Ask about this productRelated genes to: ZNF710 Blocking Peptide
- Gene:
- ZNF710 NIH gene
- Name:
- zinc finger protein 710
- Previous symbol:
- -
- Synonyms:
- DKFZp547K1113, FLJ37393, FLJ00306
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-10-30
- Date modifiied:
- 2014-11-19
Related products to: ZNF710 Blocking Peptide
Related articles to: ZNF710 Blocking Peptide
- This study aimed to investigate the mechanism underlying the role of Zinc finger protein 710 (ZNF710) in gastric cancer (GC). - Source: PubMed
Publication date: 2025/12/25
Zhou RunkaiZhou JingyiCai JinfengWen JiazheWang FazhiMa DiLuo QingshanYalikun AbudushalamuHan JinluZhou XuefengYu YangLi QiWen Yugang - Investigations have shown that understanding the regulatory mechanisms of the osteogenic differentiation of periodontal ligament stem cells (PDLSCs) can significantly enhance the regenerative capacity of periodontal tissues and mitigate periodontal disorders. Improving osteogenesis in dental implants is complex, requiring better bone regeneration and integration with the implant surface. ZNF710-AS1 is identified as a key regulator of osteogenic differentiation via the BMP6/Smad pathway, with the overexpression of miR-146a-5p and miR-146b-5p inhibiting ZNF710-AS1's osteogenic effects. This study explores the role of the long noncoding RNA ZNF710-AS1 in PDLSC osteogenic differentiation and clarifies its molecular mechanisms. Results indicate that ZNF710-AS1 expression positively influences osteogenic differentiation, while miR-146a-5p has a suppressive effect. ZNF710-AS1 serves as a competing endogenous RNA (ceRNA) for miR-146a-5p, increasing BMP6 levels and activating the Smad signaling pathway. The study also highlights the role of miR-146a-5p in osteogenesis and inflammation in peri-implant tissues. Findings suggest miR-146a-5p promotes osteogenic differentiation and could be a potential biomarker for periodontal conditions. In summary, this research provided key insights into the molecular mechanisms of osteogenesis and advocates for targeting ZNF710-AS1 and miR-146a-5p to improve dental implant integration and regenerative strategies for periodontal tissues. - Source: PubMed
Publication date: 2025/10/01
Mahmoudi Anzabi RezaShenasa NaghmehJafarian AliDavodpour Amir HosseinZareanshahraki MehranGhasemirad MohammadRostamzadeh Sajjad - Gastric cancer (GC) is a prevalent malignant tumor of the gastrointestinal system. ZNF710 is a transcription factor (TF), and zinc finger protein 710 (ZNF710)-AS1-201 is an immune-related long noncoding RNA (lncRNA) that is upregulated in GC cells. - Source: PubMed
Ding WeiChen Wei-WeiWang Yi-QinXu Xue-ZhongWang Yi-BoYan Yong-MinTan Yu-Lin - The interplay between melatonin and immune system is well recognized in humans. The true integration of research on cashmere goat is still far from clear, especially for cashmere goat maintained in wool and cashmere growth. In this study, we applied various approaches to identify the complex regulated network between the immune-related genes and transcription factors (TFs) and to explore the relationship between melatonin and gene expression in cashmere goats. In total, 1,599 and 1756 immune-related genes were found in the blood and skin of cashmere goats, respectively, and 24 differentially expressed immune-related GO terms were highly expressed in blood after melatonin implantation. We studied the melatonin-dependent networks between the TFs and immune-related genes in cashmere goat. The 3 major regulatory networks were interconnected through TFs. The TFs, such as and , were also expressed in the blood and skin tissue of cashmere goat. In addition, most genes in these networks, such as and , were involved in WNT pathway, which is related to cashmere wool growth regulation On the network basis, we developed a knockout mouse model to identify the network interaction. We observed that 8 high-sulfur protein genes, 12 keratin (KRT) genes, and 19 keratin associated protein (KRTAP) genes related to the growth of cashmere wool were almost not expressed in rat skin. Our results suggested that the expression of genes related to wool and cashmere growth may be regulated by the interaction network between genes affected by melatonin and immune-related genes. In summary, we outlined some particularly promising ways for future research on immune-related genes of cashmere goats and the role of melatonin in wool and cashmere growth. - Source: PubMed
Publication date: 2022/10/24
Chai YuanLiu ZaixiaFu ShaoyinLiu BinGuo LiliDai LingliSun YanyongZhang WenguangLi ChunLiu Taodi - Antisense long non-coding RNAs (AS lncRNAs) have been increasingly recognized as important regulators of gene expression and have been found to play crucial roles in the development and progression of tumors. The present study explored the roles of AS lncRNA ZNF710‑AS1‑202 in clear cell renal cell carcinoma (ccRCC). The expression levels of ZNF710‑AS1‑202 were detected in 46 human ccRCC tissues and 34 healthy adjacent renal tissues. The associations between the levels of ZNF710‑AS1‑202 expression and the clinicopathological features of the patients were evaluated by the χ2 test. Gain‑ and loss‑of‑function experiments were performed to analyze the role of ZNF710‑AS1‑202 in ccRCC cell proliferation and survival in vitro. Reverse transcription‑quantitative PCR and/or western blotting were employed to detect ZNF710‑AS1‑202, zinc finger protein 710 (ZNF710) and cyclin B1 expression. The Cell Counting Kit‑8 and colony formation assays, as well as flow cytometry, were used to detect cell proliferation or apoptosis. The subcellular localization of ZNF710‑AS1‑202 was analyzed by RNA fluorescence in situ hybridization. The results revealed that ZNF710‑AS1‑202 was downregulated in human ccRCC tissues and was associated with the pathological grade, tumor size, local invasion and TNM stage, but not with lymph node metastasis or distant metastasis. However, ZNF710‑AS1‑202 overexpression promoted the proliferation of RCC cells and inhibited apoptosis. Opposite results were observed when ZNF710‑AS1‑202 was knocked down by small interfering RNA. Furthermore, ZNF710‑AS1‑202, which was mainly expressed in the cytoplasm of RCC cells, regulated ZNF710 mRNA and protein expression in opposing manners. In conclusion, the present study revealed that ZNF710‑AS1‑202 and ZNF710 may serve as promising therapeutic targets for ccRCC. - Source: PubMed
Publication date: 2020/03/20
Li GangXie MenghanHuang ZhenlinLi HaoLi PengZhang ZhengguoDing YinghuiJia ZhankuiYang Jinjian