages (AMs), early immune sentinels that detect and respond to lung infection, express both receptors, and APN-deficient AMs exhibited an inflammatory phenotype that was associated with decreased fungal killing. Pharmacological stimulation of AMs with AdipoR agonist AdipoRon rescued deficient killing in APN-/- AMs and was dependent on the presence of either receptor. Finally, APN-enhanced fungal killing was associated with increased activation of the non-canonical LC3 pathway of autophagy. Thus, our study identifies a novel role for APN in LC3-mediated killing of A.fumigatus. - Source: PubMed
Publication date: 2025/03/17
Goli Sri HarshiniLim Joo-YeonBasaran-Akgul NeseTempleton Steven P - Adiponectin (ADIPOQ) gene is considered to be one of the promising players in deciphering the genetic bases of type 2 diabetes. This study investigated the associations between haplotype combinations of three single nucleotide polymorphisms (SNPs) of the ADIPOQ gene and two SNPs of the adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2) genes with environmental risk factors for the prediction of T2DM disorder susceptibility in the Iranian population. - Source: PubMed
Publication date: 2024/08/14
Mamashli ElaheGoulding Richie PIranparvar ManouchehrSkishahr Farnaz SeifiSiahkouhian MarefatRamezanzade RaziyeJaspers Richard TDavarnia Behzad - Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common monogenic disorder characterized by renal cysts and progressive renal failure. In kidney diseases, adipose tissue undergoes functional changes that have been associated with increased inflammation and insulin resistance mediated by release of adipokines. Adiponectin is involved in various cellular processes, such as energy and inflammatory and oxidative processes. However, it remains to be determined whether adiponectin is involved in the concomitant metabolic dysfunctions present in PKD. In this scenario, we aimed to analyze: (a) PPARγ, ADIPOQ, ADIPOR1 and ADIPOR2 gene variations in 92 ADPKD patients through PCR-Sanger sequencing; and (b) adiponectin levels and its oligomerization state by ELISA and Western Blot. Our results indicated that: (a) 14 patients carried the PPARγ SNP, 29 patients carried the ADIPOQ SNP rs1501299, and 25 patients carried the analyzed ADIPOR1 SNPs. Finally, 82 patients carried ADIPOR2 SNPs; and (b) Adiponectin is statistically lower in ADPKD patients compared to controls, and further statistically lower in ESRD than in non-ESRD patients. An inverse relationship between adiponectin and albumin and between adiponectin and creatinine and a direct relationship between adiponectin and eGFR were found. Interestingly, significantly lower levels of adiponectin were found in patients bearing the ADIPOQ rs1501299 SNP and associated with low levels of eGFR. In conclusion, adiponectin levels and the presence of ADIPOQ rs1501299 genotype are significantly associated with a worse ADPKD phenotype, indicating that both could potentially provide important insights into the disease. Further studies are warranted to understand the pathophysiological role of adiponectin in ADPKD patients. - Source: PubMed
Publication date: 2024/04/11
Nigro ErsiliaMallardo MartaAmicone MariaD'Arco DanielaRiccio EleonoraMarra MaurizioPasanisi FabrizioPisani AntonioDaniele Aurora